Search Results - "Singhal, Nishant"

Generation of integration-free Down syndrome and isogenic euploid human induced pluripotent stem cells by Nehra, Sunita, Sharma, Vishi, Umrani, Malati, Singhal, Nishant

“…A pair of Down syndrome (DS) human iPSCs (hiPSCs) and isogenic euploid hiPSCs generated by using an integration-free Sendai viral vector system showed trisomy…”
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Generation of AAVS1-EGFP reporter cell lines from an isogenic pair of trisomy 21 and euploid human iPSCs by Sharma, Vishi, Nehra, Sunita, Singhal, Nishant

“…Human mouse chimeric models are valuable tools to develop in-vivo disease models. However, in-vivo detection of human cells limits their analysis. To…”
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Chromatin-Remodeling Components of the BAF Complex Facilitate Reprogramming by Singhal, Nishant, Graumann, Johannes, Wu, Guangming, Araúzo-Bravo, Marcos J., Han, Dong Wook, Greber, Boris, Gentile, Luca, Mann, Matthias, Schöler, Hans R.

“…Reprogramming of somatic cells achieved by combination of the four transcription factors Oct4, Sox2, Klf4, and c-Myc has very low efficiency. To increase the…”
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Editorial: Down syndrome: Genetic and epigenetic influences on this multi-faceted condition by Ghosh, Sujay, Jackson-Cook, Colleen, Singhal, Nishant, Hui, Subhra Prakash

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Generation of integration free hiPSCs clones, NSi001-A, NSi001-B, and NSi001-C from peripheral blood mononuclear cells of an individual with down syndrome having Robertsonian translocation by Nehra, Sunita, Sharma, Vishi, Singh, Mool, Singhal, Paresh, Singhal, Nishant

“…Human-induced pluripotent stem cells (hiPSCs) clones NSi001-A, NSi001-B, and NSi001-C were generated from a female individual of Indian origin having…”
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Biphasic cell cycle defect causes impaired neurogenesis in down syndrome by Sharma, Vishi, Nehra, Sunita, Do, Long H., Ghosh, Anwesha, Deshpande, Aniruddha J., Singhal, Nishant

“…Impaired neurogenesis in Down syndrome (DS) is characterized by reduced neurons, increased glial cells, and delayed cortical lamination. However, the…”
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Epigenetic modifier alpha-ketoglutarate modulates aberrant gene body methylation and hydroxymethylation marks in diabetic heart by Dhat, Rohini, Mongad, Dattatray, Raji, Sivarupa, Arkat, Silpa, Mahapatra, Nitish R, Singhal, Nishant, Sitasawad, Sandhya L

“…Diabetic cardiomyopathy (DCM) is a leading cause of death in diabetic patients. Hyperglycemic myocardial microenvironment significantly alters chromatin…”
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An Anti-β-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome by Belichenko, Pavel V, Madani, Rime, Rey-Bellet, Lorianne, Pihlgren, Maria, Becker, Ann, Plassard, Adeline, Vuillermot, Stephanie, Giriens, Valérie, Nosheny, Rachel L, Kleschevnikov, Alexander M, Valletta, Janice S, Bengtsson, Sara K S, Linke, Gordon R, Maloney, Michael T, Hickman, David T, Reis, Pedro, Granet, Anne, Mlaki, Dorin, Lopez-Deber, Maria Pilar, Do, Long, Singhal, Nishant, Masliah, Eliezer, Pearn, Matthew L, Pfeifer, Andrea, Muhs, Andreas, Mobley, William C

“…In Down syndrome (DS) or trisomy of chromosome 21, the β-amyloid (Aβ) peptide product of the amyloid precursor protein (APP) is present in excess. Evidence…”
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Brg1 chromatin remodeling ATPase balances germ layer patterning by amplifying the transcriptional burst at midblastula transition by Wagner, Gabriele, Singhal, Nishant, Nicetto, Dario, Straub, Tobias, Kremmer, Elisabeth, Rupp, Ralph A W

“…Zygotic gene expression programs control cell differentiation in vertebrate development. In Xenopus, these programs are initiated by local induction of…”
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Questioned validity of Gene Expression Dysregulated Domains in Down's Syndrome by Do, Long H, Mobley, William C, Singhal, Nishant

“…Recently, in studies examining fibroblasts obtained from the tissues of one set of monozygotic twins (i.e. fetuses derived from the same egg) discordant for…”
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BRG1 Is Required to Maintain Pluripotency of Murine Embryonic Stem Cells by Singhal, Nishant, Esch, Daniel, Stehling, Martin, Schöler, Hans R

“…BAF chromatin remodeling complexes containing the BRG1 protein have been shown to be not only essential for early embryonic development, but also paramount in…”
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Establishment of totipotency does not depend on Oct4A by Wu, Guangming, Han, Dong, Gong, Yu, Sebastiano, Vittorio, Gentile, Luca, Singhal, Nishant, Adachi, Kenjiro, Fischedick, Gerrit, Ortmeier, Claudia, Sinn, Martina, Radstaak, Martina, Tomilin, Alexey, Schöler, Hans R.

“…Oct4 is a core component of the regulatory network of pluripotency. Schöler and colleagues found that establishment of totipotency was not affected by genetic…”
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MicroRNA‐221 regulates FAS‐induced fulminant liver failure by Sharma, Amar Deep, Narain, Nidhi, Händel, Eva‐Maria, Iken, Marcus, Singhal, Nishant, Cathomen, Toni, Manns, Michael P., Schöler, Hans R., Ott, Michael, Cantz, Tobias

“…Death receptor‐mediated apoptosis of hepatocytes contributes to hepatitis and fulminant liver failure. MicroRNAs (miRNAs), 19‐25 nucleotide‐long noncoding…”
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An Anti-[beta]-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome by Belichenko, Pavel V, Madani, Rime, Rey-Bellet, Lorianne, Pihlgren, Maria, Becker, Ann, Plassard, Adeline, Vuillermot, Stephanie, Giriens, Valérie, Nosheny, Rachel L, Kleschevnikov, Alexander M, Valletta, Janice S, Bengtsson, Sara K. S, Linke, Gordon R, Maloney, Michael T, Hickman, David T, Reis, Pedro, Granet, Anne, Mlaki, Dorin, Lopez-Deber, Maria Pilar, Do, Long, Singhal, Nishant, Masliah, Eliezer, Pearn, Matthew L, Pfeifer, Andrea, Muhs, Andreas, Mobley, William C

“…In Down syndrome (DS) or trisomy of chromosome 21, the [beta]-amyloid (A[beta]) peptide product of the amyloid precursor protein (APP) is present in excess…”
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Genetic modulation of self renewal factors for induced reprogramming of somatic cells by Zaehres, Holm, Do, Jeong Tae, Singhal, Nishant, Tapia, Natalia, Han, Dong Wook, Schöler, Hans

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When the embryonic genome flexes its muscles: Chromatin and myogenic transcription regulation by Rupp, Ralph A. W., Singhal, Nishant, Veenstra, Gert Jan C.

“…During the development of multicellular organisms, both transient and stable gene expression patterns have to be established in a precisely orchestrated…”
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When the embryonic genome flexes its muscles by Rupp, Ralph A. W., Singhal, Nishant, Veenstra, Gert Jan C.

“…During the development of multicellular organisms, both transient and stable gene expression patterns have to be established in a precisely orchestrated…”
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