Search Results - "Sinha, Rohit A"

Direct effects of thyroid hormones on hepatic lipid metabolism by Sinha, Rohit A., Singh, Brijesh K., Yen, Paul M.

“…Key Points Thyroid hormones regulate hepatic lipid metabolism in a cell autonomous manner Thyroid hormone receptors (THRα and THRβ) differentially regulate…”
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Nonalcoholic Fatty Liver Disease and Hypercholesterolemia: Roles of Thyroid Hormones, Metabolites, and Agonists by Sinha, Rohit A, Bruinstroop, Eveline, Singh, Brijesh K, Yen, Paul M

“…Thyroid hormones (THs) exert a strong influence on mammalian lipid metabolism at the systemic and hepatic levels by virtue of their roles in regulating…”
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Thyroid hormone regulation of hepatic lipid and carbohydrate metabolism by Sinha, Rohit A, Singh, Brijesh K, Yen, Paul M

“…Highlights • Thyroid hormone induces hepatic lipogenesis and lipophagy. • Thyroid hormone increases reverse cholesterol transport. • Thyroid hormone regulates…”
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Thyroid Hormone-Mediated Selective Autophagy and Its Implications in Countering Metabolic Dysfunction-Associated Steatotic Liver Disease by Sinha, Rohit A

“…The influence of thyroid hormone (TH) on liver metabolism has attracted the attention of pharmacologists seeking new treatments for metabolic…”
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Thyroid hormone (T3) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy by Yau, Winifred W., Singh, Brijesh K., Lesmana, Ronny, Zhou, Jin, Sinha, Rohit A., Wong, Kiraely A., Wu, Yajun, Bay, Boon-Huat, Sugii, Shigeki, Sun, Lei, Yen, Paul M.

“…The thyroid hormone triiodothyronine (T 3 ) activates thermogenesis by uncoupling electron transport from ATP synthesis in brown adipose tissue (BAT)…”
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Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis by Widjaja, Anissa A., Singh, Brijesh K., Adami, Eleonora, Viswanathan, Sivakumar, Dong, Jinrui, D’Agostino, Giuseppe A., Ng, Benjamin, Lim, Wei Wen, Tan, Jessie, Paleja, Bhairav S., Tripathi, Madhulika, Lim, Sze Yun, Shekeran, Shamini Guna, Chothani, Sonia P., Rabes, Anne, Sombetzki, Martina, Bruinstroop, Eveline, Min, Lio Pei, Sinha, Rohit A., Albani, Salvatore, Yen, Paul M., Schafer, Sebastian, Cook, Stuart A.

“…We studied the role of interleukin 11 (IL11) signaling in the pathogenesis of nonalcoholic steatohepatitis (NASH) using hepatic stellate cells (HSCs),…”
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Targeting nuclear receptors for NASH/MASH: From bench to bedside by Sinha, Rohit A.

“…The onset of metabolic dysfunction-associated steatohepatitis (MASH) or non-alcoholic steatohepatitis (NASH) represents a tipping point leading to liver injury…”
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Caffeine stimulates hepatic lipid metabolism by the autophagy‐lysosomal pathway in mice by Sinha, Rohit A., Farah, Benjamin L., Singh, Brijesh K., Siddique, Monowarul M., Li, Ying, Wu, Yajun, Ilkayeva, Olga R., Gooding, Jessica, Ching, Jianhong, Zhou, Jin, Martinez, Laura, Xie, Sherwin, Bay, Boon‐Huat, Summers, Scott A., Newgard, Christopher B., Yen, Paul M.

“…Caffeine is one of the world's most consumed drugs. Recently, several studies showed that its consumption is associated with lower risk for nonalcoholic fatty…”
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Reciprocal crosstalk between autophagic and endocrine signaling in metabolic homeostasis by Sinha, Rohit A, Singh, Brijesh K, Yen, Paul M

“…Autophagy is a cellular quality control and energy-providing process that is under strict control by intra- and extra-cellular stimuli. Recently, there has…”
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Thyroid hormone induction of mitochondrial activity is coupled to mitophagy via ROS-AMPK-ULK1 signaling by Sinha, Rohit A, Singh, Brijesh K, Zhou, Jin, Wu, Yajun, Farah, Benjamin L, Ohba, Kenji, Lesmana, Ronny, Gooding, Jessica, Bay, Boon-Huat, Yen, Paul M

“…Currently, there is limited understanding about hormonal regulation of mitochondrial turnover. Thyroid hormone (T 3 ) increases oxidative phosphorylation…”
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Hepatic Lipid Catabolism via PPARα-Lysosomal Crosstalk by Sinha, Rohit A, Rajak, Sangam, Singh, Brijesh K, Yen, Paul M

“…Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors which belong to the nuclear hormone receptor superfamily. They…”
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Changes in macroautophagy, chaperone-mediated autophagy, and mitochondrial metabolism in murine skeletal and cardiac muscle during aging by Zhou, Jin, Chong, Shu Yun, Lim, Andrea, Singh, Brijesh K, Sinha, Rohit A, Salmon, Adam B, Yen, Paul M

“…Aging causes a general decline in cellular metabolic activity, and function in different tissues and whole body homeostasis. However, the understanding about…”
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Selective dietary polyphenols induce differentiation of human osteoblasts by adiponectin receptor 1-mediated reprogramming of mitochondrial energy metabolism by Pal, Subhashis, Porwal, Konica, Rajak, Sangam, Sinha, Rohit A., Chattopadhyay, Naibedya

“…•EGCG and resveratrol increase mitochondrial biogenesis and oxidative phosphorylation in human osteoblasts.•The osteogenic effect of these two nutrients…”
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The osteogenic effect of liraglutide involves enhanced mitochondrial biogenesis in osteoblasts by Pal, Subhashis, Maurya, Shailendra K., Chattopadhyay, Sourav, Pal China, Shyamsundar, Porwal, Konica, Kulkarni, Chirag, Sanyal, Sabyasachi, Sinha, Rohit A., Chattopadhyay, Naibedya

“…[Display omitted] Liraglutide (Lira), a long-acting glucagon-like peptide 1 receptor (GLP1R) agonist reduces glycosylated hemoglobin in type 2 diabetes…”
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MED1 mediator subunit is a key regulator of hepatic autophagy and lipid metabolism by Zhou, Jin, Singh, Brijesh K., Ho, Jia Pei, Lim, Andrea, Bruinstroop, Eveline, Ohba, Kenji, Sinha, Rohit A., Yen, Paul M.

“…Hepatic macroautophagy/autophagy and fatty acid metabolism are transcriptionally regulated by nuclear receptors (NRs); however, it is not known whether their…”
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Thyroid Hormone Stimulation of Autophagy Is Essential for Mitochondrial Biogenesis and Activity in Skeletal Muscle by Lesmana, Ronny, Sinha, Rohit A, Singh, Brijesh K, Zhou, Jin, Ohba, Kenji, Wu, Yajun, Yau, Winifred WY, Bay, Boon-Huat, Yen, Paul M

“…Thyroid hormone (TH) and autophagy share similar functions in regulating skeletal muscle growth, regeneration, and differentiation. Although TH recently has…”
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Vitamins and non-alcoholic fatty liver disease: A molecular insight by Raza, Sana, Tewari, Archana, Rajak, Sangam, Sinha, Rohit A.

“…The incidence of non-alcoholic fatty liver disease (NAFLD) is rising rapidly across the globe. NAFLD pathogenesis is largely driven by an imbalance in hepatic…”
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Maternal thyroid hormone deficiency affects the fetal neocorticogenesis by reducing the proliferating pool, rate of neurogenesis and indirect neurogenesis by Mohan, Vishwa, Sinha, Rohit A., Pathak, Amrita, Rastogi, Leena, Kumar, Praveen, Pal, Amit, Godbole, Madan M.

“…Neuronal progenitor cell proliferation and their optimum number are indispensable for neurogenesis, which is determined by cell cycle length and cell cycle…”
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Metabolomic analysis shows differential hepatic effects of T2 and T3 in rats after short-term feeding with high fat diet by Iannucci, Liliana F., Cioffi, Federica, Senese, Rosalba, Goglia, Fernando, Lanni, Antonia, Yen, Paul M., Sinha, Rohit A.

“…Nonalcoholic fatty liver disease (NAFLD) is a major health problem worldwide, and is often associated with lipotoxic injury, defective mitochondrial function,…”
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Short chain fatty acids induce UCP2-mediated autophagy in hepatic cells by Iannucci, Liliana F., Sun, Jingfeng, Singh, Brijesh K., Zhou, Jin, Kaddai, Vincent A., Lanni, Antonia, Yen, Paul M., Sinha, Rohit A.

“…Short-chain fatty acids (SCFAs) are gut microbial fermentation products derived from dietary fiber sources. Although depletion of gut microflora has been…”
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