Search Results - "Sini, Patrizia"

Simultaneous inhibition of mTORC1 and mTORC2 by mTOR kinase inhibitor AZD8055 induces autophagy and cell death in cancer cells by Sini, Patrizia, James, Dominic, Chresta, Christine, Guichard, Sylvie

“…mTOR is a major biological switch, coordinating an adequate response to changes in energy uptake (amino acids, glucose), growth signals (hormones, growth…”
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The Novel ATP-Competitive MEK/Aurora Kinase Inhibitor BI-847325 Overcomes Acquired BRAF Inhibitor Resistance through Suppression of Mcl-1 and MEK Expression by Phadke, Manali S, Sini, Patrizia, Smalley, Keiran S M

“…Resistance to BRAF inhibitors is a major clinical problem. Here, we evaluate BI-847325, an ATP-competitive inhibitor of MEK and Aurora kinases, in…”
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mTOR Inhibitor RAD001 (Everolimus) Has Antiangiogenic/Vascular Properties Distinct from a VEGFR Tyrosine Kinase Inhibitor by Lane, Heidi A, Wood, Jeanette M, McSheehy, Paul M J, Allegrini, Peter R, Boulay, Anne, Brueggen, Joseph, Littlewood-Evans, Amanda, Maira, Sauveur-Michel, Martiny-Baron, Georg, Schnell, Christian R, Sini, Patrizia, O'Reilly, Terence

“…Purpose: Comparison of the antiangiogenic/vascular properties of the oral mammalian target of rapamycin (mTOR) inhibitor RAD001 (everolimus) and the vascular…”
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Wnt3a regulates proliferation and migration of HUVEC via canonical and non-canonical Wnt signaling pathways by Samarzija, Ivana, Sini, Patrizia, Schlange, Thomas, MacDonald, Gwen, Hynes, Nancy E.

“…Untangling the signaling pathways involved in endothelial cell biology is of central interest for the development of antiangiogenesis based therapies. Here we…”
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Inhibition of p53-MDM2 binding reduces senescent cell abundance and improves the adaptive responses of skeletal muscle from aged mice by Nolt, Georgia L., Keeble, Alexander R., Wen, Yuan, Strong, Aubrey C., Thomas, Nicholas T., Valentino, Taylor R., Brightwell, Camille R., Murach, Kevin A., Patrizia, Sini, Weinstabl, Harald, Gollner, Andreas, McCarthy, John J., Fry, Christopher S., Franti, Michael, Filareto, Antonio, Peterson, Charlotte A., Dungan, Cory M.

“…Skeletal muscle adaptation to external stimuli, such as regeneration following injury and hypertrophy in response to resistance exercise, are blunted with…”
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Preclinical evaluation of M30 and M65 ELISAs as biomarkers of drug induced tumor cell death and antitumor activity by Cummings, Jeffrey, Hodgkinson, Cassandra, Odedra, Rajesh, Sini, Patrizia, Heaton, Simon P, Mundt, Kirsten E, Ward, Tim H, Wilkinson, Robert W, Growcott, Jim, Hughes, Andrew, Dive, Caroline

“…M30 and M65 are ELISAs that detect different circulating forms of cytokeratin 18. Using the aurora kinase inhibitor AZD1152 and the SW620 human colon cancer…”
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The Antitumor and Antiangiogenic Activity of Vascular Endothelial Growth Factor Receptor Inhibition Is Potentiated by ErbB1 Blockade by SINI, Patrizia, WYDER, Lorenza, SCHNELL, Christian, O'REILLY, Terence, LITTLEWOOD, Amanda, BRANDT, Ralph, HYNES, Nancy E, WOOD, Jeanette

“…Purpose: Receptor tyrosine kinases of the ErbB family play important roles in the control of tumor growth. Vascular endothelial growth factor (VEGF) stimulates…”
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AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity by CHRESTA, Christine M, DAVIES, Barry R, JAMES, Dominic, HOWARD, Zoe, DUDLEY, Phillippa, HUGHES, Gareth, SMITH, Lisa, MAGUIRE, Sharon, HUMMERSONE, Marc, MALAGU, Karine, MENEAR, Keith, JENKINS, Richard, HICKSON, Ian, JACOBSEN, Matt, SMITH, Graeme C. M, GUICHARD, Sylvie, PASS, Martin, HARDING, Tom, COSULICH, Sabina, CRITCHLOW, Susan E, VINCENT, John P, ELLSTON, Rebecca, JONES, Darren, SINI, Patrizia

“…The mammalian target of rapamycin (mTOR) kinase forms two multiprotein complexes, mTORC1 and mTORC2, which regulate cell growth, cell survival, and autophagy…”
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Abstract 703: A novel ATP-competitive MEK/Aurora kinase inhibitor BI-847325 reverses acquired BRAF inhibitor resistance through suppression of Mcl-1 and inhibition of MEK expression by Phadke, Manali S., Sini, Patrizia, Smalley, Keiran

“…Abstract BACKGROUND: BRAF/MEK inhibitors have shown promising levels of response in melanomas harboring the BRAF V600E mutation, however responses tend to be…”
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Heterogeneous Profile of ROR1 Protein Expression across Tumor Types by Raso, Maria Gabriela, Barrientos Toro, Elizve, Evans, Kurt, Rizvi, Yasmeen, Lazcano, Rossana, Akcakanat, Argun, Sini, Patrizia, Trapani, Francesca, Madlener, Eva Johanna, Waldmeier, Lorenz, Lazar, Alexander, Meric-Bernstam, Funda

“…The Wnt receptor ROR1 has generated increased interest as a cancer therapeutic target. Research on several therapeutic approaches involving this receptor is…”
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Pharmacological Profile of BI 847325, an Orally Bioavailable, ATP-Competitive Inhibitor of MEK and Aurora Kinases by Sini, Patrizia, Gürtler, Ulrich, Zahn, Stephan K, Baumann, Christoph, Rudolph, Dorothea, Baumgartinger, Rosa, Strauss, Eva, Haslinger, Christian, Tontsch-Grunt, Ulrike, Waizenegger, Irene C, Solca, Flavio, Bader, Gerd, Zoephel, Andreas, Treu, Matthias, Reiser, Ulrich, Garin-Chesa, Pilar, Boehmelt, Guido, Kraut, Norbert, Quant, Jens, Adolf, Günther R

“…Although the MAPK pathway is frequently deregulated in cancer, inhibitors targeting RAF or MEK have so far shown clinical activity only in BRAF- and…”
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Abstract LB003: BI 907828: A highly potent MDM2-p53 antagonist suitable for intermittent dose schedules by Gollner, Andreas, Sini, Patrizia, Rudolph, Dorothea, Weinstabl, Harald, Ramharter, Juergen, Weyer-Czernilofsky, Ulrike, Golubovic, Bojana, Grempler, Rolf, Pitarch, Alejandro Pérez, Sailer, Reinhard, McConnell, Darryl B., Kraut, Norbert

“…Abstract The E3 ligase MDM2 controls the tumor suppressor function of p53, which is encoded by the TP53gene. Compounds designed to bind to MDM2 preventing its…”
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Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation by Di Fiore, Pier Paolo, Scita, Giorgio, Sini, Patrizia, Cannas, Angela, Koleske, Anthony J

“…The non-receptor tyrosine kinase Abl participates in receptor tyrosine kinase (RTK)-induced actin cytoskeleton remodelling, a signalling pathway in which the…”
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Inhibition of Multiple Vascular Endothelial Growth Factor Receptors (VEGFR) Blocks Lymph Node Metastases but Inhibition of VEGFR-2 Is Sufficient to Sensitize Tumor Cells to Platinum-Based Chemotherapeutics by SINI, Patrizia, SAMARZIJA, Ivana, SETYONO-HAN, Buddy, WOOD, Jeanette, HYNES, Nancy E, BAFFERT, Fabienne, LITTLEWOOD-EVANS, Amanda, SCHNELL, Christian, THEUER, Andreas, CHRISTIAN, Sven, BOOS, Anja, HESS-STUMPP, Holger, FOEKENS, John A

“…Vascular endothelial growth factor receptors (VEGFR) have important roles in cancer, affecting blood and lymphatic vessel functionality as well as tumor cells…”
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Abstract 1919: Pharmacological characterization of BI 847325, a dual inhibitor of MEK and Aurora kinases by Sini, Patrizia, Gürtler, Ulrich, Zahn, Stephan K., Boehmelt, Guido, Garin-Chesa, Pilar, Kraut, Nobert, Rudolph, Dorothea, Solca, Flavio, Tontsch-Grunt, Ulrike, Waizenegger, Irene C., Adolf, Günther R.

“…Abstract The RAS-dependent MAP kinase signaling pathway plays an important role in the regulation of cell proliferation and survival. RAS genes are frequently…”
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Inhibition of Aurora-B kinase activity confers antitumor efficacy in preclinical mouse models of early and advanced gastrointestinal neoplasia by ALFEREZ, DENIS G, GOODLAD, ROBERT A, ODEDRA, RAJESH, SINI, PATRIZIA, CRAFTER, CLAIRE, RYAN, ANDERSON J, WEDGE, STEPHEN R, WRIGHT, NICHOLAS A, ANDERSON, ELIZABETH, WILKINSON, ROBERT W

“…The Aurora family of kinases, play a fundamental role in cell division and are overexpressed in several cancers including colon. The activity of…”
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An Effector Region in Eps8 Is Responsible for the Activation of the Rac-Specific GEF Activity of Sos-1 and for the Proper Localization of the Rac-Based Actin-Polymerizing Machine by Scita, Giorgio, Tenca, Pierluigi, Areces, Liliana B., Tocchetti, Arianna, Frittoli, Emanuela, Giardina, Giuseppina, Ponzanelli, Isabella, Sini, Patrizia, Innocenti, Metello, Di Fiore, Pier Paolo

“…Genetic and biochemical evidence demonstrated that Eps8 is involved in the routing of signals from Ras to Rac. This is achieved through the formation of a…”
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Role of decorin on in vitro fibrillogenesis of type I collagen by Sini, P, Denti, A, Tira, M E, Balduini, C

“…Tendon and corneal decorins are differently iduronated dermatan sulphate/proteoglycan (DS/PG) and the biochemical parameter that differentiates type I…”
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Interaction of decorin with CNBr peptides from collagens I and II. Evidence for multiple binding sites and essential lysyl residues in collagen by Tenni, Ruggero, Viola, Manuela, Welser, Franz, Sini, Patrizia, Giudici, Camilla, Rossi, Antonio, Tira, M Enrica

“…Decorin is a small leucine-rich chondroitin/dermatan sulfate proteoglycan reported to interact with fibrillar collagens through its protein core and to…”
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Interaction of decorin with CNBr peptides from collagens I and II by Tenni, Ruggero, Viola, Manuela, Welser, Franz, Sini, Patrizia, Giudici, Camilla, Rossi, Antonio, Tira, M. Enrica

“…Decorin is a small leucine‐rich chondroitin/dermatan sulfate proteoglycan reported to interact with fibrillar collagens through its protein core and to…”
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