Search Results - "Singh, Shankar Mohan"

Structural Characterization of the Human Androgen Receptor Ligand-binding Domain Complexed with EM5744, a Rationally Designed Steroidal Ligand Bearing a Bulky Chain Directed toward Helix 12 by Cantin, Line, Faucher, Frédérick, Couture, Jean-François, de Jésus-Tran, Karine Pereira, Legrand, Pierre, Ciobanu, Liviu C., Fréchette, Yvon, Labrecque, Richard, Singh, Shankar Mohan, Labrie, Fernand, Breton, Rock

“…Antiandrogens are commonly used to treat androgen-dependent disorders. The currently used drugs unfortunately possess very weak affinity for the human AR…”
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EM-652 (SCH 57068), a third generation SERM acting as pure antiestrogen in the mammary gland and endometrium by Labrie, Fernand, Labrie, Claude, Bélanger, Alain, Simard, Jacques, Gauthier, Sylvain, Luu-The, Van, Mérand, Yves, Giguere, Vincent, Candas, Bernard, Luo, Shouqi, Martel, Céline, Singh, Shankar Mohan, Fournier, Marc, Coquet, Agnès, Richard, Virgile, Charbonneau, Ronald, Charpenet, Gilles, Tremblay, André, Tremblay, Gilles, Cusan, Lionel, Veilleux, Raymonde

“…Breast cancer is the most frequent cancer in women while it is the second cause of cancer death. Estrogens are well recognized to play the predominant role in…”
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Comparison of in vitro effects of the pure antiandrogens OH-flutamide, casodex, and nilutamide on androgen-sensitive parameters by Simard, Jacques, Singh, Shankar Mohan, Labrie, Fernand

“…Objectives. A combination of flutamide (Eulexin) or nilutamide (Anandron) with a luteinizing hormone-releasing hormone (LHRH) agonist or orchiectomy is the…”
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Antifungal susceptibility of clinical and environmental Cryptococcus neoformans and Cryptococcus gattii isolates in Jabalpur, a city of Madhya Pradesh in Central India by Gutch, Ruchi Sethi, Nawange, Shesh Rao, Singh, Shankar Mohan, Yadu, Ruchika, Tiwari, Aditi, Gumasta, Richa, Kavishwar, Arvind

“…In this study, we present antifungal susceptibility data of clinical and environmental isolates of Central Indian Cryptococcus neoformans (Serotype A, n = 8…”
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Daily dosing with flutamide or casodex exerts maximal antiandrogenic activity by Luo, Shouqi, Martel, Céline, Chen, Cailin, Labrie, Claude, Cands, Bernard, Singh, Shankar Mohan, Labrie, Fernand

“…Because the large increase in luteinizing hormone secretion induced by flutamide in the intact rat is not found in men, we have used castrated rats and mice…”
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Long‐term inhibitory effect of the orally active and pure antiestrogen EM‐800 on the growth of human breast cancer xenografts in nude mice by Couillard, Steeve, Labrie, Claude, Gauthier, Sylvain, Merand, Yves, Singh, Shankar Mohan, Candas, Bernard, Labrie, Fernand

“…The antiproliferative effect of the new antiestrogen EM‐800 has been studied during 40 weeks of treatment on human breast carcinoma ZR‐75–1 xenografts in…”
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Comparison of in vitro effects of the pure antiandrogens OH-flutamide, casodex, and nilutamide on androgen-sensitive parameters. Commentary. Authors' reply by SIMARD, J, SHANKAR MOHAN SINGH, LABRIE, F, SIMARD, J, CANDAS, B, SCHELLHAMMER, P. F

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