Search Results - "Sinha, Dipali"

Crop Yield Prediction Using Improved Random Forest by T., Padma, Sinha, Dipali

“…Agriculture has an important role in India’s economic development. Crop productivity is affected by the rising population and the country’s ever-changing…”
Get full text

Mechanisms and specificity of factor XIa and trypsin inhibition by protease nexin 2 and basic pancreatic trypsin inhibitor by Navaneetham, Duraiswamy, Sinha, Dipali, Walsh, Peter N

“…Factor XIa (FXIa) inhibition by protease nexin-2 (PN2KPI) was compared with trypsin inhibition by basic pancreatic trypsin inhibitor (BPTI). PN2KPI was a…”
Get full text

The Amyloid Precursor Protein/Protease Nexin 2 Kunitz Inhibitor Domain Is a Highly Specific Substrate of Mesotrypsin by Salameh, Moh'd A., Robinson, Jessica L., Navaneetham, Duraiswamy, Sinha, Dipali, Madden, Benjamin J., Walsh, Peter N., Radisky, Evette S.

“…The amyloid precursor protein (APP) is a ubiquitously expressed transmembrane adhesion protein and the progenitor of amyloid-β peptides. The major splice…”
Get full text

Factor XI Homodimer Structure Is Essential for Normal Proteolytic Activation by Factor XIIa, Thrombin, and Factor XIa by Wu, Wenman, Sinha, Dipali, Shikov, Sergei, Yip, Calvin K., Walz, Thomas, Billings, Paul C., Lear, James D., Walsh, Peter N.

“…Coagulation factor XI (FXI) is a covalent homodimer consisting of two identical subunits of 80 kDa linked by a disulfide bond formed by Cys-321 within the…”
Get full text

P1 and P2' site mutations convert protease nexin-2 from a factor XIa inhibitor to a plasmin inhibitor by Navaneetham, Duraiswamy, Wu, Wenman, Li, Hongbo, Sinha, Dipali, Tuma, Ronald F, Walsh, Peter N

“…The kunitz protease inhibitor domain of PN2 (PN2KPI) is a potent and specific inhibitor (K(i) 0.5-2 nM) of factor XIa (FXIa) and inhibits cerebrovascular…”
Get full text

Macromolecular Substrate-Binding Exosites on Both the Heavy and Light Chains of Factor XIa Mediate the Formation of the Michaelis Complex Required for Factor IX-Activation by Sinha, Dipali, Marcinkiewicz, Mariola, Navaneetham, Duraiswamy, Walsh, Peter N

“…Binding of factor IX (FIX) to an exosite on the heavy chain of factor XIa (FXIa) is essential for the optimal activation of FIX (Sinha, D., Seaman, F. S., and…”
Get full text

Automatic epileptic signal classification using deep convolutional neural network by Sinha, Dipali, Thangavel, K.

“…Epilepsy is a neurological illness that causes seizures in the brain and affects a huge number of people worldwide. Electroencephalography (EEG) is the most…”
Get full text

15-deoxy-Δ12,14 prostaglandin J2 : A putative endogenous promoter of adipogenesis suppresses the ob gene by SINHA, D, ADDYA, S, MURER, E, BODEN, G

Get full text

Structural and Mutational Analysis of Canonical Loop Residues In Protease Nexin 2 Involved In Factor XIa and Trypsin Inhibition by Navaneetham, Duraiswamy, Sinha, Dipali, Walsh, Peter N.

“…Abstract 1147 Factor XIa (FXIa) activates FIX and is regulated by platelet-secreted protease nexin 2 (PN2) that contains a Kunitz-type protease inhibitor (KPI)…”
Get full text

Productive Recognition of Factor IX by Factor XIa Exosites Requires Disulfide Linkage between Heavy and Light Chains of Factor XIa by Marcinkiewicz, Mariola M., Sinha, Dipali, Walsh, Peter N.

“…In the intrinsic pathway of blood coagulation factor XIa (FXIa) activates factor IX (FIX) by cleaving the zymogen at Arg145-Ala146 and Arg180-Val181 bonds…”
Get full text

Localization of Ligand-Binding Exosites In the Catalytic Domain of Factor XIa by Su, Ya-Chi, Sinha, Dipali, Walsh, Peter N.

“…Abstract 1148 Coagulation factor XI (FXI) is a plasma zymogen that is activated to FXIa, the catalytic domain of which contains exosites that interact with its…”
Get full text

Determinants of Affinity and Proteolytic Stability in Interactions of Kunitz Family Protease Inhibitors with Mesotrypsin by Salameh, Moh'd A., Soares, Alexei S., Navaneetham, Duraiswamy, Sinha, Dipali, Walsh, Peter N., Radisky, Evette S.

“…An important functional property of protein protease inhibitors is their stability to proteolysis. Mesotrypsin is a human trypsin that has been implicated in…”
Get full text

The Role of the P1 Residue of Protease Nexin 2 and Basic Pancreatic Trypsin Inhibitor in the Mechanism of Factor XIa Inhibition by Navaneetham, Duraiswamy, Sinha, Dipali, Walsh, Peter N.

“…Factor XIa (FXIa), a plasma serine protease that activates FIX, is regulated by protease nexin 2 (PN2), a Kunitz-type protease inhibitor (KPI) secreted on…”
Get full text

Role of calcium ions and the heavy chain of factor XIa in the activation of human coagulation factor IX by Sinha, Dipali, Seaman, Frances S., Walsh, Peter N.

“…Since optimal rates of factor IX activation by factor XIa require the presence of calcium ions and the heavy chain of the enzyme as well as the…”
Get full text

The Role of Factor XIa (FXIa) Catalytic Domain Exosite Residues in Substrate Catalysis and Inhibition by the Kunitz Protease Inhibitor Domain of Protease Nexin 2 by Su, Ya-Chi, Miller, Tara N., Navaneetham, Duraiswamy, Schoonmaker, Robert T., Sinha, Dipali, Walsh, Peter N.

“…To select residues in coagulation factor XIa (FXIa) potentially important for substrate and inhibitor interactions, we examined the crystal structure of the…”
Get full text

Functional Domains in the Heavy-Chain Region of Factor XI: A High Molecular Weight Kininogen-Binding Site and a Substrate-Binding Site for Factor IX by Baglia, Frank A., Sinha, Dipali, Walsh, Peter N.

“…To probe the molecular interactions of factor XI we have prepared two monoclonal antibodies (MoAbs; 5F7 and 3C1), each of which binds the heavy chain of…”
Get full text

A Catalytic Domain Exosite (Cys527−Cys542) in Factor XIa Mediates Binding to a Site on Activated Platelets by Miller, Tara N, Sinha, Dipali, Baird, T. Regan, Walsh, Peter N

“…The zymogen, factor XI, and the enzyme, factor XIa, interact specifically with functional receptors on the surface of activated platelets. These studies were…”
Get full text

Isolation and characterization of two protease inhibitors from bovine plasma by Sinha, D, Yang, X, Emig, F, Kirby, E P

“…Two protease inhibitors (Inh2 and Inh3) from bovine plasma have been isolated and characterized. The apparent molecular weights of the two proteins are 56 and…”
Get more information

Traffic Signal Violation Detection System using YOLOv3 by Sinha, Dipali, Divya, S., Anjali, C., Keethigha, R. K.

“…The quantity of vehicles on the road is progressively escalating, resulting in heavily congested roads. This could result in many accidents. Computer vision…”
Get full text

Factor XI Homodimer Formation Is Mediated by Electrostatic (Lys331 with Glu287) and Hydrophobic (Ile290 with Leu284 and Tyr329 with Tyr329) Interactions in the Apple 4 Domain and Is Essential for Normal Proteolytic Activation of Factor XI by Factor XIIa, Thrombin and Factor XIa by Wu, Wenman, Sinha, Dipali, Lear, James D., Billings, Paul C., Walsh, Peter N.

“…Factor XI (FXI), a coagulation protein essential for normal hemostasis, is a homodimer consisting of two identical subunits of 80 KDa linked by a disulfide…”
Get full text