Search Results - "Singh, Warispreet"

Artificial cysteine-lipases with high activity and altered catalytic mechanism created by laboratory evolution by Cen, Yixin, Singh, Warispreet, Arkin, Mamatjan, Moody, Thomas S., Huang, Meilan, Zhou, Jiahai, Wu, Qi, Reetz, Manfred T.

“…Engineering artificial enzymes with high activity and catalytic mechanism different from naturally occurring enzymes is a challenge in protein design. For…”
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Structural basis of the membrane intramolecular transacylase reaction responsible for lyso-form lipoprotein synthesis by Olatunji, Samir, Bowen, Katherine, Huang, Chia-Ying, Weichert, Dietmar, Singh, Warispreet, Tikhonova, Irina G., Scanlan, Eoin M., Olieric, Vincent, Caffrey, Martin

“…Lipoproteins serve diverse functions in the bacterial cell and some are essential for survival. Some lipoproteins are adjuvants eliciting responses from the…”
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The complex structure of bile salt hydrolase from Lactobacillus salivarius reveals the structural basis of substrate specificity by Xu, Fuzhou, Hu, Xiao-Jian, Singh, Warispreet, Geng, Wenjing, Tikhonova, Irina G., Lin, Jun

“…The gut bacterial bile salt hydrolase (BSH) plays a critical role in host lipid metabolism and energy harvest. Therefore, BSH is a promising microbiome target…”
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Impact of the T296S mutation in P450 GcoA for aryl-O-demethylation: a QM/MM study by Santos, Sonia F G, Bommareddy, Rajesh Reddy, Black, Gary W, Singh, Warispreet

“…Lignin, a complex plant cell wall component, holds promise as a renewable aromatic carbon feedstock. p-Vanillin is a key product of lignin depolymerization and…”
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Effects of Mutations on Structure-Function Relationships of Matrix Metalloproteinase-1 by Singh, Warispreet, Fields, Gregg B, Christov, Christo Z, Karabencheva-Christova, Tatyana G

“…Matrix metalloproteinase-1 (MMP-1) is one of the most widely studied enzymes involved in collagen degradation. Mutations of specific residues in the MMP-1…”
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Remarkably Selective Binding, Behavior Modification, and Switchable Release of (Bipyridine)3Ru(II) vis-à-vis (Phenanthroline)3Ru(II) by Trimeric Cyclophanes in Water by Lin, Hong-Yu, Yao, Chao-Yi, Li, Jialu, Nimal Gunaratne, H. Q., Singh, Warispreet, Huang, Meilan, Anslyn, Eric V., de Silva, A. Prasanna

“…A recurring dream of molecular recognition is to create receptors that distinguish between closely related targets with sufficient accuracy, especially in…”
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Stereodivergent Protein Engineering of a Lipase To Access All Possible Stereoisomers of Chiral Esters with Two Stereocenters by Xu, Jian, Cen, Yixin, Singh, Warispreet, Fan, Jiajie, Wu, Lian, Lin, Xianfu, Zhou, Jiahai, Huang, Meilan, Reetz, Manfred T, Wu, Qi

“…Enzymatic stereodivergent synthesis to access all possible product stereoisomers bearing multiple stereocenters is relatively undeveloped, although enzymes are…”
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Thebaine is Selectively Demethylated by Thebaine 6‑O‑Demethylase and Codeine-3‑O‑demethylase at Distinct Binding Sites: A Computational Study by Singh, Warispreet, Hui, Chenggong, Li, Chun, Huang, Meilan

“…Two homologous 2-oxoglutarate-dependent (ODD) nonheme enzymes thebaine 6-O-demethylase (T6ODM) and codeine-3-O-demethylase (CODM), are involved in the morphine…”
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Reaction Mechanism of Histone Demethylation in αKG-dependent Non-Heme Iron Enzymes by Singh, Warispreet, Quinn, Derek, Moody, Thomas S, Huang, Meilan

“…Histone demethylases (KDMs) catalyze histone lysine demethylation, an important epigenetic process that controls gene expression in eukaryotes, and represent…”
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Substrate Conformation Regulates Aromatic C–H Vs C–F Bond Activation in Heme-Dependent Tyrosine Hydroxylase by Singh, Warispreet, Santos, Sonia F. G., Yadav, Shalini, Black, Gary W., Dubey, Kshatresh Dutta

“…A recently discovered heme-dependent enzyme tyrosine hydroxylase (TyrH) offers a green approach for functionalizing the high-strength C–H and C–F bonds in…”
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Regio- and stereoselectivity in the CYP450 BM3 -catalyzed hydroxylation of complex terpenoids: a QM/MM study by Hui, Chenggong, Singh, Warispreet, Quinn, Derek, Li, Chun, Moody, Thomas S, Huang, Meilan

“…The site-selective C-H oxidation of terpenoids by P450 attracts great attention because of their wide range of biological activities. However, the binding and…”
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Reaction Mechanism of Isopentenyl Phosphate Kinase: A QM/MM Study by McClory, James, Timson, David J, Singh, Warispreet, Zhang, Jian, Huang, Meilan

“…Isopentenyl phosphate kinase (IPK) catalyzes the Mg2+-ATP dependent phosphorylation reactions to produce isopentenyl diphosphate, an important precursor in the…”
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Computer-Informed Engineering: A New Class I Sesquiterpene Synthase JeSTS4 for the Synthesis of an Unusual C10‑(S)‑Bicyclogermacrene by Yan, Xiaoguang, Zhou, Jiahui, Ge, Jianjun, Li, Weiguo, Liang, Dongmei, Singh, Warispreet, Black, Gary, Nie, Shengxin, Liu, Jian, Sun, Meiqing, Qiao, Jianjun, Huang, Meilan

“…Terpene synthases (TPS) catalyze the cyclization of the acyclic prenyl diphosphate precursor and are responsible for the abundance of the natural product…”
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Mechanism of Phosphatidylglycerol Activation Catalyzed by Prolipoprotein Diacylglyceryl Transferase by Singh, Warispreet, Bilal, Munir, McClory, James, Dourado, Daniel, Quinn, Derek, Moody, Thomas S, Sutcliffe, Iain, Huang, Meilan

“…Lipoproteins are essential for bacterial survival. Bacterial lipoprotein biosynthesis is accomplished by sequential modification by three enzymes in the inner…”
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Taming Tris(bipyridine)ruthenium(II) and Its Reactions in Water by Capture/Release with Shape-Switchable Symmetry-Matched Cyclophanes by Yao, Chaoyi, Lin, Hongyu, Daly, Brian, Xu, Yikai, Singh, Warispreet, Gunaratne, H. Q. Nimal, Browne, Wesley R., Bell, Steven E. J., Nockemann, Peter, Huang, Meilan, Kavanagh, Paul, de Silva, A. Prasanna

“…Electron/proton transfers in water proceeding from ground/excited states are the elementary reactions of chemistry. These reactions of an iconic class of…”
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Rational design of a cyclohexanone dehydrogenase for enhanced α,β-desaturation and substrate specificity by Singh, Warispreet, Brown, Nicola L, McCue, Hannah V, Marriott, Sophie R, Wilson, Richard C, Perry, Justin, Turkenburg, Johan P, Dubey, Kshatresh D, Prior, Stephen H, Carnell, Andrew J, Taylor, Edward J, Black, Gary W

“…The selective α,β-desaturation of cyclic carbonyl compounds, which are found in the core of many steroid and bioactive molecules, using green chemistry is…”
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Conformational Dynamics, Ligand Binding and Effects of Mutations in NirE an S-Adenosyl-L-Methionine Dependent Methyltransferase by Singh, Warispreet, Karabencheva-Christova, Tatyana G., Black, Gary W., Ainsley, Jon, Dover, Lynn, Christov, Christo Z.

“…Heme d1, a vital tetrapyrrol involved in the denitrification processes is synthesized from its precursor molecule precorrin-2 in a chemical reaction catalysed…”
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Single-Site Mutation Induces Water-Mediated Promiscuity in Lignin Breaking Cytochrome P450 GcoA by Singh, Warispreet, Santos, Sónia F. G., James, Paul, Black, Gary W., Huang, Meilan, Dubey, Kshatresh Dutta

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Remarkably Selective Binding, Behavior Modification, and Switchable Release of (Bipyridine) 3 Ru(II) vis-à-vis (Phenanthroline) 3 Ru(II) by Trimeric Cyclophanes in Water by Lin, Hong-Yu, Yao, Chao-Yi, Li, Jialu, Nimal Gunaratne, H. Q., Singh, Warispreet, Huang, Meilan, Anslyn, Eric V., de Silva, A. Prasanna

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Single-Site Mutation Induces Water-Mediated Promiscuity in Lignin Breaking Cytochrome P450GcoA by Singh, Warispreet, Santos, Sónia F. G., James, Paul, Black, Gary W., Huang, Meilan, Dubey, Kshatresh Dutta

“…Cytochrome P450GcoA is an enzyme that catalyzes the guaiacol unit of lignin during the lignin breakdown via an aryl-O-demethylation reaction. This reaction is…”
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