Search Results - "Singh, Sunanda"

Overcoming Acquired Drug Resistance to Cancer Therapies through Targeted STAT3 Inhibition by Singh, Sunanda, Gomez, Hector J, Thakkar, Shreya, Singh, Samara P, Parihar, Ashutosh S

“…Anti-neoplastic agents for cancer treatment utilize many different mechanisms of action and, when combined, can result in potent inhibition of cancer growth…”
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A Broad-Based Characterization of a Cell-Penetrating, Single Domain Camelid Bi-Specific Antibody Monomer That Targets STAT3 and KRAS Dependent Cancers by Singh, Sunanda, Murillo, Genoveva, Richner, Justin, Singh, Samara P., Berleth, Erica, Kumar, Vijay, Mehta, Rajendra, Ramiya, Vijay, Parihar, Ashutosh S.

“…STAT3 and KRAS regulate cell proliferation, survival, apoptosis, cell migration, and angiogenesis. Aberrant expression of STAT3 and mutant active forms of KRAS…”
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STAT3-Specific Single Domain Nanobody Inhibits Expansion of Pathogenic Th17 Responses and Suppresses Uveitis in Mice by Mbanefo, Evaristus C, Yan, Ming, Kang, Minkyung, Alhakeem, Sahar A, Jittayasothorn, Yingyos, Yu, Cheng-Rong, Parihar, Ashutosh, Singh, Sunanda, Egwuagu, Charles E

“…STAT3 activates transcription of genes that regulate cell growth, differentiation, and survival of mammalian cells. Genetic deletion of in T cells has been…”
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A Camelid-Derived STAT-Specific Nanobody Inhibits Neuroinflammation and Ameliorates Experimental Autoimmune Encephalomyelitis (EAE) by Mbanefo, Evaristus C, Seifert, Allison, Yadav, Manoj Kumar, Yu, Cheng-Rong, Nagarajan, Vijayaraj, Parihar, Ashutosh, Singh, Sunanda, Egwuagu, Charles E

“…Proinflammatory T-lymphocytes recruited into the brain and spinal cord mediate multiple sclerosis (MS) and currently there is no cure for MS. IFN-γ-producing…”
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Suppression of Breast Cancer Cell Proliferation by Selective Single-Domain Antibody for Intracellular STAT3 by Singh, Sunanda, Murillo, Genoveva, Chen, Dong, Parihar, Ashutosh S, Mehta, Rajendra G

“…Background: The serendipitous discovery of heavy-chain antibodies devoid of light chains in camelids and the subsequent development of VHHs (variable region of…”
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Relative levels of RNA polII subunits differentially affect starvation response in budding yeast by Singh, Sunanda R., Pillai, Beena, Balakrishnan, Bindu, Naorem, Aruna, Sadhale, Parag P.

“…The Rpb4/7 subcomplex of RNA polymerase II in Saccharomyces cerevisiae is known to play an important role in stress response and stress survival. These two…”
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Domainal organization of the lower eukaryotic homologs of the yeast RNA polymerase II core subunit Rpb7 reflects functional conservation by Singh, S.R, Rekha, N, Pillai, B, Singh, V, Naorem, A, Sampath, V, Srinivasan, N, Sadhale, P.P

“…The subcomplex of Rpb4 and Rpb7 subunits of RNA pol II in Saccharomyces cerevisiae is known to be an important determinant of transcription under a variety of…”
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Stroma is critical for preventing or permitting immunological destruction of antigenic cancer cells by SUNANDA SINGH, ROSS, S. R, ACENA, M, ROWLEY, D. A, SCHREIBER, H

“…Inoculated immunogenic cancer cells after initial growth are potentially rejected by specific host immunity; however, the outcome of the interaction between…”
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Abstract 1544: Cell penetrating single domain antibody (sdAb) SBT-100 binds KRAS and inhibits growth of human cancers with KRAS activating mutations by Singh, Sunanda, Murillo, Genoveva, Singh, Avani, Singh, Samara, Parihar, Meenakshi, Singh, Anjali, Mehta, Rajendra, Parihar, Ashutosh

“…Abstract Background: Despite nearly fourth years of research, scientists have failed to develop a clinically viable therapy against KRAS, one of the deadliest…”
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Abstract 5436: Novel single-domain antibody (sdAb), SBT-100, localizes in the cytoplasm to inhibit IL-6 mediated P-STAT3 nuclear translocation in cancer cells by Singh, Sunanda, Murillo, Genoveva, Singh, Avani, Singh, Samara, Parihar, Meenakshi, Mehta, Rajendra, Singh, Anjali, Parihar, Ashutosh

“…Abstract BACKGROUND: Interleukin-6 (IL-6) is a multifunctional cytokine that is involved in immune defense and plays an important role in biologic activities…”
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Single domain antibody (SBT-100) crosses the blood brain barrier (BBB) and inhibits human glioblastoma by selectively targeting KRAS and P-STAT3 by Singh, Sunanda, Murillo, Genoveva, Singh, Avani, Singh, Samara, Parihar, Meenakshi S, Singh, Anjali H, Mehta, Rajendra, Parihar, Ashutosh S

“…Abstract only e13547 Background: Glioblastoma is difficult to treat malignancy that has a high incidence of KRAS mutations ( > 90%) and hyper-expression of…”
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Effect of KRAS and P-STAT3 inhibition by SBT-100 on gemcitabine and pancreatic cancer growth in vivo by Singh, Sunanda, Murillo, Genoveva, Singh, Avani, Singh, Samara, Parihar, Meenakshi S, Singh, Anjali H, Mehta, Rajendra, Parihar, Ashutosh S

“…Abstract only e15727 Background: Over 90% of pancreatic cancers have KRAS mutations and hyper-expression of P-STAT3 oncoproteins, which if specifically…”
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A novel single domain antibody (sdAb) SBT-100 targeting intracellular STAT3 to inhibit major subtypes of human breast cancer by Singh, Sunanda, Murillo, Genoveva, Mehta, Rajendra, Chen, Dong, Singh, Avani, Singh, Samara, Singh, Anjali, Parihar, Ashutosh S

“…Abstract only…”
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A novel single domain antibody (sdAb) SBT-100 to target intracellular STAT3 to affect growth and regression of human triple negative breast cancer (TNBC) cells by Singh, Sunanda, Murillo, Genoveva, Mehta, Rajendra, Chen, Dong, Singh, Avani, Singh, Samara, Singh, Anjali, Parihar, Ashutosh S

“…Abstract only…”
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Abstract 4699: Single domain antibody (sdAb) localizes in cancer cells to inhibit signal transducer and activator of transcription 3 (STAT3) resulting in therapeutic inhibition of multiple cancers by Singh, Sunanda, Murillo, Genoveva, Rom, Amanda, Singh, Avani, Singh, Samara, Parihar, Meenakshi, Chen, Dong, Mehta, Rajendra, Baker, Robert, Singh, Anjali, Parihar, Ashutosh S.

“…Abstract STAT3 is involved in the pathogenesis of many malignancies, so we developed an anti-STAT3 VHH (variable region of the heavy chain), SBT-100, that…”
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CD4-positive and B lymphocytes in transplantation immunity. I. Promotion of tumor allograft rejection through elimination of CD4-positive lymphocytes by Koeppen, H K, Singh, S, Stauss, H J, Park, B H, Rowley, D A, Schreiber, H

“…The elimination of CD4+ cells by anti-CD4 antibody caused regression of a malignant solid tumor allograft that does not lose a cytotoxic T lymphocyte-defined…”
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Current Surgical Therapy for Quadriplegia: Functional Electrical Stimulation by Greenwald, Daniel, Keith, Michael W, Aguiar, Joseph, Singh, Sunanda

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Tumor stroma and the immunological destruction of solid cancers by SINGH, SUNANDA

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Avoiding Constriction Bands During Breast Augmentation by Singh, Sunanda, Baker, James L.

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Genetically engineered vaccines. Comparison of active versus passive immunotherapy against solid tumors by Koeppen, H, Singh, S, Schreiber, H

“…Late tumor bearers (LTB), that is, mice that had tumors 3 weeks or longer, can have a selective immune dysfunction and fail to respond to target antigens…”
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