Search Results - "Singh, Pankaj K"

Nucleotide metabolism: a pan-cancer metabolic dependency by Mullen, Nicholas J., Singh, Pankaj K.

“…Metabolic alterations are a key hallmark of cancer cells, and the augmented synthesis and use of nucleotide triphosphates is a critical and universal metabolic…”
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Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer by Bryant, Kirsten L., Stalnecker, Clint A., Zeitouni, Daniel, Klomp, Jennifer E., Peng, Sen, Tikunov, Andrey P., Gunda, Venugopal, Pierobon, Mariaelena, Waters, Andrew M., George, Samuel D., Tomar, Garima, Papke, Björn, Hobbs, G. Aaron, Yan, Liang, Hayes, Tikvah K., Diehl, J. Nathaniel, Goode, Gennifer D., Chaika, Nina V., Wang, Yingxue, Zhang, Guo-Fang, Witkiewicz, Agnieszka K., Knudsen, Erik S., Petricoin, Emanuel F., Singh, Pankaj K., Macdonald, Jeffrey M., Tran, Nhan L., Lyssiotis, Costas A., Ying, Haoqiang, Kimmelman, Alec C., Cox, Adrienne D., Der, Channing J.

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by KRAS- and autophagy-dependent tumorigenic growth, but the role of KRAS in supporting autophagy has…”
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Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation by Lee, Joo-Hyung, Wang, Ruoyu, Xiong, Feng, Krakowiak, Joanna, Liao, Zian, Nguyen, Phuoc T., Moroz-Omori, Elena V., Shao, Jiaofang, Zhu, Xiaoyu, Bolt, Michael J., Wu, Haoyi, Singh, Pankaj K., Bi, Mingjun, Shi, Caleb J., Jamal, Naadir, Li, Guojie, Mistry, Ragini, Jung, Sung Yun, Tsai, Kuang-Lei, Ferreon, Josephine C., Stossi, Fabio, Caflisch, Amedeo, Liu, Zhijie, Mancini, Michael A., Li, Wenbo

“…The mechanistic understanding of nascent RNAs in transcriptional control remains limited. Here, by a high sensitivity method methylation-inscribed nascent…”
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Discovery of novel functionalized 1,2,4-triazoles as PARP-1 inhibitors in breast cancer: Design, synthesis and antitumor activity evaluation by Boraei, Ahmed T.A., Singh, Pankaj K., Sechi, Mario, Satta, Sandro

“…PARP-1, a nuclear protein, is one of the key member of the DNA repair assembly and thereby emerged as an attractive target in anti-cancer drug discovery…”
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The human AP-endonuclease 1 (APE1) is a DNA G-quadruplex structure binding protein and regulates KRAS expression in pancreatic ductal adenocarcinoma cells by Pramanik, Suravi, Chen, Yingling, Song, Heyu, Khutsishvili, Irine, Marky, Luis A, Ray, Sutapa, Natarajan, Amarnath, Singh, Pankaj K, Bhakat, Kishor K

“…Abstract Pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive types of cancer, is characterized by aberrant activity of oncogenic KRAS. A…”
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De Novo Lipid Synthesis Facilitates Gemcitabine Resistance through Endoplasmic Reticulum Stress in Pancreatic Cancer by Tadros, Saber, Shukla, Surendra K, King, Ryan J, Gunda, Venugopal, Vernucci, Enza, Abrego, Jaime, Chaika, Nina V, Yu, Fang, Lazenby, Audrey J, Berim, Lyudmyla, Grem, Jean, Sasson, Aaron R, Singh, Pankaj K

“…Pancreatic adenocarcinoma is moderately responsive to gemcitabine-based chemotherapy, the most widely used single-agent therapy for pancreatic cancer. Although…”
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O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity by Li, Tianliang, Li, Xinghui, Attri, Kuldeep S., Liu, Changhong, Li, Lupeng, Herring, Laura E., Asara, John M., Lei, Yu L., Singh, Pankaj K., Gao, Chengjiang, Wen, Haitao

“…Increased glucose metabolism in immune cells not only serves as a hallmark feature of acute inflammation but also profoundly affects disease outcome following…”
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O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3 by Li, Xinghui, Gong, Wei, Wang, Hao, Li, Tianliang, Attri, Kuldeep S., Lewis, Robert E., Kalil, Andre C., Bhinderwala, Fatema, Powers, Robert, Yin, Guowei, Herring, Laura E., Asara, John M., Lei, Yu L., Yang, Xiaoyong, Rodriguez, Diego A., Yang, Mao, Green, Douglas R., Singh, Pankaj K., Wen, Haitao

“…Elevated glucose metabolism in immune cells represents a hallmark feature of many inflammatory diseases, such as sepsis. However, the role of individual…”
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Phosphoinositide 3-Kinase Signaling Pathway in Pancreatic Ductal Adenocarcinoma Progression, Pathogenesis, and Therapeutics by Murthy, Divya, Attri, Kuldeep S, Singh, Pankaj K

“…Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by its sudden manifestation, rapid progression, poor prognosis, and…”
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Monocyte metabolic reprogramming promotes pro-inflammatory activity and Staphylococcus aureus biofilm clearance by Yamada, Kelsey J, Heim, Cortney E, Xi, Xinyuan, Attri, Kuldeep S, Wang, Dezhen, Zhang, Wenting, Singh, Pankaj K, Bronich, Tatiana K, Kielian, Tammy

“…Biofilm-associated prosthetic joint infections (PJIs) cause significant morbidity due to their recalcitrance to immune-mediated clearance and antibiotics, with…”
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GOT1-Mediated Anaplerotic Glutamine Metabolism Regulates Chronic Acidosis Stress In Pancreatic Cancer Cells by Abrego, Jaime, Gunda, Venugopal, Vernucci, Enza, Shukla, Surendra K, King, Ryan J, Dasgupta, Aneesha, Goode, Gennifer, Murthy, Divya, Yu, Fang, Singh, Pankaj K

“…Abstract The increased rate of glycolysis and reduced oxidative metabolism are the principal biochemical phenotypes observed in pancreatic ductal…”
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Fascin Controls Metastatic Colonization and Mitochondrial Oxidative Phosphorylation by Remodeling Mitochondrial Actin Filaments by Lin, Shengchen, Huang, Chongbiao, Gunda, Venugopal, Sun, Jianwei, Chellappan, Srikumar P., Li, Zengxun, Izumi, Victoria, Fang, Bin, Koomen, John, Singh, Pankaj K., Hao, Jihui, Yang, Shengyu

“…The deregulation of the actin cytoskeleton has been extensively studied in metastatic dissemination. However, the post-dissemination role of the actin…”
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Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression by Hu, Tuo, Shukla, Surendra K., Vernucci, Enza, He, Chunbo, Wang, Dezhen, King, Ryan J., Jha, Kanupriya, Siddhanta, Kasturi, Mullen, Nicholas J., Attri, Kuldeep S., Murthy, Divya, Chaika, Nina V., Thakur, Ravi, Mulder, Scott E., Pacheco, Camila G., Fu, Xiao, High, Robin R., Yu, Fang, Lazenby, Audrey, Steegborn, Clemens, Lan, Ping, Mehla, Kamiya, Rotili, Dante, Chaudhary, Sarika, Valente, Sergio, Tafani, Marco, Mai, Antonello, Auwerx, Johan, Verdin, Eric, Tuveson, David, Singh, Pankaj K.

“…SIRT5 plays pleiotropic roles via post-translational modifications, serving as a tumor suppressor, or an oncogene, in different tumors. However, the role SIRT5…”
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The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition by Goodwin, Justin, Neugent, Michael L., Lee, Shin Yup, Choe, Joshua H., Choi, Hyunsung, Jenkins, Dana M. R., Ruthenborg, Robin J., Robinson, Maddox W., Jeong, Ji Yun, Wake, Masaki, Abe, Hajime, Takeda, Norihiko, Endo, Hiroko, Inoue, Masahiro, Xuan, Zhenyu, Yoo, Hyuntae, Chen, Min, Ahn, Jung-Mo, Minna, John D., Helke, Kristi L., Singh, Pankaj K., Shackelford, David B., Kim, Jung-whan

“…Adenocarcinoma (ADC) and squamous cell carcinoma (SqCC) are the two predominant subtypes of non-small cell lung cancer (NSCLC) and are distinct in their…”
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Sonic Hedgehog Promotes Desmoplasia in Pancreatic Cancer by BAILEY, Jennifer M, SWANSON, Benjamin J, HAMADA, Tomofumi, EGGERS, John P, SINGH, Pankaj K, CAFFERY, Thomas, OUELLETTE, Michel M, HOLLINGSWORTH, Michael A

“…Purpose: We investigated the contribution of Sonic hedgehog (SHH) to pancreatic cancer progression. Experimental Design: We expressed SHH in a transformed…”
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Validation of Metabolic Alterations in Microscale Cell Culture Lysates Using Hydrophilic Interaction Liquid Chromatography (HILIC)-Tandem Mass Spectrometry-Based Metabolomics by Gunda, Venugopal, Yu, Fang, Singh, Pankaj K

“…By standard convention, in order to increase the efficacy of metabolite detection from cell culture lysates, metabolite extracts from a large quantity of cells…”
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MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer by Chaika, Nina V, Gebregiworgis, Teklab, Lewallen, Michelle E, Purohit, Vinee, Radhakrishnan, Prakash, Liu, Xiang, Zhang, Bo, Mehla, Kamiya, Brown, Roger B, Caffrey, Thomas, Yu, Fang, Johnson, Keith R, Powers, Robert, Hollingsworth, Michael A, Singh, Pankaj K

“…Aberrant glucose metabolism is one of the hallmarks of cancer that facilitates cancer cell survival and proliferation. Here, we demonstrate that MUC1, a large,…”
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MUC1 facilitates metabolomic reprogramming in triple-negative breast cancer by Goode, Gennifer, Gunda, Venugopal, Chaika, Nina V, Purohit, Vinee, Yu, Fang, Singh, Pankaj K

“…Mucin1 (MUC1), a glycoprotein associated with chemoresistance and an aggressive cancer phenotype, is aberrantly overexpressed in triple-negative breast cancer…”
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Nanotechnological Advances for Nose to Brain Delivery of Therapeutics to Improve the Parkinson Therapy by Khatri, Dharmendra K, Preeti, Kumari, Tonape, Shivraj, Bhattacharjee, Sheoshree, Patel, Monica, Shah, Saurabh, Singh, Pankaj K, Srivastava, Saurabh, Gugulothu, Dalapathi, Vora, Lalitkumar, Singh, Shashi B

“…Blood-Brain Barrier (BBB) acts as a highly impermeable barrier, presenting an impediment to the crossing of most classical drugs targeted for neurodegenerative…”
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Cancer metastasis facilitated by developmental pathways: Sonic hedgehog, Notch, and bone morphogenic proteins by Bailey, Jennifer M., Singh, Pankaj K., Hollingsworth, Michael A.

“…This review will highlight the significance of three critical pathways in developmental biology and our emerging understanding of their roles in regulating…”
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