Search Results - "Singhal, PC"

Morphine-Induced Degradation of the Host Defense Barrier: Role of Macrophage Injury by Bhaskaran, Madhu, Reddy, Krishna, Sharma, Saroj, Singh, Jasjeet, Radhakrishnan, Neetu, Kapasi, Aditi, Singhal, Pravin C.

“…The effect of morphine on the degradation of the host defense barrier in rats and mice was studied. Mice received either 3 or 11 doses of morphine. Mice…”
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Morphine-induced macrophage apoptosis modulates migration of macrophages: use of in vitro model of urinary tract infection by Malik, Aftab A, Radhakrishnan, Neetu, Reddy, Krishna, Smith, Arthur D, Singhal, Pravin C

“…Morphine has been reported to alter immune function. Morphine-induced macrophage apoptosis has been shown to contribute to altered immune status in an opiate…”
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The Molecular Mechanism of Renal Tubulointerstitial Inflammation Promoting Diabetic Nephropathy by Xue, Rui, Xiao, Haiting, Kumar, Vinod, Lan, Xiqian, Malhotra, Ashwani, Singhal, Pravin C, Chen, Jianning

“…Diabetic nephropathy (DN) is a common complication affecting many diabetic patients, leading to end-stage renal disease. However, its pathogenesis still needs…”
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Angiotensin II induces apoptosis in renal proximal tubular cells by Bhaskaran, Madhu, Reddy, Krishna, Radhakrishanan, Neetu, Franki, Nicholas, Ding, Guohua, Singhal, Pravin C

“…ANG II has been demonstrated to play a role in the progression of tubulointerstial injury. We studied the direct effect of ANG II on apoptosis of cultured rat…”
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Angiotensin II induces apoptosis in rat glomerular epithelial cells by Ding, Guohua, Reddy, Krishna, Kapasi, Aditi A, Franki, Nicholas, Gibbons, Nora, Kasinath, Balakuntalam S, Singhal, Pravin C

“…ANG II has been shown to modulate kidney cell growth and contribute to the pathobiology of glomerulosclerosis. Glomerular visceral epithelial cell (GEC) injury…”
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MicroRNAs in HIV-associated nephropathy (HIVAN) by Cheng, Kang, Rai, Partab, Plagov, Andrei, Lan, Xiqian, Subrati, Ashaan, Husain, Mohammad, Malhotra, Ashwani, Singhal, Pravin C.

“…MicroRNAs (miRNAs) play a critical role in multiple biological and metabolic processes. Recent studies suggested that miRNAs are critical in the maintenance of…”
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Endocytosis of light chains induces cytokines through activation of NF-κB in human proximal tubule cells by Sengul, Sule, Zwizinski, Craig, Simon, Eric E., Kapasi, Aditi, Singhal, Pravin C., Batuman, Vecihi

“…Endocytosis of light chains induces cytokines through activation of NF-κB in human proximal tubule cells. In proteinuric states increased cytokine production…”
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Morphine-induced macrophage apoptosis: oxidative stress and strategies for modulation by Bhat, Rajani S., Bhaskaran, Madhu, Mongia, Anil, Hitosugi, Naoko, Singhal, Pravin C.

“…Occurrence of macrophage apoptosis has been implicated for the altered immune function found in an opiate milieu. In the present study, we evaluated the role…”
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Angiotensin II-induced mesangial cell apoptosis: role of oxidative stress by Lodha, Saurabh, Dani, Dhimant, Mehta, Rajeev, Bhaskaran, Madhu, Reddy, Krishna, Ding, Guohua, Singhal, Pravin C

“…Angiotensin II (ANG II) has been shown to play a role in the induction of glomerular injury. In the present study, we evaluated the effects of ANG II on…”
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Morphine Enhances Macrophage Apoptosis by Singhal, Pravin C, Sharma, Puneet, Kapasi, Aditi A, Reddy, Krishna, Franki, Nicholas, Gibbons, Nora

“…Laboratory data indicate that morphine decreases the numbier of peritoneal and alveolar macrophages (Mphi) and compromises their phagocytic capability for…”
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Role of oxidative stress and heme oxygenase activity in morphine-induced glomerular epithelial cell growth by Patel, Jaimita, Manjappa, Nagarathna, Bhat, Rajani, Mehrotra, Pavni, Bhaskaran, Madhu, Singhal, Pravin C

“…Opiate addiction has been reported to contribute to the progression of renal injury. In addition, opiate addiction is a major risk factor for the development…”
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Role of P38 Mitogen-Activated Protein Kinase Phosphorylation and Fas-Fas Ligand Interaction in Morphine-Induced Macrophage Apoptosis by Singhal, Pravin C, Bhaskaran, Madhu, Patel, Jaimita, Patel, Kalpesh, Kasinath, Balakuntalam S, Duraisamy, Senthil, Franki, Nicholas, Reddy, Krishna, Kapasi, Aditi A

“…In this study, we evaluated the molecular mechanisms involved in morphine-induced macrophage apoptosis. Both morphine and TGF-beta promoted P38…”
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Immunomodulatory effect of morphine: therapeutic implications by Dinda, Amit, Gitman, Michael, Singhal, Pravin C

“…The immunosuppressive as well as modulatory effects of morphine have been known in clinical medicine for > 100 years. Recent developments in molecular…”
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Morphine-induced degradation of the host defense barrier : Role of intestinal mucosal injury by FRENKLAKH, Lia, BHAT, Rajani S, BHASKARAN, Madhu, SHARMA, Shilpa, SHARMA, Meera, DINDA, Amit, SINGHAL, Pravin C

“…The effect of morphine on intestinal ulcer formation and on the degradation of the host defense barrier was studied. Mice receiving morphine (MRM) showed…”
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Ethanol promotes T cell apoptosis through the mitochondrial pathway by Kapasi, Aditi A., Patel, Geeta, Goenka, Anuj, Nahar, Nilay, Modi, Neeraj, Bhaskaran, Madhu, Reddy, Krishna, Franki, Nicholas, Patel, Jaimita, Singhal, Pravin C.

“…Summary Clinical reports suggest that acute ethanol intoxication is often associated with lymphopenia. Previously, ethanol was reported to invoke thymocyte…”
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Ethanol-induced macrophage apoptosis: the role of TGF-beta by Singhal, P C, Reddy, K, Ding, G, Kapasi, A, Franki, N, Ranjan, R, Nwakoby, I E, Gibbons, N

“…Both clinical and laboratory reports indicate that ethanol addicts are prone to recurrent infections. We hypothesize that ethanol promotes macrophage…”
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Morphine modulates proliferation of kidney fibroblasts by Singhal, Pravin C., Sharma, Pratima, Sanwal, Vibha, Prasad, Abhinav, Kapasi, Aditi, Ranjan, Rajiv, Franki, Nicholas, Reddy, Krishna, Gibbons, Nora

“…Morphine modulates proliferation of kidney fibroblasts. Renal interstitial scarring is an important component of heroin-associated nephropathy. Kidney…”
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Emerging strategies for lowering serum phosphorous in patients with end-stage renal disease by Ashfaq, Akhtar, Gitman, Michael, Singhal, Pravin C

“…Hyperphosphataemia is a major problem in patients with chronic kidney disease as it has been associated with increased morbidity and mortality. Over the last…”
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Protease inhibitors modulate apoptosis in mesangial cells derived from a mouse model of HIVAN by MONGIA, Anil, BHASKARAN, Madhu, REDDY, Krishna, MANJAPPA, Nagarathna, BAQI, Noosha, SINGHAL, Pravin C

“…Oxidative stress as well as opiate addiction has been shown to play a role in the development of complications associated with human immunodeficiency virus…”
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HIV-1 gp120-induced tubular epithelial cell apoptosis is mediated through p38-MAPK phosphorylation by Kapasi, Aditi A, Patel, Geeta, Franki, Nicholas, Singhal, Pravin C

“…HIV-associated nephropathy is accompanied by significant tubular alterations in the form of tubular cell proliferation, apoptosis, and microcystic dilatation…”
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