Search Results - "Singh, Utpal K."

Interleukin‐17 regulates matrix metalloproteinase activity in human pulmonary tuberculosis by Singh, Shivani, Maniakis‐Grivas, George, Singh, Utpal K, Asher, Radha M, Mauri, Francesco, Elkington, Paul T, Friedland, Jon S

“…Tuberculosis (TB) is characterized by extensive pulmonary matrix breakdown. Interleukin‐17 (IL‐17) is key in host defence in TB but its role in TB‐driven…”
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Kinetics of liquid-phase hydrogenation reactions over supported metal catalysts — a review by Singh, Utpal K., Vannice, M.Albert

“…The kinetics of liquid-phase hydrogenation reactions have been reviewed with a special emphasis on α, β-unsaturated aldehydes as reactants. These reactions can…”
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Use of Modeling and Process Analytical Technologies in the Design of a Catalytic Amination Reaction: Understanding Oxygen Sensitivity at the Lab and Manufacturing Scales by Merritt, Jeremy M, Buser, Jonas Y, Campbell, Alison N, Fennell, Jared W, Kallman, Neil J, Koenig, Thomas M, Moursy, Hossam, Pietz, Mark A, Scully, Norma, Singh, Utpal K

“…A mechanistic approach was undertaken to understand the oxygen sensitivity of a Pd-catalyzed amination reaction used in the synthesis of an active…”
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Antimycobacterial Drugs Modulate Immunopathogenic Matrix Metalloproteinases in a Cellular Model of Pulmonary Tuberculosis by SINGH, Shivani, KUBLER, Andre, SINGH, Utpal K, SINGH, Ajay, GARDINER, Harriet, PRASAD, Rajniti, ELKINGTON, Paul T, FRIEDLAND, Jon S

“…Tuberculosis is characterized by extensive destruction and remodelling of the pulmonary extracellular matrix. Stromal cell-derived matrix metalloproteinases…”
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Liquid-Phase Citral Hydrogenation over SiO2-Supported Group VIII Metals by Singh, Utpal K, Vannice, M.Albert

“…Liquid-phase citral hydrogenation over SiO2-supported Group VIII metals at 300 K and 1 atm was studied in the absence of all transport limitations as verified…”
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Mechanistic Insights into the Pd(BINAP)-Catalyzed Amination of Aryl Bromides:  Kinetic Studies under Synthetically Relevant Conditions by Singh, Utpal K, Strieter, Eric R, Blackmond, Donna G, Buchwald, Stephen L

“…Kinetic studies using reaction calorimetry were carried out under synthetically relevant conditions to study the mechanism of the amination of bromobenzene…”
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Telescoped Approach to Aryl Hydroxymethylation in the Synthesis of a Key Pharmaceutical Intermediate by Slattery, Catherine N, Deasy, Rebecca E, Maguire, Anita R, Kopach, Michael E, Singh, Utpal K, Argentine, Mark D, Trankle, William G, Scherer, Roger Brian, Moynihan, Humphrey

“…An efficient synthetic approach leading to introduction of the hydroxymethyl group to an aryl moiety via combination of the Bouveault formylation and hydride…”
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Practical Asymmetric Synthesis of an Edivoxetine·HCl Intermediate via an Efficient Diazotization Process by Kopach, Michael E, Heath, Perry C, Scherer, Roger B, Pietz, Mark A, Astleford, Bret A, McCauley, Mary Kay, Singh, Utpal K, Wong, Sze Wing, Coppert, David M, Kerr, Mark S, Houghton, Peter G, Rhodes, Gary A, Tharp, Gregg A

“…A convergent synthesis of (S)-(4-benzylmorpholin-2-yl)­(morpholino)­methanone methanesulfonate (1), a key regulatory starting material for edivoxetine·HCl, was…”
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Deactivation of Heterogeneous Hydrogenation Catalysts by Alcoholic Solvents by Singh, Utpal K, Krska, Shane W, Sun, Yongkui

“…Hydrogenations using supported metal catalysts are ubiquitous in organic chemistry; yet often times there is a lack of knowledge of key subtle mechanistic…”
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Practical Synthesis of Chiral 2-Morpholine: (4-Benzylmorpholin-2-(S)-yl)-(tetrahydropyran-4-yl)methanone Mesylate, a Useful Pharmaceutical Intermediate by Kopach, Michael E, Singh, Utpal K, Kobierski, Michael E, Trankle, William G, Murray, Michael M, Pietz, Mark A, Forst, Mindy B, Stephenson, Gregory A, Mancuso, Vincent, Giard, Thierry, Vanmarsenille, Michel, DeFrance, Thierry

“…A commercial synthesis was developed for the production of (4-benzylmorpholin-2-(S)-yl)-(tetrahydropyran-4-yl)methanone mesylate, 1a, a key starting material…”
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Identifying Scale Sensitivity for API Crystallizations from Desupersaturation Measurements by Singh, Utpal K, Pietz, Mark A, Kopach, Michael E

“…The present report details a methodology for discriminating between mass transfer- and surface integration-controlled crystallizations. Initial…”
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Influence of metal–support interactions on the kinetics of liquid-phase citral hydrogenation by Singh, Utpal K., Vannice, M.Albert

“…The kinetics of liquid-phase hydrogenation of citral (3,7-dimethyl-2,6-octadienal) on Pt/TiO 2 catalysts were studied between 298–423 K and 7–21 atm H 2 and…”
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Stem Cell Through Present and Future by Sharma, Vijay K., Singh, Utpal K., Prasad, Rajniti, Fletcher, Sophie

“…Stem cell transplantation (SCT) has the potential to transform the lives of children with a wide variety of genetic diseases, ranging from inherent defects of…”
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Kinetic and thermodynamic analysis of liquid-phase benzene hydrogenation by Singh, Utpal K., Vannice, M. Albert

“…Liquid‐phase benzene hydrogenation on Pd/η‐Al2O3 catalysts was studied between 358 and 488 K and over an H2 pressure range of 7 to 54 atm. Kinetic data were…”
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Incorporation and Characterization of a Mixing Elbow on the Pilot Plant Scale for a Mixing Sensitive Crystallization of an API by Singh, Utpal K, Spencer, Glenn, Osifchin, Rich, Tabora, Jose, Davidson, Omar A, Orella, Charles J

“…A mixing elbow was, for the first time, characterized on the pilot plant scale using the Fourth Bourne Reaction to obtain a correlation for mixing time using…”
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Liquid-Phase Hydrogenation of Citral over Pt/SiO2 Catalysts: I. Temperature Effects on Activity and Selectivity by Singh, Utpal K., Albert Vannice, M.

“…Liquid-phase hydrogenation of citral (3,7-dimethyl-2,6-octadienal) over Pt/SiO2 catalysts was studied in the temperature and pressure ranges 298–423 K and 7–21…”
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Molecular Epidemiology of Extended-Spectrum β-Lactamase–Producing Escherichia coli Pathotypes in Diarrheal Children from Low Socioeconomic Status Communities in Bihar, India: Emergence of the CTX-M Type by Mandal, Abhishek, Sengupta, Abhishek, Kumar, Ajay, Singh, Utpal K, Jaiswal, Anil K, Das, Pradeep, Das, Sushmita

“…Background: Childhood diarrheal diseases remain highly endemic in India, but the emergence of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli…”
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Erratum to “Kinetics of liquid-phase hydrogenation reactions over supported metal catalyst—a review” [Appl. Catal. A: Gen. 213 (2001) 1–24] by Singh, Utpal K., Vannice, M.Albert

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Association of possible osteopetrosis with acute myeloid leukaemia in a child by Prasad, Rajniti, Jaiswal, B P, Mishra, O P, Singh, Utpal Kant

“…Osteopetrosis is a rare disease characterised by an increase in bone mass, skeletal malformations and bone marrow failure due to defective bone resorption. We…”
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Liquid-Phase Hydrogenation of Citral over Pt/SiO2 Catalysts: II. Hydrogenation of Reaction Intermediate Compounds by Singh, Utpal K., Sysak, Matthew N., Vannice, M.Albert

“…Liquid-phase hydrogenation of the four principal reaction intermediates formed during citral hydrogenation, i.e., nerol, geraniol, citronellal, and…”
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