Search Results - "Singh, Sumeet K."

The 20S as a stand-alone proteasome in cells can degrade the ubiquitin tag by Sahu, Indrajit, Mali, Sachitanand M., Sulkshane, Prasad, Xu, Cong, Rozenberg, Andrey, Morag, Roni, Sahoo, Manisha Priyadarsini, Singh, Sumeet K., Ding, Zhanyu, Wang, Yifan, Day, Sharleen, Cong, Yao, Kleifeld, Oded, Brik, Ashraf, Glickman, Michael H.

“…The proteasome, the primary protease for ubiquitin-dependent proteolysis in eukaryotes, is usually found as a mixture of 30S, 26S, and 20S complexes. These…”
Get full text

Affinity Maturation of Macrocyclic Peptide Modulators of Lys48‐Linked Diubiquitin by a Twofold Strategy by Huang, Yichao, Nawatha, Mickal, Livneh, Ido, Rogers, Joseph M., Sun, Hao, Singh, Sumeet K., Ciechanover, Aaron, Brik, Ashraf, Suga, Hiroaki

“…Messenger RNA display of peptides containing non‐proteinogenic amino acids, referred to as RaPID system, has become one of the leading methods to express…”
Get full text

Ubiquitin Signaling: Chemistry Comes to the Rescue by Mali, Sachitanand M, Singh, Sumeet K, Eid, Emad, Brik, Ashraf

“…Posttranslational modification of proteins by ubiquitin (Ub), i.e., ubiquit­ination, mediates a variety of cellular processes, including protein homeostasis,…”
Get full text

Peptide and protein chemistry approaches to study the tumor suppressor protein p53 by Chatterjee, Champak, Singh, Sumeet K

“…The tumor suppressor and master gene regulator protein p53 has been the subject of intense investigation for several decades due to its mutation in about half…”
Get more information

The semisynthesis of site-specifically modified histones and histone-based probes of chromatin-modifying enzymes by Currie, Madeline F., Singh, Sumeet K., Ji, Meihuan, Chatterjee, Champak

“…•Histone PTMs play an important role in regulating gene transcription.•Semisynthetic histones with defined PTMs are key to investigating the histone…”
Get full text

Diverse fate of ubiquitin chain moieties: The proximal is degraded with the target, and the distal protects the proximal from removal and recycles by Sun, Hao, Mali, Sachitanand M., Singh, Sumeet K., Meledin, Roman, Brik, Ashraf, Kwon, Yong Tae, Kravtsova-Ivantsiv, Yelena, Bercovich, Beatrice, Ciechanover, Aaron

“…One of the enigmas in the ubiquitin (Ub) field is the requirement for a poly-Ub chain as a proteasomal targeting signal. The canonical chain appears to be…”
Get full text

Protein ubiquitination via dehydroalanine: development and insights into the diastereoselective 1,4-addition step by Meledin, Roman, Mali, Sachitanand M, Singh, Sumeet K, Brik, Ashraf

“…We report a strategy for site-specific protein ubiquitination using dehydroalanine (Dha) chemistry for the preparation of ubiquitin conjugates bearing a very…”
Get more information

Total chemical synthesis of sumoylated histone H4 reveals negative biochemical crosstalk with histone ubiquitylation by Singh, Sumeet K, Reyna, Andres, Xie, Xiaowen, Mao, Haibin, Ji, Meihuan, Zheng, Ning, Hsu, Peter L, Chatterjee, Champak

“…An efficient total chemical synthesis of site-specifically sumoylated histone H4 was undertaken to generate homogenously modified mononucleosomes. These were…”
Get more information

Betaine alleviates doxorubicin‐induced nephrotoxicity by preventing oxidative insults, inflammation, and fibrosis through the modulation of Nrf2/HO−1/NLRP3 and TGF‐β expression by Patel, Dhaneshvaree, Yadav, Poonam, Singh, Sumeet K., Tanwar, Sampat S., Sehrawat, Abhishek, Khurana, Amit, Bhatti, Jasvinder S., Navik, Umashanker

“…Doxorubicin (Dox) is an anthracycline antibiotic used to treat various cancers and shows severe toxicity in multiple organ systems, including kidneys. Evidence…”
Get full text

Synthetic Uncleavable Ubiquitinated Proteins Dissect Proteasome Deubiquitination and Degradation, and Highlight Distinctive Fate of Tetraubiquitin by Singh, Sumeet K, Sahu, Indrajit, Mali, Sachitanand M, Hemantha, Hosahalli P, Kleifeld, Oded, Glickman, Michael H, Brik, Ashraf

“…Various hypotheses have been proposed regarding how chain length, linkage type, position on substrate, and susceptibility to deubiquitinases (DUBs) affect…”
Get full text

Total Chemical Synthesis of ISGylated-Ubiquitin Hybrid Chain Assisted by Acetamidomethyl Derivatives with Dual Functions by Eid, Emad, Boross, Gábor N, Sun, Hao, Msallam, Muna, Singh, Sumeet K, Brik, Ashraf

“…Interferon-stimulated gene 15 (ISG15) is a member of the ubiquitin-like modifiers (ULM) family, which adopts a β-grasp fold domain(s) similar to ubiquitin (Ub)…”
Get full text

pH sensitive coiled coils: a strategy for enhanced liposomal drug delivery by Reja, Rahi M, Khan, Mohsina, Singh, Sumeet K, Misra, Rajkumar, Shiras, Anjali, Gopi, Hosahudya N

“…Stimuli responsive controlled release from liposome based vesicles is a promising strategy for the site specific delivery of drugs. Herein, we report the…”
Get more information

γ-Amino acid mutated α-coiled coils as mild thermal triggers for liposome delivery by Jadhav, Sandip V, Singh, Sumeet K, Reja, Rahi M, Gopi, Hosahudya N

“…The stability and compatibility of designed coiled coil peptides towards the selective incorporation of γ(4)-amino acids at the hydrophobic positions of the…”
Get more information

Efficient Access to Enantiopure γ4-Amino Acids with Proteinogenic Side-Chains and Structural Investigation of γ4-Asn and γ4-Ser in Hybrid Peptide Helices by Jadhav, Sandip V., Misra, Rajkumar, Singh, Sumeet K., Gopi, Hosahudya N.

“…Hybrid peptides composed of α‐ and β‐amino acids have recently emerged as new class of peptide foldamers. Comparatively, γ‐ and hybrid γ‐peptides composed of…”
Get full text

Chronic Traumatic Aneurysm of the Left Main Coronary Artery Causing Myocardial Infarction by Ngaage, Dumbor L., Singh, Sumeet K., Bresnahan, John F., Wright, Scott R., McGregor, Christopher G.A.

Get full text

Chemical Synthesis of Ubiquitin Chains by Hemantha, Hosahalli P, Bondalapati, Somasekhar, Singh, Sumeet K, Brik, Ashraf

“…Chemical synthesis of complex biomolecules such as proteins is a challenging adventure, yet rewarding in driving various biochemical and biophysical research…”
Get more information

Efficient Access to Enantiopure [gamma]4-Amino Acids with Proteinogenic Side-Chains and Structural Investigation of [gamma]4-Asn and [gamma]4-Ser in Hybrid Peptide Helices by Jadhav, Sandip V, Misra, Rajkumar, Singh, Sumeet K, Gopi, Hosahudya N

“…Hybrid peptides composed of [alpha]- and [beta]-amino acids have recently emerged as new class of peptide foldamers. Comparatively, [gamma]- and hybrid…”
Get full text

Efficient Access to Enantiopure γ 4 ‐Amino Acids with Proteinogenic Side‐Chains and Structural Investigation of γ 4 ‐Asn and γ 4 ‐Ser in Hybrid Peptide Helices by Jadhav, Sandip V., Misra, Rajkumar, Singh, Sumeet K., Gopi, Hosahudya N.

“…Abstract Hybrid peptides composed of α‐ and β‐amino acids have recently emerged as new class of peptide foldamers. Comparatively, γ‐ and hybrid γ‐peptides…”
Get full text

Efficient Access to Enantiopure [gamma] super(4)-Amino Acids with Proteinogenic Side-Chains and Structural Investigation of [gamma] super(4)-Asn and [gamma] super(4)-Ser in Hybrid Peptide Helices by Jadhav, Sandip V, Misra, Rajkumar, Singh, Sumeet K, Gopi, Hosahudya N

“…Hybrid peptides composed of [alpha]- and [beta]-amino acids have recently emerged as new class of peptide foldamers. Comparatively, [gamma]- and hybrid…”
Get full text

Project Go! Helping veterans attend their mental health appointments by Singh, Sumeet K., Brosnan, Tanya, Farmer, Aaron, Oskotsky, Tomiko, Hee, Patti, Bradley, Christa, Hirahoka, Lucinda

Get full text