Search Results - "Singh, Samara"

Combined MEK and STAT3 Inhibition Uncovers Stromal Plasticity by Enriching for Cancer-Associated Fibroblasts With Mesenchymal Stem Cell-Like Features to Overcome Immunotherapy Resistance in Pancreatic Cancer by Datta, Jashodeep, Dai, Xizi, Bianchi, Anna, De Castro Silva, Iago, Mehra, Siddharth, Garrido, Vanessa T., Lamichhane, Purushottam, Singh, Samara P., Zhou, Zhiqun, Dosch, Austin R., Messaggio, Fanuel, Ban, Yuguang, Umland, Oliver, Hosein, Peter J., Nagathihalli, Nagaraj S., Merchant, Nipun B.

“…We have shown that reciprocally activated rat sarcoma (RAS)/mitogen-activated protein kinase/extracellular signal-regulated kinase (MEK) and Janus…”
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Overcoming Acquired Drug Resistance to Cancer Therapies through Targeted STAT3 Inhibition by Singh, Sunanda, Gomez, Hector J, Thakkar, Shreya, Singh, Samara P, Parihar, Ashutosh S

“…Anti-neoplastic agents for cancer treatment utilize many different mechanisms of action and, when combined, can result in potent inhibition of cancer growth…”
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Emerging Role of CREB in Epithelial to Mesenchymal Plasticity of Pancreatic Cancer by Mehra, Siddharth, Singh, Samara, Nagathihalli, Nagaraj

“…Pancreatic ductal adenocarcinoma (PDAC) is an aggressive solid malignancy with a high rate of metastasis and therapeutic resistance as its major hallmarks…”
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Tumor Cell-Intrinsic p38 MAPK Signaling Promotes IL1α-Mediated Stromal Inflammation and Therapeutic Resistance in Pancreatic Cancer by Singh, Samara P, Dosch, Austin R, Mehra, Siddharth, De Castro Silva, Iago, Bianchi, Anna, Garrido, Vanessa T, Zhou, Zhiqun, Adams, Andrew, Amirian, Haleh, Box, Edmond W, Sun, Xiaodian, Ban, Yuguang, Datta, Jashodeep, Nagathihalli, Nagaraj S, Merchant, Nipun B

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by a KRAS-driven inflammatory program and a desmoplastic stroma, which contribute to the profoundly…”
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A Broad-Based Characterization of a Cell-Penetrating, Single Domain Camelid Bi-Specific Antibody Monomer That Targets STAT3 and KRAS Dependent Cancers by Singh, Sunanda, Murillo, Genoveva, Richner, Justin, Singh, Samara P., Berleth, Erica, Kumar, Vijay, Mehta, Rajendra, Ramiya, Vijay, Parihar, Ashutosh S.

“…STAT3 and KRAS regulate cell proliferation, survival, apoptosis, cell migration, and angiogenesis. Aberrant expression of STAT3 and mutant active forms of KRAS…”
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Remodeling of Stromal Immune Microenvironment by Urolithin A Improves Survival with Immune Checkpoint Blockade in Pancreatic Cancer by Mehra, Siddharth, Garrido, Vanessa T, Dosch, Austin R, Lamichhane, Purushottam, Srinivasan, Supriya, Singh, Samara P, Zhou, Zhiqun, De Castro Silva, Iago, Joshi, Chandrashekar, Ban, Yuguang, Datta, Jashodeep, Gilboa, Eli, Merchant, Nipun B, Nagathihalli, Nagaraj S

“…Pancreatic ductal adenocarcinoma (PDAC) is a significant contributor to cancer-related morbidity and mortality, and it is known for its resistance to…”
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557 Chronicity of exposure and ensuing resistance to platinum chemotherapy sensitizes homologous recombination-deficient pancreatic ductal adenocarcinoma to immune checkpoint blockade by Ogobuiro, Ifeanyichukwu, Bianchi, Anna, Caeiro, Lucas, Amirian, Haleh, Nivelo, Luis Alberto, Silva, Iago De Castro, Rajkumar, Karthik, Adams, Andrew, Garrido, Vanessa, Singh, Samara, Nagathihalli, Nagaraj, Merchant, Nipun, Datta, Jashodeep

“…BackgroundAlthough platinum-based chemotherapy is standard treatment for pancreatic ductal adenocarcinoma (PDAC) patients with either germline/somatic…”
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Microbial influences on severity and sex bias of systemic autoimmunity by Lee, Jean, Reiman, Derek, Singh, Samara, Chang, Anthony, Morel, Laurence, Chervonsky, Alexander V.

“…Summary Commensal microbes have the capacity to affect development and severity of autoimmune diseases. Germ‐free (GF) animals have proven to be a fine tool to…”
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Su1179 MICROBIAL METABOLITE UROLITHIN A REDUCES INFLAMMATION AND ENHANCES GUT BARRIER FUNCTION IN KRASG12D INHIBITOR MRTX1133-TREATED MOUSE MODELS OF PANCREATIC CANCER by Krishnamoorthy, Varunkumar, Mehra, Siddharth, Jinka, Sudhakar, Amirian, Haleh, Box, Edmond Worley, Singh, Samara, Dickey, Erin M., Jala, Venkatakrishna R., Datta, Jashodeep, Merchant, Nipun, Nagathihalli, Nagaraj

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Targeting Tumor-Stromal IL6/STAT3 Signaling through IL1 Receptor Inhibition in Pancreatic Cancer by Dosch, Austin R, Singh, Samara, Dai, Xizi, Mehra, Siddharth, Silva, Iago De Castro, Bianchi, Anna, Srinivasan, Supriya, Gao, Zhen, Ban, Yuguang, Chen, Xi, Banerjee, Sulagna, Nagathihalli, Nagaraj S, Datta, Jashodeep, Merchant, Nipun B

“…A hallmark of pancreatic ductal adenocarcinoma (PDAC) is the presence of a dense, desmoplastic stroma and the consequent altered interactions between cancer…”
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Targeting p38 MAPK Signaling to Suppress Inflammatory Tumor-Stroma-Immune Crosstalk in Pancreatic Cancer by Singh, Samara Parvati

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by uniquely desmoplastic stroma and chronic inflammatory milieu and has posed a major therapeutic…”
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Neutrophil Attenuation Improves Chemosensitivity by Mitigating Inflammatory Polarization of Cancer-Associated Fibroblasts in Pancreatic Cancer by de Castro Silva, Iago, Bianchi, Anna, Deshpande, Nilesh U, Garrido, Vanessa C, Singh, Samara, Mehra, Siddharth, Zhou, Zhiqun, Ogobuiro, Ifeanyichukwu C, Merchant, Nipun B, Datta, Jashodeep

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Interleukin-1 signaling in solid organ malignancies by Dosch, Austin R., Singh, Samara, Nagathihalli, Nagaraj S., Datta, Jashodeep, Merchant, Nipun B.

“…As inflammation plays a critical role in the development and progression of cancer, therapeutic targeting of cytokine pathways involved in both tumorigenesis…”
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Abstract 1544: Cell penetrating single domain antibody (sdAb) SBT-100 binds KRAS and inhibits growth of human cancers with KRAS activating mutations by Singh, Sunanda, Murillo, Genoveva, Singh, Avani, Singh, Samara, Parihar, Meenakshi, Singh, Anjali, Mehta, Rajendra, Parihar, Ashutosh

“…Abstract Background: Despite nearly fourth years of research, scientists have failed to develop a clinically viable therapy against KRAS, one of the deadliest…”
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Distinct mechanisms of innate and adaptive immune regulation underlie poor oncologic outcomes associated with KRAS-TP53 co-alteration in pancreatic cancer by Datta, Jashodeep, Bianchi, Anna, De Castro Silva, Iago, Deshpande, Nilesh U., Cao, Long Long, Mehra, Siddharth, Singh, Samara, Rafie, Christine, Sun, Xiaodian, Chen, Xi, Dai, Xizi, Colaprico, Antonio, Sharma, Prateek, Dosch, Austin R., Pillai, Asha, Hosein, Peter J., Nagathihalli, Nagaraj S., Komanduri, Krishna V., Wilson, Julie M., Ban, Yuguang, Merchant, Nipun B.

“…Co-occurrent KRAS and TP53 mutations define a majority of patients with pancreatic ductal adenocarcinoma (PDAC) and define its pro-metastatic proclivity. Here,…”
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Attenuating Neutrophil-to-lymphocyte Ratio Potentiates Sensitivity to Chemotherapy in a Murine Model of Pancreatic Ductal Adenocarcinoma by de Castro Silva, Iago, Deshpande, Nilesh U., Bianchi, Anna, Sharma, Prateek, Dosch, Austin R., Singh, Samara, Nagathihalli, Nagaraj S., Merchant, Nipun B., Datta, Jashodeep

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The role of the myeloid cells on the development of hepatic metastases in gastrointestinal cancer by Dosch, Austin R., Martos, Mary P., Singh, Samara, Kodia, Karishma, Merchant, Nipun B., Nagathihalli, Nagaraj

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Abstract 5436: Novel single-domain antibody (sdAb), SBT-100, localizes in the cytoplasm to inhibit IL-6 mediated P-STAT3 nuclear translocation in cancer cells by Singh, Sunanda, Murillo, Genoveva, Singh, Avani, Singh, Samara, Parihar, Meenakshi, Mehta, Rajendra, Singh, Anjali, Parihar, Ashutosh

“…Abstract BACKGROUND: Interleukin-6 (IL-6) is a multifunctional cytokine that is involved in immune defense and plays an important role in biologic activities…”
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Cell-Autonomous Cxcl1 Sustains Tolerogenic Circuitries and Stromal Inflammation via Neutrophil-Derived TNF in Pancreatic Cancer by Bianchi, Anna, De Castro Silva, Iago, Deshpande, Nilesh U, Singh, Samara, Mehra, Siddharth, Garrido, Vanessa T, Guo, Xinyu, Nivelo, Luis A, Kolonias, Despina S, Saigh, Shannon J, Wieder, Eric, Rafie, Christine I, Dosch, Austin R, Zhou, Zhiqun, Umland, Oliver, Amirian, Haleh, Ogobuiro, Ifeanyichukwu C, Zhang, Jian, Ban, Yuguang, Shiau, Carina, Nagathihalli, Nagaraj S, Montgomery, Elizabeth A, Hwang, William L, Brambilla, Roberta, Komanduri, Krishna, Villarino, Alejandro V, Toska, Eneda, Stanger, Ben Z, Gabrilovich, Dmitry I, Merchant, Nipun B, Datta, Jashodeep

“…We have shown that KRAS-TP53 genomic coalteration is associated with immune-excluded microenvironments, chemoresistance, and poor survival in pancreatic ductal…”
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Abstract PO-056: Targeting of cancer associated fibroblast-specific MEK1 and STAT3 to overcome immunosuppressive microenvironment in Pancreatic Ductal Adenocarcinoma (PDAC) by Mehra, Siddharth, Dai, Xizi, Bianchi, Anna, Dosch, Austin, de Castro Silva, Iago, Sharma, Prateek, Singh, Samara, Srinivasan, Supriya, Nagathihalli, Nagaraj, Datta, Jashodeep, Merchant, Nipun

“…Abstract Background Activating KRAS mutations, stromal desmoplasia, and immune exclusion are fundamental to therapeutic resistance in PDAC. We have previously…”
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