Search Results - "Sinha, Vikash"

A Case of Unilateral Sixth Cranial Nerve (CN VI) Avulsion in the Prepontine Cistern After Severe Head Trauma by Kent, Thomas, Sinha, Vikash, Albayram, Mehmet

“…The patient was a 46-year-old woman who presented with right sixth cranial nerve (CN VI) palsy following severe head trauma secondary to a motor vehicle…”
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Mechanistic Understanding of Brain Drug Disposition to Optimize the Selection of Potential Neurotherapeutics in Drug Discovery by Loryan, Irena, Sinha, Vikash, Mackie, Claire, Van Peer, Achiel, Drinkenburg, Wilhelmus, Vermeulen, An, Morrison, Denise, Monshouwer, Mario, Heald, Donald, Hammarlund-Udenaes, Margareta

“…ABSTRACT Purpose The current project was undertaken with the aim to propose and test an in-depth integrative analysis of neuropharmacokinetic (neuroPK)…”
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PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 3: comparative assessement of prediction methods of human clearance by Ring, Barbara J, Chien, Jenny Y, Adkison, Kimberly K, Jones, Hannah M, Rowland, Malcolm, Jones, Rhys Do, Yates, James W T, Ku, M Sherry, Gibson, Christopher R, He, Handan, Vuppugalla, Ragini, Marathe, Punit, Fischer, Volker, Dutta, Sandeep, Sinha, Vikash K, Björnsson, Thorir, Lavé, Thierry, Poulin, Patrick

“…The objective of this study was to evaluate the performance of various allometric and in vitro-in vivo extrapolation (IVIVE) methodologies with and without…”
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Robust Adaptive Fault Estimation Observer-Based FTC Design for Time-Delay PEMFC Systems by Sinha, Vikash, Mondal, Sharifuddin

“…This work develops fault tolerant control (FTC) design based on robust adaptive fault estimation observer (RAFEO) for proton exchange membrane fuel cell…”
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PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: prediction of plasma concentration-time profiles in human by using the physiologically-based pharmacokinetic modeling approach by Poulin, Patrick, Jones, Rhys D O, Jones, Hannah M, Gibson, Christopher R, Rowland, Malcolm, Chien, Jenny Y, Ring, Barbara J, Adkison, Kimberly K, Ku, M Sherry, He, Handan, Vuppugalla, Ragini, Marathe, Punit, Fischer, Volker, Dutta, Sandeep, Sinha, Vikash K, Björnsson, Thorir, Lavé, Thierry, Yates, James W T

“…The objective of this study is to assess the effectiveness of physiologically based pharmacokinetic (PBPK) models for simulating human plasma…”
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Prediction of Human Pharmacokinetics Using Physiologically Based Modeling: A Retrospective Analysis of 26 Clinically Tested Drugs by DE BUCK, Stefan S, SINHA, Vikash K, FENU, Luca A, NIJSEN, Marjoleen J, MACKIE, Claire E, GILISSEN, Ron A. H. J

“…The aim of this study was to evaluate different physiologically based modeling strategies for the prediction of human pharmacokinetics. Plasma profiles after…”
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Urinary Tubular Protein-Based Biomarkers in the Rodent Model of Cisplatin Nephrotoxicity: A Comparative Analysis of Serum Creatinine, Renal Histology, and Urinary KIM-1, NGAL, and NAG in the Initiation, Maintenance, and Recovery Phases of Acute Kidney Injury by Sinha, Vikash, Vence, Luis M., Salahudeen, Abdulla K.

“…Background Several biomarkers are becoming available for the early detection of acute kidney injury (AKI), but few have been directly compared. Objective To…”
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PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 2: comparative assessment of prediction methods of human volume of distribution by Jones, Rhys Do, Jones, Hannah M, Rowland, Malcolm, Gibson, Christopher R, Yates, James W T, Chien, Jenny Y, Ring, Barbara J, Adkison, Kimberly K, Ku, M Sherry, He, Handan, Vuppugalla, Ragini, Marathe, Punit, Fischer, Volker, Dutta, Sandeep, Sinha, Vikash K, Björnsson, Thorir, Lavé, Thierry, Poulin, Patrick

“…The objective of this study was to evaluate the performance of various empirical, semimechanistic and mechanistic methodologies with and without protein…”
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Retroperitoneal Bronchogenic Cyst: A Rare Case Study by Sinha, Vikash, Nandi, Partha, Shankar, Manu, Sardana, Nitin

“…Bronchogenic cyst usually presents along the tracheobronchial tree. Rarely, it is found inside peritoneal cavity. Here is a case of 30-year-old man who…”
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Artifact from myomectomy/C-Section on MRI images - what does this mean for MR-guided focused ultrasound candidacy for uterine fibroids? by Sinha, Vikash, Mehta, Shahil, Kalantzis, Georgios, Steinberg, Fred, LeBlang, Suzanne D

“…Background: Magnetic resonance-guided focused ultrasound (MRgFUS) is used for non-surgical treatment of uterine fibroids, often in patients who have had prior…”
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Retinal Artery Occlusion in Fibromuscular Dysplasia: A Case Report by Mehkri, Yusuf, Poe, Jordan, Murshid, Minaal, Hernandez, Jairo, Singh, Prashant, Sinha, Vikash N, Shuhaiber, Hans

“…Fibromuscular dysplasia (FMD) is a nonatherosclerotic, noninflammatory vasculopathy with no identifiable underlying cause. Clinical manifestations of the…”
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New Development of Variational Iteration Method Using Quasilinearization Method for Solving Nonlinear Problems by Sinha, Vikash Kumar, Maroju, Prashanth

“…In this paper, we developed a new variational iteration method using the quasilinearization method and Adomian polynomial to solve nonlinear differential…”
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Deep cerebral venous abnormalities in premature babies with GMH-IVH: a single-centre retrospective study by Kent, Thomas, Sinha, Vikash, Ceyhan, Elvan, Sura, Livia, Yekeler, Ensar, Weiss, Michael David, Albayram, Mehmet

“…PurposeGerminal matrix haemorrhage/intraventricular haemorrhage (GMH-IVH) is a multifactorial injury with both anatomic and haemodynamic involvement. Normal…”
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PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 4: prediction of plasma concentration-time profiles in human from in vivo preclinical data by using the Wajima approach by Vuppugalla, Ragini, Marathe, Punit, He, Handan, Jones, Rhys D O, Yates, James W T, Jones, Hannah M, Gibson, Christopher R, Chien, Jenny Y, Ring, Barbara J, Adkison, Kimberly K, Ku, M Sherry, Fischer, Volker, Dutta, Sandeep, Sinha, Vikash K, Björnsson, Thorir, Lavé, Thierry, Poulin, Patrick

“…The objective of this study was to evaluate the performance of the Wajima allometry (Css -MRT) approach published in the literature, which is used to predict…”
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A Rare Case of Epididymal Cyst Due to Schistosomiasis by Sinha, Vikash, Shankar, Manu, Sardana, Nitin, Aggarwal, Riti

“…Schistosomal epididymitis is a very rare condition. Worldwide, very few cases have been reported, especially in India. Here is a case of schistosomal…”
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The Prediction of Drug Metabolism, Tissue Distribution, and Bioavailability of 50 Structurally Diverse Compounds in Rat Using Mechanism-Based Absorption, Distribution, and Metabolism Prediction Tools by DE BUCK, Stefan S, SINHA, Vikash K, FENU, Luca A, GILISSEN, Ron A, MACKIE, Claire E, NIJSEN, Marjoleen J

“…The aim of this study was to assess a physiologically based modeling approach for predicting drug metabolism, tissue distribution, and bioavailability in rat…”
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Board Response to Transnational Regulation on Corporate Governance: A Case Study on EU Banking Regulation by Ikäheimo, Seppo, Schiehll, Eduardo, Sinha, Vikash Kumar

“…How does a board of directors respond to stringent transnational regulations on corporate governance? We explore this question in a case study that includes…”
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PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 1: goals, properties of the PhRMA dataset, and comparison with literature datasets by Poulin, Patrick, Jones, Hannah M, Jones, Rhys Do, Yates, James W T, Gibson, Christopher R, Chien, Jenny Y, Ring, Barbara J, Adkison, Kimberly K, He, Handan, Vuppugalla, Ragini, Marathe, Punit, Fischer, Volker, Dutta, Sandeep, Sinha, Vikash K, Björnsson, Thorir, Lavé, Thierry, Ku, M Sherry

“…This study is part of the Pharmaceutical Research and Manufacturers of America (PhRMA) initiative on predictive models of efficacy, safety, and compound…”
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Predicting Oral Clearance in Humans: How Close Can We Get with Allometry? by Sinha, Vikash K., De Buck, Stefan S., Fenu, Luca A., Smit, Johan W., Nijsen, Marjoleen, Gilissen, Ron A. H. J., Van Peer, Achiel, Lavrijsen, Karel, Mackie, Claire E.

“…Background Oral clearance (CL/F) is an important pharmacokinetic parameter and plays an important role in the selection of a safe and tolerable dose for…”
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Towards a Better Prediction of Peak Concentration, Volume of Distribution and Half-Life after Oral Drug Administration in Man, Using Allometry by Sinha, Vikash K., Vaarties, Karin, De Buck, Stefan S., Fenu, Luca. A., Nijsen, Marjoleen, Gilissen, Ron A. H. J., Sanderson, Wendy, Uytsel, Kelly Van, Hoeben, Eva, Peer, Achiel Van, Mackie, Claire E., Smit, Johan W.

“…Background: It is imperative that new drugs demonstrate adequate pharmacokinetic properties, allowing an optimal safety margin and convenient dosing regimens…”
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