Search Results - "Singh, Shashank K."

Divergent Signaling Pathways May Lead to Convergence in Cancer Therapy - A Review by Qayum, Arem, Shah, Syed Mohmad, Singh, Shashank K

“…Cancer is a chaos of uncontrolled cell proliferation that has consistently invented new circuitry programs to operate inside the cell machinery. Globally,…”
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Synergistic combination of gemcitabine and dietary molecule induces apoptosis in pancreatic cancer cells and down regulates PKM2 expression by Pandita, Archana, Kumar, Bhupender, Manvati, Siddharth, Vaishnavi, Samantha, Singh, Shashank K, Bamezai, Rameshwar N K

“…Gemcitabine, an effective agent in treatment of cancer of pancreas, has undergone failures in many instances after multiple cycles of therapy due to emergence…”
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Anticancer Activity of Cordia dichotoma against a Panel of Human Cancer Cell Lines and Their Phytochemical Profiling via HPLC and GCMS by Raina, Shilpa, Sharma, Vikas, Sheikh, Zahid Nabi, Kour, Navneet, Singh, Shashank K, Zari, Ali, Zari, Talal A, Alharby, Hesham F, Hakeem, Khalid Rehman

“…The current study was conducted to examine the in vitro anticancer potential of (bark, leaves, pulp and seed). The plant material was collected from UT of J&K…”
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Vitamin E TPGS based palatable, oxidatively and physically stable emulsion of microalgae DHA oil for infants, children and food fortification by Singh, Harmanpreet, Singh, Jasvinder, Singh, Shashank K., Singh, Narpinder, Paul, Surinder, Sohal, Harminder Singh, Gupta, Umesh, Jain, Subheet Kumar

“…Clinically, Docosahexaenoic acid (DHA) has been implicated for the prevention of cognitive disorders and is considered as a vital component for normal brain…”
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Discovery of a Secalonic Acid Derivative from Aspergillus aculeatus, an Endophyte of Rosa damascena Mill., Triggers Apoptosis in MDA-MB-231 Triple Negative Breast Cancer Cells by Farooq, Sadaqat, Qayum, Arem, Nalli, Yedukondalu, Lauro, Gianluigi, Chini, Maria Giovanna, Bifulco, Giuseppe, Chaubey, Asha, Singh, Shashank K, Riyaz-Ul-Hassan, Syed, Ali, Asif

“…A new secalonic acid derivative, F-7 (1), was isolated from the endophytic Aspergillus aculeatus MBT 102, associated with Rosa damascena. The planar structure…”
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Development and evaluation of paclitaxel loaded PLGA:poloxamer blend nanoparticles for cancer chemotherapy by Gupta, Prem N., Jain, Sharad, Nehate, Chetan, Alam, Noor, Khare, Vaibhav, Dubey, Ravindra Dhar, Saneja, Ankit, Kour, Smit, Singh, Shashank K.

“…This investigation described the development of novel PLGA:poloxamer blend nanoparticles for intravenous administration of paclitaxel in order to limit the…”
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Carbohydrate Modifications of Neoandrographolide for Improved Reactive Oxygen Species-Mediated Apoptosis through Mitochondrial Pathway in Colon Cancer by Sharma, Venu, Qayum, Arem, Kaul, Sanjana, Singh, Ajeet, Kapoor, Kamal K, Mukherjee, Debaraj, Singh, Shashank K, Dhar, Manoj K

“…Modifications at the carbohydrate moiety of neoandrographolide, isolated from the medicinal plant Andrographis paniculata, result in more potent and less toxic…”
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Tandem MS-Based Metabolite Profiling of 19,20-Epoxycytochalasin C Reveals the Importance of a Hydroxy Group at the C7 Position for Biological Activity by Kushwaha, Manoj, Qayum, Arem, Jain, Shreyans K, Singh, Jasvinder, Srivastava, Amit Kumar, Srivastava, Shubham, Sharma, Nisha, Abrol, Vidushi, Malik, Ruchi, Singh, Shashank K, Vishwakarma, Ram A, Jaglan, Sundeep

“…Seven cytochalasins, 19,20-epoxycytochalasin N, cytochalasin P1, deacetyl 19,20-epoxycytochalasin C, 19,20-epoxycytochalasin D, 19,20-epoxycytochalasin C,…”
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Oncogenic BRAF, endoplasmic reticulum stress, and autophagy: Crosstalk and therapeutic targets in cutaneous melanoma by Rather, Rafiq A, Bhagat, Madhulika, Singh, Shashank K

“…BRAF is a member of the RAF family of serine/threonine-specific protein kinases. Oncogenic BRAF, in particular, BRAF V600E, can disturb the normal protein…”
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In vitro cytotoxic potential of Polyalthia longifolia on human cancer cell lines and induction of apoptosis through mitochondrial-dependent pathway in HL-60 cells by Verma, Monika, Singh, Shashank K., Bhushan, Shashi, Sharma, V.K., Datt, Prabhu, Kapahi, B.K., Saxena, A.K.

“…Polyalthia longifolia is a lofty evergreen tree found in India and Sri Lanka. We are reporting first time the anticancer potential of P. longifolia leaves…”
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Chitosan Engineered PAMAM Dendrimers as Nanoconstructs for the Enhanced Anti-Cancer Potential and Improved In vivo Brain Pharmacokinetics of Temozolomide by Sharma, Ashok Kumar, Gupta, Lokesh, Sahu, Hitesh, Qayum, Arem, Singh, Shashank K., Nakhate, Kartik T., Ajazuddin, Gupta, Umesh

“…Purpose To establish a platform for the possibility of effective and safe delivery of Temozolomide (TMZ) to brain via surface engineered (polyamidoamine) PAMAM…”
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NF-κB down-regulation and PARP cleavage by novel 3-α-butyryloxy-β-boswellic acid results in cancer cell specific apoptosis and in vivo tumor regression by Qurishi, Yasrib, Hamid, Abid, Sharma, Parduman R, Wani, Zahoor A, Mondhe, Dilip M, Singh, Shashank K, Zargar, Mohmmad A, Andotra, Samar S, Shah, Bhahwal A, Taneja, Subhash C, Saxena, Ajit K

“…The present study relates to the induction of apoptosis thereof cytotoxicity and anti-cancer activity displayed by semi-synthetic analog of Boswellic acid i.e…”
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Repurposing FDA approved drugs against Sterol C-24 methyltransferase of Leishmania donovani: A dual in silico and in vitro approach by Kumari, Diksha, Jamwal, Vishwani, Singh, Ajeet, Singh, Shashank K., Mujwar, Somdutt, Ansari, Md. Yousuf, Singh, Kuljit

“…•Leishmaniasis is a disease caused by the parasite Leishmania donovani affecting populations belonging to developing countries.•Drug repurposing is a trending…”
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6-Nitro-2-(3-hydroxypropyl)-1H-benz[de]isoquinoline-1,3-dione, a potent antitumor agent, induces cell cycle arrest and apoptosis by Mukherjee, Asama, Dutta, Sushanta, Shanmugavel, Muthiah, Mondhe, Dilip M, Sharma, Parduman R, Singh, Shashank K, Saxena, Ajit K, Sanyal, Utpal

“…Anticancer activities of several substituted naphthalimides (1H-benz[de]isoquinoline-1,3-diones) are well documented. Some of them have undergone Phase I-II…”
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The Role of Endocannabinoid System in Neuroprotection: Molecular Targets and Therapeutic Opportunities by Thapa, Sonia, Singh, Shashank K.

“…Objective: To describe the endocannabinoid system, cannabinoid receptors, its agonism/antagonism in neurodegenerative disorders. Introduction: The…”
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Development and evaluation of folate functionalized albumin nanoparticles for targeted delivery of gemcitabine by Dubey, Ravindra Dhar, Alam, Noor, Saneja, Ankit, Khare, Vaibhav, Kumar, Ashok, Vaidh, Shagun, Mahajan, Girish, Sharma, Parduman R., Singh, Shashank K., Mondhe, Dilip M., Gupta, Prem N.

“…[Display omitted] Gemcitabine is one of the most potent anticancer agents acting on a wide range of solid tumors, however, its use is limited by short half…”
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Crystal Structure, quantum chemical analysis and apoptotic propensity of diaryl substituted α-aminophosphonates as selected C P bonded systems by Raheem, Shabnam, Jan, Tabee, Qayum, Arem, Yadav, Oval, Mustafa, Mohd, Ansari, Azaj, Mustafa Peerzada, Ghulam, Singh, Shashank K, Ahmad Rizvi, Masood

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Raloxifene, a SERM targets PD-L1: an in-silico study by Chopra, Chirag, Yodun, Tenzen, Singh, Harpreet, Singh, Bhupender, Singh, Shashank K, Goutam, Umesh

“…OBJECTIVESImmunotherapeutic interventions in cancer have been considerably successful and widely accepted for cancer treatment, but are costly and cannot be…”
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A novel carissic acid from fruits of Carissa carandas induced apoptotic cell death in A-549 cells following the activation of caspases by Kour, Navneet, Qayum, Arem, Lone, Bashir A., Singh, Shashank K, Sharma, Vikas, Gupta, Prasoon

“…This study was designed to identify cytotoxic compounds from Carissa carandas extract. The cytotoxic activity of extract and fractions were assessed against…”
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Biodegradable nano-architectural PEGylated approach for the improved stability and anticancer efficacy of bendamustine by Khan, Iliyas, Gothwal, Avinash, Sharma, Ashok Kumar, Qayum, Arem, Singh, Shashank K., Gupta, Umesh

“…Bendamustine is a drug of choice for the treatment of several cancers including non- Hodgkin lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL). The…”
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