Search Results - "Singleton, Kristen D."

Glutamine's protection against sepsis and lung injury is dependent on heat shock protein 70 expression by Singleton, Kristen D, Wischmeyer, Paul E

“…Glutamine (GLN) has been shown to protect against inflammatory injury and illness in experimental and clinical settings. The mechanism of this protection is…”
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Oral glutamine enhances heat shock protein expression and improves survival following hyperthermia by SINGLETON, Kristen D, WISCHMEYER, Paul E

“…No pharmacologic agent has shown benefit in treating heatstroke. Previous data indicate that enhanced heat shock protein 70 (HSP-70) expression can improve…”
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Effects of HSP70.1/3 gene knockout on acute respiratory distress syndrome and the inflammatory response following sepsis by Singleton, Kristen D, Wischmeyer, Paul E

“…Heat shock response has been implicated in attenuating NF-kappaB activation and inflammation following sepsis. Studies utilizing sublethal heat stress or…”
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Glutamine's protection against cellular injury is dependent on heat shock factor-1 by Morrison, Angela L, Dinges, Martin, Singleton, Kristen D, Odoms, Kelli, Wong, Hector R, Wischmeyer, Paul E

“…Glutamine (GLN) has been shown to protect cells, tissues, and whole organisms from stress and injury. Enhanced expression of heat shock protein (HSP) has been…”
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Glutamine Donor Pretreatment in Rat Kidney Transplants with Severe Preservation Reperfusion Injury by Fuller, T. Florian, M.D, Rose, Florian, M.D, Singleton, Kristen D., M.S, Linde, Yvonne, B.S, Hoff, Uwe, M.D, Freise, Chris E., M.D, Dragun, Duska, Ph.D, Niemann, Claus U., M.D

“…Background Glutamine (GLN) has been shown to confer cytoprotection by enhancing endogenous heat shock protein (HSP) expression. We hypothesized that GLN donor…”
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Glutamine attenuates lung injury and improves survival after sepsis: Role of enhanced heat shock protein expression by Singleton, Kristen D, Serkova, Natalie, Beckey, Virgina E, Wischmeyer, Paul E

“…OBJECTIVE:Heat shock protein (HSP) expression is vital to cellular and tissue protection after stress or injury. However, application of this powerful tool in…”
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Glutamine prevents activation of NF-κB and stress kinase pathways, attenuates inflammatory cytokine release, and prevents acute respiratory distress syndrome (ARDS) following sepsis by SINGLETON, Kristen D, BECKEY, Virginia E, WISCHMEYER, Paul E

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Parenteral glutamine increases serum heat shock protein 70 in critically ill patients by ZIEGLER, Thomas R, OGDEN, Lorraine G, SINGLETON, Kristen D, MENGHUA LUO, FERNANDEZ-ESTIVARIZ, Concepcion, GRIFFITH, Daniel P, GALLOWAY, John R, WISCHMEYER, Paul E

“…Heat shock protein 70 (HSP-70) is protective against cellular and tissue injury. Increased serum HSP-70 levels are associated with decreased mortality in…”
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Glutamine Induces Heat Shock Protein Expression Via O-Glycosylation and Phosphorylation of HSF-1 and Sp1 by Singleton, Kristen D., Wischmeyer, Paul E.

“…Background: Glutamine (GLN) improves outcome in experimental and clinical states of illness and injury. The authors hypothesized GLN-mediated enhancement of…”
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Glutamine attenuates tumor necrosis factor-α release and enhances heat shock protein 72 in human peripheral blood mononuclear cells by Wischmeyer, Paul E, Riehm, Jacob, Singleton, Kristen D, Ren, Hongyu, Musch, Mark W, Kahana, Madelyn, Chang, Eugene B

“…Overexpression of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α) can contribute to multiple organ dysfunction syndrome and septic shock in…”
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Glutamine attenuates endotoxin-induced lung metabolic dysfunction: Potential role of enhanced heat shock protein 70 by Singleton, Kristen D., Serkova, Natalie, Banerjee, Anirban, Meng, Xianzhong, Gamboni-Robertson, Fabia, Wischmeyer, Paul E.

“…Septic shock leads to derangement of cellular metabolism. Enhanced heat shock protein 70 (HSP-70) can preserve cellular metabolism after other forms of…”
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Single dose of glutamine enhances myocardial tissue metabolism, glutathione content, and improves myocardial function after ischemia-reperfusion injury by Wischmeyer, PE, Jayakar, D, Williams, U, Singleton, KD, Riehm, J, Bacha, EA, Jeevanandam, V, Christians, U, Serkova, N

“…BACKGROUND: Myocardial ischemia and reperfusion (I/R) injury causes significant morbidity and mortality. Protection against I/R injury may occur via…”
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Glutamine attenuates inflammation and NF-κB activation via Cullin-1 deneddylation by Singleton, Kristen D., Wischmeyer, Paul E.

“…Glutamine (GLN) can inhibit NF-kΒ activation and cytokine expression following sepsis. NF-κB activation and inflammatory cytokine expression, depend on…”
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Glutamine Attenuates Inflammation and NF-kB Activation Via Cullin-1 Deneddylation by Singleton, Kristen D., Wischmeyer, Paul E.

“…Glutamine (GLN) can inhibit NF-kB activation and cytokine expression following sepsis. NF-kB activation and inflammatory cytokine expression, depend on…”
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HSP-70 KNOCK-OUT MICE DEMONSTRATE ENHANCED NF-KB ACTIVATION AND MORTALITY FOLLOWING SEPSIS: 110-T by Singleton, Kristen D, Wischmeyer, Paul E

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ORAL GLUTAMINE DECREASES GUT PERMEABILITY AND IMPROVES SURVIVAL FOLLOWING HEAT STROKE: ROLE OF HEAT SHOCK PROTEIN EXPRESSION: 129-S by Singleton, Kristen D, Wischmeyer, Paul E

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GLUTAMINE PREVENTS ACTIVATION OF NF-kappaB AND STRESS KINASE PATHWAYS, ATTENUATES INFLAMMATORY CYTOKINE RELEASE, AND PREVENTS ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) FOLLOWING SEPSIS by Singleton, Kristen D, Beckey, Virginia E, Wischmeyer, Paul E

“…Glutamine (GLN) has been shown to attenuate cytokine release from LPS-stimulated human peripheral blood mononuclear cells; however, the in vivo…”
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MORTALITY FOLLOWING CECAL LIGATION AND DOUBLE PUNCTURE ARE DEPENDENT ON LENGTH OF CECUM LIGATED: 255 by Singleton, Kristen D, Wischmeyer, Paul E

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POST-TREATMENT WITH SINGLE DOSE OF GLUTAMINE ATTENUATES IL-18 EXPRESSION AND REDUCES POLYMICROBIAL SEPSIS-INDUCED MORTALITY: 39 by Wischmeyer, Paul E, Singleton, Kristen D

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Glutamine attenuates inflammation and NF-kappaB activation via Cullin-1 deneddylation by Singleton, Kristen D, Wischmeyer, Paul E

“…Glutamine (GLN) can inhibit NF-kBeta activation and cytokine expression following sepsis. NF-kappaB activation and inflammatory cytokine expression, depend on…”
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