Search Results - "Sinha, Animesh A"

Autoantibody Signaling in Pemphigus Vulgaris: Development of an Integrated Model by Sajda, Thomas, Sinha, Animesh A

“…Pemphigus vulgaris (PV) is an autoimmune skin blistering disease effecting both cutaneous and mucosal epithelia. Blister formation in PV is known to result…”
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Patient genetics shape the autoimmune response in the blistering skin disease pemphigus vulgaris by Baker, John, Seiffert-Sinha, Kristina, Sinha, Animesh A

“…Pemphigus vulgaris (PV) is known to have one of the strongest HLA associations among autoimmune diseases. DRB1*0402 and DQB1*0503 in particular are…”
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Worldwide epidemiologic factors in pemphigus vulgaris and bullous pemphigoid by Rosi-Schumacher, Mattie, Baker, John, Waris, James, Seiffert-Sinha, Kristina, Sinha, Animesh A

“…Autoimmune blistering diseases such as bullous pemphigoid (BP) and pemphigus vulgaris (PV) are complex, multifactorial, and polygenic diseases, whose exact…”
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The Evolving Story of Autoantibodies in Pemphigus Vulgaris: Development of the "Super Compensation Hypothesis" by Sinha, Animesh A, Sajda, Thomas

“…Emerging data and innovative technologies are re-shaping our understanding of the scope and specificity of the autoimmune response in Pemphigus vulgaris (PV),…”
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A Retrospective Study of Patient-Reported Data of Bullous Pemphigoid and Mucous Membrane Pemphigoid From a US-Based Registry by Lee, Janet, Seiffert-Sinha, Kristina, Attwood, Kristopher, Sinha, Animesh A

“…Bullous pemphigoid (BP) and mucous membrane pemphigoid (MMP) are rare chronic autoimmune disorders characterized by subepidermal blistering. For the United…”
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In silico Analyses of Skin and Peripheral Blood Transcriptional Data in Cutaneous Lupus Reveals CCR2-A Novel Potential Therapeutic Target by Dey-Rao, Rama, Sinha, Animesh A

“…Cutaneous lesions feature prominently in lupus erythematosus (LE). Yet lupus and its cutaneous manifestations exhibit extraordinary clinical heterogeneity,…”
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Desmoglein compensation hypothesis fidelity assessment in Pemphigus by Sielski, Lauren, Baker, John, DePasquale, Michael C., Attwood, Kristopher, Seiffert-Sinha, Kristina, Sinha, Animesh A.

“…The pemphigus group of autoimmune blistering diseases encompasses pemphigus vulgaris (PV) and pemphigus foliaceus (PF). Lesion location in pemphigus has been…”
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The multifactorial complexities of autoimmune development in Pemphigus vulgaris: Critical evaluation of the role of environmental and lifestyle "exposome" factors by Adebiyi, Olumayowa T, Galloway, Dominique F, Augustin, Michael S, Sinha, Animesh A

“…Pemphigus vulgaris (PV) is a potentially life-threatening blistering disorder characterized by autoantibodies directed against cell-cell adhesion molecules…”
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Multiplexed autoantigen microarrays identify HLA as a key driver of anti-desmoglein and -non-desmoglein reactivities in pemphigus by Sajda, Thomas, Hazelton, Julian, Patel, Milan, Seiffert-Sinha, Kristina, Steinman, Lawrence, Robinson, William, Haab, Brian B., Sinha, Animesh A.

“…Patients with pemphigus vulgaris (PV) harbor antibodies reactive against self-antigens expressed at the surface of keratinocytes, primarily desmoglein (Dsg) 3…”
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Monopathogenic vs multipathogenic explanations of pemphigus pathophysiology by Ahmed, A. Razzaque, Carrozzo, Marco, Caux, Frédéric, Cirillo, Nicola, Dmochowski, Marian, Alonso, Agustín España, Gniadecki, Robert, Hertl, Michael, López-Zabalza, Maria J., Lotti, Roberta, Pincelli, Carlo, Pittelkow, Mark, Schmidt, Enno, Sinha, Animesh A., Sprecher, Eli, Grando, Sergei A.

“…This viewpoint highlights major, partly controversial concepts about the pathogenesis of pemphigus. The monopathogenic theory explains intra‐epidermal…”
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The Genetics of Pemphigus by Sinha, Animesh A., MD, PhD

“…Pemphigus vulgaris (PV) is an autoimmune blistering disorder with a complex etiology involving an interplay of genetic as well as environmental factors, most…”
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Paraneoplastic Pemphigus: Autoimmune-Cancer Nexus in the Skin by Sinha, Animesh A

“…Paraneoplastic pemphigus (PNP) is a debilitating and lethal adult and pediatric autoimmune blistering skin disease that occurs in the setting of a known or…”
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Inheritance-Specific Dysregulation of Th1- and Th17-Associated Cytokines in Alopecia Areata by Van Acker, Monica M, Schwartz, Rebekah R, Andrews, Kelly, Seiffert-Sinha, Kristina, Sinha, Animesh A

“…Autoimmune diseases tend to cluster in families, suggesting genetic predisposition to autoimmunity associated with familial background. We have previously…”
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Transcriptional profiling in alopecia areata defines immune and cell cycle control related genes within disease-specific signatures by Subramanya, Raghunandan Dudda, Coda, Alvin B., Sinha, Animesh A.

“…Alopecia areata (AA) is a non-scarring inflammatory hair loss disease with a complex autoimmune etiopathogenesis that is poorly understood. In order to…”
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Anti-Thyroid Peroxidase Reactivity Is Heightened in Pemphigus Vulgaris and Is Driven by Human Leukocyte Antigen Status and the Absence of Desmoglein Reactivity by Seiffert-Sinha, Kristina, Khan, Shahzaib, Attwood, Kristopher, Gerlach, John A, Sinha, Animesh A

“…Pemphigus vulgaris (PV) belongs to an autoimmune disease cluster that includes autoimmune thyroid disease (AITD), suggesting common mechanisms driving…”
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Cellular level robotic surgery: Nanodissection of intermediate filaments in live keratinocytes by Yang, Ruiguo, PhD, Song, Bo, MEng, Sun, Zhiyong, MEng, Lai, King Wai Chiu, PhD, Fung, Carmen Kar Man, PhD, Patterson, Kevin C., MD, Seiffert-Sinha, Kristina, MD, Sinha, Animesh A., MD, PhD, Xi, Ning, DSc

“…Abstract We present the nanosurgery on the cytoskeleton of live cells using AFM based nanorobotics to achieve adhesiolysis and mimic the effect of…”
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Checking autoimmune genetic risk to stratify immune checkpoint inhibitor responders by Sinha, Animesh A.

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Nanorobotic investigation identifies novel visual, structural and functional correlates of autoimmune pathology in a blistering skin disease model by Seiffert-Sinha, Kristina, Yang, Ruiguo, Fung, Carmen K, Lai, King W, Patterson, Kevin C, Payne, Aimee S, Xi, Ning, Sinha, Animesh A

“…There remain major gaps in our knowledge regarding the detailed mechanisms by which autoantibodies mediate damage at the tissue level. We have undertaken novel…”
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Smoking behavior and association of melanoma and nonmelanoma skin cancer in the Women's Health Initiative by Henderson, Michael T., BA, Kubo, Jessica T., MS, Desai, Manisha, PhD, David, Sean P., MD, DPhil, Tindle, Hilary, MD, MPH, Sinha, Animesh A., MD, PhD, Seiffert-Sinha, Kristina, MD, Hou, Lifang, MD, MS, PhD, Messina, Catherine, PhD, Saquib, Nazmus, PhD, Stefanick, Marcia L., PhD, Tang, Jean Y., MD, PhD

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Investigation of human keratinocyte cell adhesion using atomic force microscopy by Fung, Carmen Kar Man, PhD, Seiffert-Sinha, Kristina, MD, Lai, King Wai Chiu, PhD, Yang, Ruiguo, MEng, Panyard, Dan, Zhang, Jiangbo, PhD, Xi, Ning, DSc, Sinha, Animesh A., MD, PhD

“…Abstract Desmosomal junctions are specialized structures critical to cellular adhesion within epithelial tissues. Disassembly of these junctions is seen…”
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