Search Results - "Singh, Rashim Pal"

Loss of Epithelial Hypoxia-Inducible Factor Prolyl Hydroxylase 2 Accelerates Skin Wound Healing in Mice by Kalucka, Joanna, Ettinger, Andreas, Franke, Kristin, Mamlouk, Soulafa, Singh, Rashim Pal, Farhat, Katja, Muschter, Antje, Olbrich, Susanne, Breier, Georg, Katschinski, Dörthe M., Huttner, Wieland, Weidemann, Alexander, Wielockx, Ben

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Loss of prolyl hydroxylase‐2 in myeloid cells and T‐lymphocytes impairs tumor development by Mamlouk, Soulafa, Kalucka, Joanna, Singh, Rashim Pal, Franke, Kristin, Muschter, Antje, Langer, Anika, Jakob, Christiane, Gassmann, Max, Baretton, Gustavo B., Wielockx, Ben

“…The tumor microenvironment plays a pivotal role during cancer development and progression. The balance between suppressive and cytotoxic responses of the tumor…”
Get full text

Iron- and erythropoietin-resistant anemia in a spontaneous breast cancer mouse model by Bregolat, Nuria Fabregas, Ruetten, Maja, Da Silva, Milene Costa, Aboouf, Mostafa A., Ademi, Hyrije, Büren, Nadine von, Armbruster, Julia, Stirn, Martina, Altamura, Sandro, Marques, Oriana, Rodriguez, Josep M. Monné, Samillan, Victor J., Singh, Rashim Pal, Wielockx, Ben, Muckenthaler, Martina U., Gassmann, Max, Thiersch, Markus

“…Anemia of cancer (AoC) with its multifactorial etiology and complex pathology is a poor prognostic indicator for cancer patients. One of the main causes of AoC…”
Get full text

Mitochondria regulate AML differentiation independent of oxidative phosphorylation and metabolism by Singh, Rashim Pal, Schimmer, Aaron D

Get full text

Hypoxia-mediated regulation of stem cell fate by Singh, Rashim Pal, Franke, Kristin, Wielockx, Ben

“…Hypoxia-mediated regulation of stem cell fate, or reduced oxygen availability, is a prominent feature during mammalian development and under physiological and…”
Get more information

HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress by Singh, Rashim Pal, Franke, Kristin, Kalucka, Joanna, Mamlouk, Soulafa, Muschter, Antje, Gembarska, Agnieszka, Grinenko, Tatyana, Willam, Carsten, Naumann, Ronald, Anastassiadis, Konstantinos, Stewart, A. Francis, Bornstein, Stefan, Chavakis, Triantafyllos, Breier, Georg, Waskow, Claudia, Wielockx, Ben

“…Hypoxia is a prominent feature in the maintenance of hematopoietic stem cell (HSC) quiescence and multipotency. Hypoxia-inducible factor (HIF) prolyl…”
Get full text

Transduction of Primary AML Cells with Lentiviral Vector for In Vitro Study or In Vivo Engraftment by Schimmer, Aaron D., Singh, Rashim Pal, Seneviratne, Ayesh K., Thomas, Geethu E., MacLean, Neil, Hurren, Rose

“…We describe a method to silence genes in primary acute myeloid leukemia cells by transducing them with shRNA in lentiviral vectors. The transduction of primary…”
Get full text

Evaluation of copper toxicity in isolated human peripheral blood mononuclear cells and it's attenuation by zinc: ex vivo by Singh, Rashim Pal, Kumar, Sandeep, Nada, Ritambra, Prasad, Rajendra

“…Copper and zinc act as a cofactor of over 300 mammalian proteins. Both have same electronic configuration therefore they are antagonist at higher individual…”
Get full text

Secreted protein Del-1 regulates myelopoiesis in the hematopoietic stem cell niche by Mitroulis, Ioannis, Chen, Lan-Sun, Singh, Rashim Pal, Kourtzelis, Ioannis, Economopoulou, Matina, Kajikawa, Tetsuhiro, Troullinaki, Maria, Ziogas, Athanasios, Ruppova, Klara, Hosur, Kavita, Maekawa, Tomoki, Wang, Baomei, Subramanian, Pallavi, Tonn, Torsten, Verginis, Panayotis, von Bonin, Malte, Wobus, Manja, Bornhäuser, Martin, Grinenko, Tatyana, Di Scala, Marianna, Hidalgo, Andres, Wielockx, Ben, Hajishengallis, George, Chavakis, Triantafyllos

“…Hematopoietic stem cells (HSCs) remain mostly quiescent under steady-state conditions but switch to a proliferative state following hematopoietic stress, e.g.,…”
Get full text

Increased EPO Levels Are Associated With Bone Loss in Mice Lacking PHD2 in EPO‐Producing Cells by Rauner, Martina, Franke, Kristin, Murray, Marta, Singh, Rashim Pal, Hiram‐Bab, Sahar, Platzbecker, Uwe, Gassmann, Max, Socolovsky, Merav, Neumann, Drorit, Gabet, Yankel, Chavakis, Triantafyllos, Hofbauer, Lorenz C, Wielockx, Ben

“…ABSTRACT The main oxygen sensor hypoxia inducible factor (HIF) prolyl hydroxylase 2 (PHD2) is a critical regulator of tissue homeostasis during erythropoiesis,…”
Get full text

Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal by Singh, Rashim Pal, Jeyaraju, Danny V., Voisin, Veronique, Hurren, Rose, Xu, Changjiang, Hawley, James R., Barghout, Samir H., Khan, Dilshad H., Gronda, Marcela, Wang, Xiaoming, Jitkova, Yulia, Sharon, David, Liyanagae, Sanduni, MacLean, Neil, Seneviratene, Ayesh K., Mirali, Sara, Borenstein, Adina, Thomas, Geethu E., Soriano, Joelle, Orouji, Elias, Minden, Mark D., Arruda, Andrea, Chan, Steven M., Bader, Gary D., Lupien, Mathieu, Schimmer, Aaron D.

“…Leukemic stem cells (LSCs) rely on oxidative metabolism and are differentially sensitive to targeting mitochondrial pathways, which spares normal hematopoietic…”
Get full text

Identification of an optimized Receptor-Binding Domain Subunit Vaccine against SARS-CoV-2 by Yu, Hong, Worrall, Liam J, Berger, Thorsten, Petric, Martin, Lin, Bryan H, Vuckovic, Marija, Robb, Craig S, Le, Quan, Kenward, Calem, Dai, Chuanbin, Wakeham, Andrew, Liu, Shaofeng, Snow, Bryan, Tobin, Chantal, Budylowski, Patrick, Guvenc, Furkan, You-Ten, Annick, Haight, Jillian, Silvester, Jennifer, Singh, Rashim Pal, Ahn, Sang Kyun, Sultana, Azmiri, Poon, Betty, Lam, Jessica, Christie-Holmes, Natasha, Ostrowski, Mario, Gray-Owen, Scott D, Kubli, Shawn, Mak, Tak, Strynadka, Natalie C J, Brunham, Robert C

“…Current vaccine efforts to combat SARS-CoV-2 are focused on the whole spike protein administered as mRNA, viral vector, or protein subunit. However, the…”
Get full text

Hematopoietic Stem Cells but Not Multipotent Progenitors Drive Erythropoiesis during Chronic Erythroid Stress in EPO Transgenic Mice by Singh, Rashim Pal, Grinenko, Tatyana, Ramasz, Beáta, Franke, Kristin, Lesche, Mathias, Dahl, Andreas, Gassmann, Max, Chavakis, Triantafyllos, Henry, Ian, Wielockx, Ben

“…The hematopoietic stem cell (HSC) compartment consists of a small pool of cells capable of replenishing all blood cells. Although it is established that the…”
Get full text

HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α–induced excessive erythropoiesis by Franke, Kristin, Kalucka, Joanna, Mamlouk, Soulafa, Singh, Rashim Pal, Muschter, Antje, Weidemann, Alexander, Iyengar, Vasuprada, Jahn, Steffen, Wieczorek, Kathrin, Geiger, Kathrin, Muders, Michael, Sykes, Alex M., Poitz, David M., Ripich, Tatsiana, Otto, Teresa, Bergmann, Sybille, Breier, Georg, Baretton, Gustavo, Fong, Guo-Hua, Greaves, David R., Bornstein, Stefan, Chavakis, Triantafyllos, Fandrey, Joachim, Gassmann, Max, Wielockx, Ben

“…Erythropoiesis must be tightly balanced to guarantee adequate oxygen delivery to all tissues in the body. This process relies predominantly on the hormone…”
Get full text

Targeting the Mitochondrial Metallochaperone Cox17 Reduces DNA Methylation and Promotes AML Differentiation through a Copper Dependent Mechanism by Singh, Rashim Pal, Jeyaraju, Danny V., Voisin, Veronique, Xu, Changjiang, Barghout, Samir H, Khan, Dilshad H., Hurren, Rose, Gronda, Marcela, Wang, Xiaoming, Jitkova, Yulia, Sharon, David, Liyanage, Sanduni U., Soriano, Joelle, Lechman, Eric R., MacLean, Neil, Minden, Mark D., Chan, Steven M, Dick, John E., Bader, Gary D, Schimmer, Aaron

“…The majority of mitochondrial proteins are encoded in the nucleus, translated in the cytoplasm and imported into the mitochondria. A subset of cysteine-rich…”
Get full text