Search Results - "Sinha, Amit U."

Chromatin-modifying enzymes as modulators of reprogramming by Onder, Tamer T., Kara, Nergis, Cherry, Anne, Sinha, Amit U., Zhu, Nan, Bernt, Kathrin M., Cahan, Patrick, Mancarci, B. Ogan, Unternaehrer, Juli, Gupta, Piyush B., Lander, Eric S., Armstrong, Scott A., Daley, George Q.

“…Inhibition of DOT1L, the H3K79 histone methyltransferase, increases cell reprogramming and substituted for KLF4 and c-Myc, showing that chromatin-modifying…”
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Polycomb repressive complex 2 is required for MLL-AF9 leukemia by Neff, Tobias, Sinha, Amit U, Kluk, Michael J, Zhu, Nan, Khattab, Mohamed H, Stein, Lauren, Xie, Huafeng, Orkin, Stuart H, Armstrong, Scott A

“…A growing body of data suggests the importance of epigenetic mechanisms in cancer. Polycomb repressive complex 2 (PRC2) has been implicated in self-renewal and…”
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AF10 Regulates Progressive H3K79 Methylation and HOX Gene Expression in Diverse AML Subtypes by Deshpande, Aniruddha J., Deshpande, Anagha, Sinha, Amit U., Chen, Liying, Chang, Jenny, Cihan, Ali, Fazio, Maurizio, Chen, Chun-wei, Zhu, Nan, Koche, Richard, Dzhekieva, Liuda, Ibáñez, Gloria, Dias, Stuart, Banka, Deepti, Krivtsov, Andrei, Luo, Minkui, Roeder, Robert G., Bradner, James E., Bernt, Kathrin M., Armstrong, Scott A.

“…Homeotic (HOX) genes are dysregulated in multiple malignancies, including several AML subtypes. We demonstrate that H3K79 dimethylation (H3K79me2) is converted…”
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Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l by Deshpande, Aniruddha J., Chen, Liying, Fazio, Maurizio, Sinha, Amit U., Bernt, Kathrin M., Banka, Deepti, Dias, Stuart, Chang, Jenny, Olhava, Edward J., Daigle, Scott R., Richon, Victoria M., Pollock, Roy M., Armstrong, Scott A.

“…The t(6;11)(q27;q23) is a recurrent chromosomal rearrangement that encodes the MLLAF6 fusion oncoprotein and is observed in patients with diverse hematologic…”
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mTOR Complex 1 Plays Critical Roles in Hematopoiesis and Pten-Loss-Evoked Leukemogenesis by Kalaitzidis, Demetrios, Sykes, Stephen M., Wang, Zhu, Punt, Natalie, Tang, Yuefeng, Ragu, Christine, Sinha, Amit U., Lane, Steven W., Souza, Amanda L., Clish, Clary B., Anastasiou, Dimitrios, Gilliland, D. Gary, Scadden, David T., Guertin, David A., Armstrong, Scott A.

“…The mechanistic target of rapamycin (mTOR) pathway serves as a key sensor of cellular-energetic state and functions to maintain tissue homeostasis…”
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Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains by Trowbridge, Jennifer J, Sinha, Amit U, Zhu, Nan, Li, Mingjie, Armstrong, Scott A, Orkin, Stuart H

“…Epigenetic mechanisms regulating leukemia stem cells (LSCs) are an attractive target for therapy of blood cancers. Here, we report that conditional knockout of…”
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Cinteny: flexible analysis and visualization of synteny and genome rearrangements in multiple organisms by Sinha, Amit U, Meller, Jaroslaw

“…Identifying syntenic regions, i.e., blocks of genes or other markers with evolutionary conserved order, and quantifying evolutionary relatedness between…”
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MLL-AF9- and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C by Zhu, Nan, Chen, Mo, Eng, Rowena, DeJong, Joshua, Sinha, Amit U, Rahnamay, Noushin F, Koche, Richard, Al-Shahrour, Fatima, Minehart, Janna C, Chen, Chun-Wei, Deshpande, Aniruddha J, Xu, Haiming, Chu, S Haihua, Ebert, Benjamin L, Roeder, Robert G, Armstrong, Scott A

“…Self-renewal is a hallmark of both hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs); therefore, the identification of mechanisms that are…”
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MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L by Bernt, Kathrin M., Zhu, Nan, Sinha, Amit U., Vempati, Sridhar, Faber, Joerg, Krivtsov, Andrei V., Feng, Zhaohui, Punt, Natalie, Daigle, Amanda, Bullinger, Lars, Pollock, Roy M., Richon, Victoria M., Kung, Andrew L., Armstrong, Scott A.

“…The histone 3 lysine 79 (H3K79) methyltransferase Dot1l has been implicated in the development of leukemias bearing translocations of the Mixed Lineage…”
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iCanPlot: visual exploration of high-throughput omics data using interactive Canvas plotting by Sinha, Amit U, Armstrong, Scott A

“…Increasing use of high throughput genomic scale assays requires effective visualization and analysis techniques to facilitate data interpretation. Moreover,…”
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MLL-Rearranged B Lymphoblastic Leukemias Selectively Express the Immunoregulatory Carbohydrate-Binding Protein Galectin-1 by JUSZCZYNSKI, Przemyslaw, RODIG, Scott J, FABER, Joerg, SINHA, Amit U, RABINOVICH, Gabriel A, ARMSTRONG, Scott A, KUTOK, Jeffery L, SHIPP, Margaret A, JING OUYANG, O'DONNELL, Evan, TAKEYAMA, Kunihiko, MLYNARSKI, Wojciech, MYCKO, Katarzyna, SZCZEPANSKI, Tomasz, GAWORCZYK, Anna, KRIVTSOV, Andrei

“…Patients with mixed lineage leukemia (MLL)-rearranged B-lymphoblastic leukemias (B-ALL) have an unfavorable prognosis and require intensified treatment…”
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Dissecting microregulation of a master regulatory network by Sinha, Amit U, Kaimal, Vivek, Chen, Jing, Jegga, Anil G

“…The master regulator p53 tumor-suppressor protein through coordination of several downstream target genes and upstream transcription factors controls many…”
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eXframe: reusable framework for storage, analysis and visualization of genomics experiments by Sinha, Amit U, Merrill, Emily, Armstrong, Scott A, Clark, Tim W, Das, Sudeshna

“…Genome-wide experiments are routinely conducted to measure gene expression, DNA-protein interactions and epigenetic status. Structured metadata for these…”
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Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms by Jayavelu, Ashok Kumar, Schnöder, Tina M., Perner, Florian, Herzog, Carolin, Meiler, Arno, Krishnamoorthy, Gurumoorthy, Huber, Nicolas, Mohr, Juliane, Edelmann-Stephan, Bärbel, Austin, Rebecca, Brandt, Sabine, Palandri, Francesca, Schröder, Nicolas, Isermann, Berend, Edlich, Frank, Sinha, Amit U., Ungelenk, Martin, Hübner, Christian A., Zeiser, Robert, Rahmig, Susann, Waskow, Claudia, Coldham, Iain, Ernst, Thomas, Hochhaus, Andreas, Jilg, Stefanie, Jost, Philipp J., Mullally, Ann, Bullinger, Lars, Mertens, Peter R., Lane, Steven W., Mann, Matthias, Heidel, Florian H.

“…Janus kinases (JAKs) mediate responses to cytokines, hormones and growth factors in haematopoietic cells 1 , 2 . The JAK gene JAK2 is frequently mutated in the…”
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Wnt/β-Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML by Wang, Yingzi, Krivtsov, Andrei V, Sinha, Amit U, North, Trista E, Goessling, Wolfram, Feng, Zhaohui, Zon, Leonard I, Armstrong, Scott A

“…Leukemia stem cells (LSCs) are capable of limitless self-renewal and are responsible for the maintenance of leukemia. Because selective eradication of LSCs…”
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Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia by Mar, Brenton G., Bullinger, Lars B., McLean, Kathleen M., Grauman, Peter V., Harris, Marian H., Stevenson, Kristen, Neuberg, Donna S., Sinha, Amit U., Sallan, Stephen E., Silverman, Lewis B., Kung, Andrew L., Lo Nigro, Luca, Ebert, Benjamin L., Armstrong, Scott A.

“…Relapsed paediatric acute lymphoblastic leukaemia (ALL) has high rates of treatment failure. Epigenetic regulators have been proposed as modulators of…”
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H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias by Krivtsov, Andrei V., Feng, Zhaohui, Lemieux, Madeleine E., Faber, Joerg, Vempati, Sridhar, Sinha, Amit U., Xia, Xiaobo, Jesneck, Jonathan, Bracken, Adrian P., Silverman, Lewis B., Kutok, Jeffery L., Kung, Andrew L., Armstrong, Scott A.

“…We created a mouse model wherein conditional expression of an Mll-AF4 fusion oncogene induces B precursor acute lymphoblastic (ALL) or acute myeloid leukemias…”
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A noncanonical enzymatic function of PIWIL4 maintains genomic integrity and leukemic growth in AML by Bamezai, Shiva, Pulikkottil, Alex Jose, Yadav, Tribhuwan, Vegi, Naidu M., Mueller, Julia, Mark, Jasmin, Mandal, Tamoghna, Feder, Kristin, Ihme, Susann, Song, Chenlin, Rosler, Reinhild, Wiese, Sebastian, Hoell, Jessica I., Kloetgen, Andreas, Karsan, Aly, Kumari, Ankita, Wojenski, Luke, Sinha, Amit U., Gonzalez-Menendez, Irene, Quintanilla-Martinez, Leticia, Donato, Elisa, Trumpp, Andreas, Kruse, Elisabeth, Hamperl, Stephan, Zou, Lee, Rawat, Vijay P. S., Buske, Christian

“…•The RNase H–like superfamily member PIWIL4 is required for leukemic stem cell function but dispensable for human hematopoietic stem cells.•PIWIL4 prevents…”
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MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia by Riedel, Simone S, Haladyna, Jessica N, Bezzant, Matthew, Stevens, Brett, Pollyea, Daniel A, Sinha, Amit U, Armstrong, Scott A, Wei, Qi, Pollock, Roy M, Daigle, Scott R, Jordan, Craig T, Ernst, Patricia, Neff, Tobias, Bernt, Kathrin M

“…Meningioma-1 (MN1) overexpression is frequently observed in patients with acute myeloid leukemia (AML) and is predictive of poor prognosis. In murine models,…”
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DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia by Chen, Chun-Wei, Koche, Richard P, Sinha, Amit U, Deshpande, Aniruddha J, Zhu, Nan, Eng, Rowena, Doench, John G, Xu, Haiming, Chu, Scott H, Qi, Jun, Wang, Xi, Delaney, Christopher, Bernt, Kathrin M, Root, David E, Hahn, William C, Bradner, James E, Armstrong, Scott A

“…The authors uncover the mechanism by which DOTL1 exerts its role as an epigenetic regulator required for leukemic progression by counteracting the effects of…”
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