Search Results - "Singhal, P C"

Aging phenotype(s) in kidneys of diabetic mice are p66ShcA dependent by Vashistha, H, Marrero, L, Reiss, K, Cohen, A J, Malhotra, A, Javed, T, Bradley, A, Abbruscato, F, Giusti, S, Jimenez, A, Mehra, S, Kaushal, D, Giorgio, M, Pelicci, P G, Kakoki, M, Singhal, P C, Bunnell, B, Meggs, L G

“…The p66ShcA protein controls cellular responses to oxidative stress, senescence, and apoptosis. Here, we test the hypothesis that aging phenotype(s) commonly…”
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Morphine modulates proliferation of kidney fibroblasts by Singhal, Pravin C., Sharma, Pratima, Sanwal, Vibha, Prasad, Abhinav, Kapasi, Aditi, Ranjan, Rajiv, Franki, Nicholas, Reddy, Krishna, Gibbons, Nora

“…Morphine modulates proliferation of kidney fibroblasts. Renal interstitial scarring is an important component of heroin-associated nephropathy. Kidney…”
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Morphine‐induced macrophage apoptosis: the role of transforming growth factor‐β by Singhal, P. C., Kapasi, A. A., Franki, N., Reddy, K.

“…Summary Laboratory and clinical reports indicate that opiate addicts are prone to infections. This effect of opiates is partly attributed to opiate‐induced…”
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DC-specific ICAM-3-grabbing nonintegrin mediates internalization of HIV-1 into human podocytes by Mikulak, J, Teichberg, S, Arora, S, Kumar, D, Yadav, A, Salhan, D, Pullagura, S, Mathieson, P W, Saleem, M A, Singhal, P C

“…Human immunodeficiency virus (HIV)-1 has been demonstrated to contribute to the pathogenesis of HIV-associated nephropathy. In renal biopsy studies, podocytes…”
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Peroxynitrite formation and apoptosis in transgenic sickle cell mouse kidneys by Bank, Norman, Kiroycheva, Militza, Ahmed, Fayyaz, Anthony, Gillian M., Fabry, Mary E., Nagel, Ronald L., Singhal, Pravin C.

“…Peroxynitrite formation and apoptosis in transgenic sickle cell mouse kidneys. In a previous study, nitric oxide synthases (NOS) were found to be strongly…”
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Morphine-Induced Degradation of the Host Defense Barrier: Role of Macrophage Injury by Bhaskaran, Madhu, Reddy, Krishna, Sharma, Saroj, Singh, Jasjeet, Radhakrishnan, Neetu, Kapasi, Aditi, Singhal, Pravin C.

“…The effect of morphine on the degradation of the host defense barrier in rats and mice was studied. Mice received either 3 or 11 doses of morphine. Mice…”
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Leukocyte-polytetrafluoroethylene interaction enhances proliferation of vascular smooth muscle cells via tumor necrosis factor-α secretion by Mattana, Joseph, Effiong, Charles, Kapasi, Aditi, Singhal, Pravin C.

“…Leukocyte-polytetrafluoroethylene interaction enhances proliferation of vascular smooth muscle cells via tumor necrosis factor-α secretion. Intimal hyperplasia…”
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Lymphopenia in dialysis patients: a preliminary study indicating a possible role of apoptosis by Bhaskaran, M, Ranjan, R, Shah, H, Siu, J, Colvin, R, Radhakrishnan, N, Reddy, K, Franki, N, Wagner, J D, Singhal, P C

“…Lymphopenia is a common finding in dialysis patients. Since infection rate and mortality associated with infection are high in dialysis patients, lymphopenia…”
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Effects of atrial natriuretic peptide and cGMP on uptake of IgG complexes by macrophages by Mattana, J, Singhal, P C

“…Macromolecular handling by macrophages and glomerular mesangial cells may be important in the development of renal injury. We undertook the present study to…”
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Inhibition of nitric oxide synthase ameliorates cellular injury in sickle cell mouse kidneys by Bank, Norman, Kiroycheva, Militza, Singhal, Pravin C., Anthony, Gillian M., Southan, Garry J., Szabo, Csaba

“…Inhibition of nitric oxide synthase ameliorates cellular injury in sickle cell mouse kidneys. In previous studies of transgenic sickle cell mice, increased…”
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Disparate effects of eplerenone, amlodipine and telmisartan on podocyte injury in aldosterone-infused rats by WEI LIANG, CHENG CHEN, JING SHI, ZHILONG REN, FENGQI HU, VAN GOOR, Harry, SINGHAL, Pravin C, GUOHUA DING

“…Several studies in patients with primary aldosteronism (PA) have suggested that aldosterone (ALD) is directly contributing to albuminuria. However, there are…”
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Cocaine interacts with macrophages to modulate mesangial cell proliferation by Mattana, J, Gibbons, N, Singhal, P C

“…Human immunodeficiency virus infection is associated with the development of focal segmental glomerulosclerosis (FSGS). The majority of these patients with…”
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Monocyte apoptosis in dialysis patients is Fas ligand-mediated by Ranjan, R, Shah, H, Siu, J, Varghese, E, Bhaskaran, M, Reddy, K, Kapasi, A A, Wagner, J D, Singhal, P C

“…The mononuclear phagocyte system plays an important role in host defense. Since dialysis patients have been reported to show enhanced leukocytes apoptosis, we…”
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Long term effects of morphine on mesangial cell proliferation and matrix synthesis by Singhal, Pravin C., Gibbons, Nora, Abramovici, Mirel

“…Long term effects of morphine on mesangial cell proliferation and matrix synthesis. Since focal glomerulosclerosis is the predominant glomerular lesion in…”
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Dialysis membrane-induced neutrophil apoptosis is mediated through free radicals by Nahar, N, Shah, H, Siu, J, Colvin, R, Bhaskaran, M, Ranjan, R, Wagner, J D, Singhal, P C

“…Patients on hemodialysis are prone to infection. Neutrophils are the host's first line of defense against certain invading pathogenic microorganisms. Since…”
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Laboratory abnormalities in patients with bacterial pneumonia by Sankaran, R T, Mattana, J, Pollack, S, Bhat, P, Ahuja, T, Patel, A, Singhal, P C

“…This study was undertaken to evaluate the laboratory abnormalities observed in patients with bacterial pneumonia as predictors of the severity of illness…”
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Repetitive mechanical strain suppresses macrophage uptake of immunoglobulin G complexes and enhances cyclic adenosine monophosphate synthesis by Mattana, J, Sankaran, RT, Singhal, PC

“…Uptake of immunoglobulin G (IgG) complexes by macrophages (M phi) may play an important role in disease states characterized by increased levels of circulating…”
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Determinants of elevated creatine kinase activity and creatine kinase MB-fraction following cardiopulmonary resuscitation by Mattana, J, Singhal, P C

“…We undertook this study to determine the occurrence and the determinants of elevation of serum creatine kinase (CK) levels and CK MB-fraction following…”
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Ethanol-induced neutrophil apoptosis is mediated through nitric oxide by Singhal, P C, Patel, P, Nàhàr, N, Franki, N, Kapasi, A, Reddy, K, Shah, N, Nwakoby, I E, Mehrotra, B

“…Clinical reports indicate that acute ethanol intoxication in chronic ethanol abusers is associated with neutropenia. We hypothesize that ethanol accelerates…”
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Heparin attenuates the effect of mitogenic vasoconstrictors on mesangial cell proliferation and handling of immunoglobulin G complexes by Mattana, J, Singhal, P C

“…Angiotensin II (ANG II) and endothelin-1 (ET-1) may both play significant roles in causing mesangial expansion and glomerulosclerosis after renal injury by…”
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