Search Results - "Singleton, John T"

The uses of pincer complexes in organic synthesis by Singleton, John T.

“…Pincer complexes consist of a tridentate skeleton bound to a metal by at least one metal–carbon σ bond. The highly protected environment for the resident metal…”
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Efficient Syntheses of AZD4407 via Thioether Formation by Nucleophilic Attack of Organometallic Species on Sulphur by Alcaraz, Marie-Lyne, Atkinson, Stéphanie, Cornwall, Philip, Foster, Alison C, Gill, Duncan M, Humphries, Lesley A, Keegan, Philip S, Kemp, Richard, Merifield, Eric, Nixon, Robert A, Noble, Allison J, O'Beirne, Darren, Patel, Zakariya M, Perkins, Jacob, Rowan, Paul, Sadler, Paul, Singleton, John T, Tornos, James, Watts, Andrew J, Woodland, Ian A

“…The development of two efficient strategies for the synthesis of AZD4407 is reported, both of which are considered suitable for large-scale manufacture. In the…”
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Routes for the Synthesis of (2S)-2-Methyltetrahydropyran-4-one from Simple Optically Pure Building Blocks by Anderson, Kevin R, Atkinson, Stéphanie L. G, Fujiwara, Takahiro, Giles, Melvyn E, Matsumoto, Takaji, Merifield, Eric, Singleton, John T, Saito, Takao, Sotoguchi, Tsukasa, Tornos, James A, Way, Edward L

“…Routes to (2S)-2-methyltetrahydropyran-4-one of high optical purity starting from readily available chiral pool precursors and suitable for large-scale…”
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A Convergent Synthesis of AR-C123196 Utilising Reaction Between a Cyclic Carbonate and a Phenol for Aryl Alkyl Ether Formation by Allsop, Glyn L, Cole, Andrea J, Giles, Melvyn E, Merifield, Eric, Noble, Allison J, Pritchett, Michael A, Purdie, Lindsay A, Singleton, John T

“…The development of a convergent synthesis of AR-C123196 is reported in which the alkyl aryl ether linkage was formed by nucleophilic attack of a phenolic…”
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A general and efficient route to 6-methyl-pyrazin-2-yl-amines: Alkylation of 2,6-dichloropyrazine via malonate derivatives by Colbon, Paul J. J., Foster, Alison C., Giles, Melvyn E., Patel, Zakariya, Singleton, John T.

“…We have developed a convenient two‐stage process for the synthesis of 6‐methylpyrazine‐2‐yl‐amines from commercially available materials. The procedure…”
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Development of a Manufacturing Process for Sibenadet Hydrochloride, the Active Ingredient of Viozan by Giles, Melvyn E., Thomson, Colin, Eyley, Stephen C., Cole, Andrea J., Goodwin, Christopher J., Hurved, Paul A., Morlin, Andrew J. G., Tornos, James, Atkinson, Stéphanie, Just, Cecelia, Dean, Janet C., Singleton, John T., Longton, Andrew J., Woodland, Ian, Teasdale, Andrew, Gregertsen, Björn, Else, Howard, Athwal, Mandip S., Tatterton, Stephen, Knott, Jason M., Thompson, Nicola, Smith, Stephen J.

“…A process for commercial manufacture of the dual D2-β2 receptor agonist sibenadet hydrochloride has been developed. The process relies upon introduction of…”
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