Search Results - "Sinha, Uttam K"

The molecular mechanisms of increased radiosensitivity of HPV-positive oropharyngeal squamous cell carcinoma (OPSCC): an extensive review by Liu, Changxing, Mann, Daljit, Sinha, Uttam K, Kokot, Niels C

“…Head and neck carcinomas (HNCs) collectively are the sixth most common cancer with an annual incidence of about 400,000 cases in the US. The most…”
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Rationale for combined blockade of PD-1 and CTLA-4 in advanced head and neck squamous cell cancer – Review of current data by Swanson, Mark S, Sinha, Uttam K

“…Summary Targeted immunotherapy promoting anti-tumor T-cell activity has shown improved survival and durable objective responses in advanced melanoma patients…”
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Comprehensive analyses of partially methylated domains and differentially methylated regions in esophageal cancer reveal both cell-type- and cancer-specific epigenetic regulation by Zheng, Yueyuan, Ziman, Benjamin, Ho, Allen S, Sinha, Uttam K, Xu, Li-Yan, Li, En-Min, Koeffler, H Phillip, Berman, Benjamin P, Lin, De-Chen

“…As one of the most common malignancies, esophageal cancer has two subtypes, squamous cell carcinoma and adenocarcinoma, arising from distinct cells-of-origin…”
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Reciprocal inhibition between TP63 and STAT1 regulates anti-tumor immune response through interferon-γ signaling in squamous cancer by Jiang, Yuan, Zheng, Yueyuan, Zhang, Yuan-Wei, Kong, Shuai, Dong, Jinxiu, Wang, Fei, Ziman, Benjamin, Gery, Sigal, Hao, Jia-Jie, Zhou, Dan, Zhou, Jianian, Ho, Allen S., Sinha, Uttam K., Chen, Jian, Zhang, Shuo, Yin, Chuntong, Wei, Dan-Dan, Hazawa, Masaharu, Pan, Huaguang, Lu, Zhihao, Wei, Wen-Qiang, Wang, Ming-Rong, Koeffler, H. Phillip, Lin, De-Chen, Jiang, Yan-Yi

“…Squamous cell carcinomas (SCCs) are common and aggressive malignancies. Immune check point blockade (ICB) therapy using PD-1/PD-L1 antibodies has been approved…”
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Epigenomic analyses identify FOXM1 as a key regulator of anti-tumor immune response in esophageal adenocarcinoma by Ziman, Benjamin, Yang, Qian, Zheng, Yueyuan, Sheth, Megha, Nam, Chehyun, Zhao, Hua, Zhang, Le, Hu, Boyan, Bhowmick, Neil A., Sinha, Uttam K., Lin, De-Chen

“…Unlike most cancer types, the incidence of esophageal adenocarcinoma (EAC) has rapidly escalated in the western world over recent decades. Using whole genome…”
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Mechanisms of crosstalk between the oropharyngeal microbiome and human papillomavirus in oropharyngeal carcinogenesis: a mini review by Chung, Ryan S, Wong, Stephanie, Lin, Dechen, Kokot, Niels C, Sinha, Uttam K, Han, Albert Y

“…Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer globally. Notably, human papillomavirus (HPV)-positive oropharyngeal squamous…”
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The role of salivary cytokine biomarkers in tongue cancer invasion and mortality by Korostoff, Alexis, Reder, Lindsay, Masood, Rizwan, Sinha, Uttam K

“…Summary Squamous cell carcinoma of the tongue (TSCC) has one of the poorest prognoses of head and neck cancers. This study aims to improve early detection of…”
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Single-Cell Molecular Profiling of Head and Neck Squamous Cell Carcinoma Reveals Five Dysregulated Signaling Pathways Associated With Circulating Tumor Cells by Stucky, Andres, Viet, Chi T, Aouizerat, Bradley E, Ye, Yi, Doan, Coleen, Mundluru, Tarun, Sedhiazadeh, Parish, Sinha, Uttam K, Chen, Xuelian, Zhang, Xi, Li, Shengwen Calvin, Cai, Jin, Zhong, Jiang F

“…To determine the dysregulated signaling pathways of head and neck squamous cell carcinoma associated with circulating tumor cells (CTCs) via single-cell…”
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Use of Octreotide for the Management of Chyle Fistula Following Neck Dissection by Swanson, Mark S, Hudson, Rachael L, Bhandari, Nipun, Sinha, Uttam K, Maceri, Dennis R, Kokot, Niels

“…Chyle fistula is an uncommon complication of neck surgery. A variety of management strategies have been described, including diet restriction, parenteral…”
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Single-cell genomics identifies immune response to neoadjuvant chemoradiotherapy by Sinha, Uttam K., Kast, W. Martin, Lin, De-Chen

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Investigation of early neoplastic transformation and premalignant biology using genetically engineered organoid models by Zhao, Hua, Collet, Casey, Peng, Dongzi, Sinha, Uttam K., Lin, De-Chen

“…Organoid modeling is a powerful, robust and efficient technology faithfully preserving physiological and pathological characteristics of tissues of origin…”
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Effects of Steel Scalpel, Ultrasonic Scalpel, CO2 Laser, and Monopolar and Bipolar Electrosurgery on Wound Healing in Guinea Pig Oral Mucosa by Sinha, Uttam K., Gallagher, Laura A.

“…Objective The study's objective was to compare instrument performance and tissue healing when steel scalpel, ultrasonic scalpel, monopolar or bipolar…”
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The effect of human papillomavirus on DNA repair in head and neck squamous cell carcinoma by Low, Garren M., M.D, Thylur, David S., M.D, Yamamoto, Vicky, Ph.D, Sinha, Uttam K., M.D

“…Highlights • We discuss the influence of HPV on DNA repair processes in head and neck cancer. • Alterations in DNA repair by HPV contribute to…”
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Comparison of Free Flap Outcomes at a University Hospital versus County Hospital Setting for Head and Neck Reconstruction by Swanson, Mark S., Gantz, Oliver, Zhou, Sheng, Fisher, Laurel, Kezirian, Eric, Tan, Michael H., Zhang, Yanchen, Chambers, Tamara N., Sinha, Uttam K., Kokot, Niels

“…Abstract Introduction Patients at public county hospitals often have poorer access to healthcare with advanced disease on presentation. These factors, along…”
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Association of Race/Ethnicity, Stage, and Survival in Oral Cavity Squamous Cell Carcinoma: A SEER Study by Yu, Alison J., Choi, Janet S., Swanson, Mark S., Kokot, Niels C., Brown, Tamara N., Yan, Guofen, Sinha, Uttam K.

“…Objective Survival differences in oral cancer between black and white patients have been reported, but the contributing factors, especially the role of stage,…”
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Erratum to “The effect of human papillomavirus on DNA repair in head and neck squamous cell carcinoma” [Oral Oncol. 61 (2016) 27–30] by Low, Garren M., M.D, Thylur, David S., M.D, Yamamoto, Vicky, Ph.D, Sinha, Uttam K., M.D

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Enhanced Recovery After Surgery–Based Perioperative Protocol for Head and Neck Free Flap Reconstruction by Bertelsen, Caitlin, Hur, Kevin, Nurimba, Margaret, Choi, Janet, Acevedo, Joseph R., Jackanich, Anna, Sinha, Uttam K., Kochhar, Amit, Kokot, Niels, Swanson, Mark

“…Objectives Evaluate an enhanced recovery after surgery (ERAS)–based free flap management protocol implemented at our center. Study Design Prospective cohort…”
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EphB4 provides survival advantage to squamous cell carcinoma of the head and neck by Masood, Rizwan, Kumar, S. Ram, Sinha, Uttam K., Crowe, David L., Krasnoperov, Valery, Reddy, Ramachandra K., Zozulya, Sergey, Singh, Jasbir, Xia, Guangbin, Broek, Daniel, Schönthal, Axel H., Gill, Parkash S.

“…The receptor tyrosine kinase EphB4 and its ligand EphrinB2 play critical roles in blood vessel maturation, and are frequently overexpressed in a wide variety…”
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Management of Chyle Leak after Head and Neck Surgery: Review of Current Treatment Strategies by Sinha, Uttam K., Shokrani, Alireza, Shi, Haoran, Delaney, Sean W.

“…Chyle leak formation is an uncommon but serious sequela of head and neck surgery when the thoracic duct is inadvertently injured, particularly with the…”
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The supraclavicular artery island flap in head and neck reconstruction: applications and limitations by Kokot, Niels, Mazhar, Kashif, Reder, Lindsay S, Peng, Grace Lee, Sinha, Uttam K

“…The supraclavicular artery island (SAI) rotational flap may have advantages compared with free-tissue transfer in head and neck reconstruction. Because this…”
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