Search Results - "Singh, Yajuvinder"

An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo by Keuters, Meike Hedwig, Keksa-Goldsteine, Velta, Dhungana, Hiramani, Huuskonen, Mikko T., Pomeshchik, Yuriy, Savchenko, Ekaterina, Korhonen, Paula K., Singh, Yajuvinder, Wojciechowski, Sara, Lehtonen, Šárka, Kanninen, Katja M., Malm, Tarja, Sirviö, Jouni, Muona, Anu, Koistinaho, Milla, Goldsteins, Gundars, Koistinaho, Jari

“…Lipid peroxidation-initiated ferroptosis is an iron-dependent mechanism of programmed cell death taking place in neurological diseases. Here we show that a…”
Get full text

Retinal Degeneration In A Mouse Model Of CLN5 Disease Is Associated With Compromised Autophagy by Leinonen, Henri, Keksa-Goldsteine, Velta, Ragauskas, Symantas, Kohlmann, Philip, Singh, Yajuvinder, Savchenko, Ekaterina, Puranen, Jooseppi, Malm, Tarja, Kalesnykas, Giedrius, Koistinaho, Jari, Tanila, Heikki, Kanninen, Katja M.

“…The Finnish variant of late infantile neuronal ceroid lipofuscinosis (CLN5 disease) belongs to a family of neuronal ceroid lipofuscinosis (NCLs) diseases…”
Get full text

High tumor mutation burden predicts favorable outcome among patients with aggressive histological subtypes of lung adenocarcinoma: A population-based single-institution study by Talvitie, Eva-Maria, Vilhonen, Heikki, Kurki, Samu, Karlsson, Antti, Orte, Katri, Almangush, Alhadi, Mohamed, Hesham, Liljeroos, Lassi, Singh, Yajuvinder, Leivo, Ilmo, Laitinen, Tarja, Kallajoki, Markku, Taimen, Pekka

“…Tumor mutation burden (TMB) is an emerging predictive cancer biomarker. Few studies have addressed the prognostic role of TMB in non-small cell lung carcinoma,…”
Get full text

Loss of Cln5 causes altered neurogenesis in a mouse model of a childhood neurodegenerative disorder by Savchenko, Ekaterina, Singh, Yajuvinder, Konttinen, Henna, Lejavova, Katarina, Mediavilla Santos, Laura, Grubman, Alexandra, Kärkkäinen, Virve, Keksa-Goldsteine, Velta, Naumenko, Nikolay, Tavi, Pasi, White, Anthony R, Malm, Tarja, Koistinaho, Jari, Kanninen, Katja M

“…Neural stem/progenitor cells (NPCs) generate new neurons in the brain throughout an individual's lifetime in an intricate process called neurogenesis…”
Get full text

Loss of Cln5 leads to altered Gad1 expression and deficits in interneuron development in mice by Singh, Yajuvinder, Leinonen, Henri, Fazaludeen, Feroze, Jaronen, Merja, Guest, Debbie, Buckley, Noel, Byts, Nadiya, Oksa, Petra, Jalkanen, Kari, Iqbal, Imran, Huuskonen, Mikko, Savchenko, Ekaterina, Keksa-Goldsteine, Velta, Chew, Sweelin, Myllyharju, Johanna, Tanila, Heikki, Ooi, Lezanne, Koistinaho, Jari, Kanninen, Katja M, Malm, Tarja

“…Abstract The Finnish-variant late infantile neuronal ceroid lipofuscinosis, also known as CLN5 disease, is caused by mutations in the CLN5 gene. Cln5 is…”
Get full text