Search Results - "Singha, Netai"

Tumor-associated hyaluronan limits efficacy of monoclonal antibody therapy by Singha, Netai C, Nekoroski, Tara, Zhao, Chunmei, Symons, Rebecca, Jiang, Ping, Frost, Gregory I, Huang, Zhongdong, Shepard, H Michael

“…Despite tremendous progress in cancer immunotherapy for solid tumors, clinical success of monoclonal antibody (mAb) therapy is often limited by poorly…”
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Accumulation of Extracellular Hyaluronan by Hyaluronan Synthase 3 Promotes Tumor Growth and Modulates the Pancreatic Cancer Microenvironment by Singha, Netai C., Zhao, Chunmei, Kultti, Anne, Zimmerman, Susan, Osgood, Ryan J., Symons, Rebecca, Jiang, Ping, Li, Xiaoming, Thompson, Curtis B., Infante, Jeffrey R., Jacobetz, Michael A., Tuveson, David A., Frost, Gregory I., Shepard, H. Michael, Huang, Zhongdong

“…Extensive accumulation of the glycosaminoglycan hyaluronan is found in pancreatic cancer. The role of hyaluronan synthases 2 and 3 (HAS2, 3) was investigated…”
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Regulation of TIP60 by ATF2 Modulates ATM Activation by Bhoumik, Anindita, Singha, Netai, O'Connell, Matthew J., Ronai, Ze'ev A.

“…TIP60 (HTATIP) is a histone acetyltransferase (HAT) whose function is critical in regulating ataxia-telangiectasia mutated (ATM) activation, gene expression,…”
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A Direct Interaction between the RAG2 C Terminus and the Core Histones Is Required for Efficient V(D)J Recombination by West, Kelly L., Singha, Netai C., De Ioannes, Pablo, Lacomis, Lynne, Erdjument-Bromage, Hediye, Tempst, Paul, Cortes, Patricia

“…V(D)J recombination is a tightly controlled process of somatic recombination whose regulation is mediated in part by chromatin structure. Here, we report that…”
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Critical Function for SIP, a Ubiquitin E3 Ligase Component of the β-Catenin Degradation Pathway, for Thymocyte Development and G1 Checkpoint by Fukushima, Toru, Zapata, Juan M., Singha, Netai C., Thomas, Michael, Kress, Christina L., Krajewska, Maryla, Krajewski, Stan, Ronai, Ze'ev, Reed, John C., Matsuzawa, Shu-ichi

“…β-catenin has been implicated in thymocyte development because of its function as a coactivator of Tcf/LEF-family transcription factors. Previously, we…”
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Real-time Kinetics of the Interaction between the Two Subunits, Escherichia coli Thioredoxin and Gene 5 Protein of Phage T7 DNA Polymerase by Singha, Netai C., Vlamis-Gardikas, Alexios, Holmgren, Arne

“…T7 phage DNA polymerase is a tight 1:1 complex of the gene 5 protein (g5p) (80 kDa) of phage T7 and thioredoxin (12 kDa) from the Escherichia coli host. The…”
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Ku70/Ku80 and DNA-dependent protein kinase catalytic subunit modulate RAG-mediated cleavage: implications for the enforcement of the 12/23 rule by Sawchuk, Dennis J, Mansilla-Soto, Jorge, Alarcon, Claudio, Singha, Netai C, Langen, Hanno, Bianchi, Marco E, Lees-Miller, Susan P, Nussenzweig, Michel C, Cortes, Patricia

“…The 12/23 rule is a critical step for regulation of V(D)J recombination. To date, only the RAG proteins and high mobility group protein 1 or 2 have been…”
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Molecular Cloning and Characterization of a Mouse Homolog of Bacterial ClpX, a Novel Mammalian Class II Member of the Hsp100/Clp Chaperone Family by Santagata, S, Bhattacharyya, D, Wang, F H, Singha, N, Hodtsev, A, Spanopoulou, E

“…In this paper, we present the molecular cloning and characterization of a murine homolog of the Escherichia coli chaperone ClpX. Murine ClpX shares 38% amino…”
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Proton and carbon-13 NMR studies of conformational preferences in N-(2-pyridinyl)-2-pyridinecarboxamides by Singha, Netai C, Sathyanarayana, D.N

“…The 1H and 13C NMR spectra, molecular conformation and intermolecular association of N-(2-pyridinyl)-2- pyridinecarboxamides and 2-pyridinecarboxamide are…”
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Differential scanning calorimetric studies of the glycoprotein, winged bean acidic lectin, isolated from the seeds of Psophocarpus tetrogonolobus by Srinivas, V.R, Singha, Netai C, Schwarz, Fredrick P, Surolia, Avadhesa

“…Differential scanning calorimetry of solutions of WBAII and in presence of sugar ligands shows that WBAII dimer dissociates to its constituent monomeric…”
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Abstract 982: Hyaluronan (HA) depletion increases tumor accessibility of T cell and therapeutic PD-L1 monoclonal antibody in HAhigh tumors by Singha, Netai C., Zhao, Chunmei, Bahn, Jesse, Radi, Adrian, Shepard, H. Michael, Huang, Zhongdong

“…Tumor initiation and progression is a complex interaction between host and tumor. One of the essential elements for tumor progression is evasion of the host…”
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Abstract P5-04-02: Hyaluronan (HA) depletion sensitizes HAhigh tumors to antibody-dependent cell-mediated cytotoxicity by Singha, Netai C, Nekoroski, Tara, Zhao, Chunmei, Symons, Rebecca, Jiang, Ping, Frost, Gregory, Huang, Zhongdong, Shepard, H Michael

“…Therapeutic efficacy of monoclonal antibodies (MAbs) against solid tumor targets, like trastuzumab (anti-HER2) and cetuximab (anti-EGFR), have been used…”
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Ku70/Ku80 and DNA-dependent Protein Kinase Catalytic Subunit Modulate RAG-mediated Cleavage by Sawchuk, Dennis J., Mansilla-Soto, Jorge, Alarcon, Claudio, Singha, Netai C., Langen, Hanno, Bianchi, Marco E., Lees-Miller, Susan P., Nussenzweig, Michel C., Cortes, Patricia

“…The 12/23 rule is a critical step for regulation of V(D)J recombination. To date, only the RAG proteins and high mobility group protein 1 or 2 have been…”
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Localized agglutinin staining in muscle capillaries from normal and very old atrophic human muscle using winged bean (Psophocarpus tetragonolobus) lectin by Kirkeby, S, Singha, N C, Surolia, A

“…The winged bean (Psophocarpus tetragonolobus) agglutinin (total lectin) and its basic (WBA I) and acidic isoform (WBA II) were used to analyze capillaries in…”
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Abstract B6: PEGPH20 depletion of pericellular hyaluronan sensitizes high hyaluronan-producing tumor cells in antibody-dependent cell-mediated cytotoxicity by Singha, Netai C., Jiang, Ping, Zimmerman, Susan, Connor, Robert, Frost, Gregory I., Huang, Zhongdong, Shepard, H. Michael

“…Monoclonal antibodies (MAbs) have been developed successfully as part of the anticancer armamentarium. However, even in cases where the target of the antibody…”
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Abstract 4999: Hyaluronan-rich ECM contributes to resistance to antibody-dependent cell-mediated cytotoxicity in solid tumors by Singha, Netai C., Nekoroski, Tara, Zimmerman, Susan, Zhao, Chunmei, Jiang, Ping, Connor, Robert, Frost, Gregory I., Huang, Zhondong, Shepard, Michael H.

“…Accumulation of Hyaluronan (HA), an important glycosaminoglycan of the extracellular matrix (ECM), has been detected in about 25% of human tumors, and 56% of…”
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Abstract 3665: Enzymatic depletion of pericellular HA from tumor cell surface sensitizes Erbitux dependent immune cell-mediated cytotoxicity by Singha, Netai C., Jiang, Ping, Frost, Gregory I., Shepard, H Michael

“…Hyaluronan (HA), a ubiquitous high-molar-mass linear glycosaminoglycan (GAG) plays a critical role in cell adhesion, motility, growth and differentiation. HA…”
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1H and 13C NMR investigations of N, N′-bis(2- and 3-pyridinyl)-2,6-pyridine dicarboxamides by Singha, Netai C., Sathyanarayana, D.N.

“…1H NMR spectra of N, N′-bis(2-pyridinyl)-2,6-pyridinedicarboxamides (1 to 3) and N, N′-bis(3-pyridinyl)-2,6-pyridinedicarboxamide shifts and coupling constants…”
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Regulation of TIP60 by ATF2 Modulates ATM ActivationS by Bhoumik, Anindita, Singha, Netai, O'Connell, Matthew J., Ronai, Ze'ev A.

“…TIP60 (HTATIP) is a histone acetyltransferase (HAT) whose function is critical in regulating ataxia-telangiectasia mutated (ATM) activation, gene expression,…”
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NMR study of the conformation of N-(3-pyridinyl)-2-pyridinecarboxamide, N-(3-pyridinyl)acetamide and 2-pyridinecarboxamide by Anand, Jayashree, Singha, Netai C., Sathyanarayana, D.N.

“…The 1H NMR spectra of N-(3-pyridinyl)-2-pyridinecarboxamide (1), N-(3-pyridinyl)acetamide (2) and 2-pyridinecarboxamide (3) in CDCl 3, (CD 3) 2CO and CD 3CN…”
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