Search Results - "Singh, Maneesh N."

Infrared spectroscopy as a new approach for early fabry disease screening: a pilot study by Barretto, Carolina Teles, Nascimento, Márcia Helena Cassago, Brun, Bruna Ferro, da Silva, Tiago Barcelos, Dias, Pedro Augusto Costa, Silva, Cassiano Augusto Braga, Singh, Maneesh N, Martin, Francis L, Filgueiras, Paulo Roberto, Romão, Wanderson, Campos, Luciene Cristina Gastalho, Barauna, Valerio Garrone

“…Fabry disease (FD) is a rare X-linked lysosomal storage disorder marked by alpha-galactosidase-A (α-Gal A) deficiency, caused by pathogenic mutations in the…”
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Ultrarapid On-Site Detection of SARS-CoV‑2 Infection Using Simple ATR-FTIR Spectroscopy and an Analysis Algorithm: High Sensitivity and Specificity by Barauna, Valério G, Singh, Maneesh N, Barbosa, Leonardo Leal, Marcarini, Wena Dantas, Vassallo, Paula Frizera, Mill, Jose Geraldo, Ribeiro-Rodrigues, Rodrigo, Campos, Luciene C. G, Warnke, Patrick H, Martin, Francis L

“…There is an urgent need for ultrarapid testing regimens to detect the severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2] infections in real-time…”
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Fast screening using attenuated total reflectance- fourier transform infrared (ATR-FTIR) spectroscopy of patients based on D-dimer threshold value by Brun, Bruna F., Nascimento, Marcia H.C., Dias, Pedro A.C., Marcarini, Wena D., Singh, Maneesh N., Filgueiras, Paulo R., Vassallo, Paula F., Romão, Wanderson, Mill, José G., Martin, Francis L., Barauna, Valerio G.

“…Attenuated Total Reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy is an emerging technology in the medical field. Blood D-dimer was initially…”
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ATR-FTIR Spectroscopy with Chemometrics for Analysis of Saliva Samples Obtained in a Lung-Cancer-Screening Programme: Application of Swabs as a Paradigm for High Throughput in a Clinical Setting by Martin, Francis L, Dickinson, Andrew W, Saba, Tarek, Bongers, Thomas, Singh, Maneesh N, Bury, Danielle

“…There is an increasing need for inexpensive and rapid screening tests in point-of-care clinical oncology settings. Herein, we develop a swab "dip" test in…”
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FTIR Microspectroscopy Coupled with Two-Class Discrimination Segregates Markers Responsible for Inter- and Intra-Category Variance in Exfoliative Cervical Cytology by Walsh, Michael J, Singh, Maneesh N, Stringfellow, Helen F, Pollock, Hubert M, Hammiche, Azzedine, Grude, Olaug, Fullwood, Nigel J, Pitt, Mark A, Martin-Hirsch, Pierre L, Martin, Francis L

“…Infrared (IR) absorbance of cellular biomolecules generates a vibrational spectrum, which can be exploited as a "biochemical fingerprint" of a particular cell…”
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MALDI(+) FT-ICR Mass Spectrometry (MS) Combined with Machine Learning toward Saliva-Based Diagnostic Screening for COVID-19 by de Almeida, Camila M., Motta, Larissa C., Folli, Gabriely S., Marcarini, Wena D., Costa, Camila A., Vilela, Ana C. S., Barauna, Valério G., Martin, Francis L., Singh, Maneesh N., Campos, Luciene C. G., Costa, Nádia L., Vassallo, Paula F., Chaves, Andrea R., Endringer, Denise C., Mill, José G., Filgueiras, Paulo R., Romão, Wanderson

“…Rapid identification of existing respiratory viruses in biological samples is of utmost importance in strategies to combat pandemics. Inputting MALDI FT-ICR MS…”
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FTIR Microspectroscopy Coupled with Two-Class Discrimination Segregates Markers Responsible for Inter- and Intra-Category Variance in Exfoliative Cervical Cytology by Walsh, Michael J., Singh, Maneesh N., Stringfellow, Helen F., Pollock, Hubert M., Hammiche, Azzedine, Grude, Olaug, Fullwood, Nigel J., Pitt, Mark A., Martin-Hirsch, Pierre L., Martin, Francis L.

“…Michael J. Walsh1, Maneesh N. Singh1,2, Helen F. Stringfellow2, Hubert M. Pollock3, Azzedine Hammiche3, Olaug Grude3, Nigel J. Fullwood1, Mark A. Pitt2, Pierre…”
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Point-of-Care Disease Screening in Primary Care Using Saliva: A Biospectroscopy Approach for Lung Cancer and Prostate Cancer by Martin, Francis L., Morais, Camilo L. M., Dickinson, Andrew W., Saba, Tarek, Bongers, Thomas, Singh, Maneesh N., Bury, Danielle

“…Saliva is a largely unexplored liquid biopsy that can be readily obtained noninvasively. Not dissimilar to blood plasma or serum, it contains a vast array of…”
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Near-Infrared Spectroscopy with Supervised Machine Learning as a Screening Tool for Neutropenia by Raposo-Neto, José Joaquim, Kowalski-Neto, Eduardo, Luiz, Wilson Barros, Fonseca, Estherlita Almeida, Cedro, Anna Karla Costa Logrado, Singh, Maneesh N, Martin, Francis L, Vassallo, Paula Frizera, Campos, Luciene Cristina Gastalho, Barauna, Valerio Garrone

“…The use of non-invasive tools in conjunction with artificial intelligence (AI) to detect diseases has the potential to revolutionize healthcare. Near-infrared…”
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γ-Synuclein and the progression of cancer by Ahmad, Mushfika, Attoub, Samir, Singh, Maneesh N, Martin, Francis L, El-Agnaf, Omar M.A

“…The synucleins are a small, soluble, highly conserved group of neuronal proteins that have been implicated in both neurodegenerative diseases and cancer. The…”
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ATR microspectroscopy with multivariate analysis segregates grades of exfoliative cervical cytology by Walsh, Michael J., Singh, Maneesh N., Pollock, Hubert M., Cooper, Leanne J., German, Matthew J., Stringfellow, Helen F., Fullwood, Nigel J., Paraskevaidis, Evangelos, Martin-Hirsch, Pierre L., Martin, Francis L.

“…Although cervical cancer screening in the UK has led to reductions in the incidence of invasive disease, this programme remains flawed. We set out to examine…”
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Tamoxifen: Important considerations of a multi-functional compound with organ-specific properties by Singh, Maneesh N, Stringfellow, Helen F, Paraskevaidis, Evangelos, Martin-Hirsch, Pierre L, Martin, Francis L

“…Summary Tamoxifen remains a frontline treatment for hormone-responsive breast cancer despite its use being associated with a 2–7-fold elevated risk of…”
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Incarcerated Retroverted Uterus in the Third Trimester Complicated by Postpartum Pulmonary Embolism by Singh, Maneesh N., Payappagoudar, Jayashri, Lo, Jenny, Prashar, Sanjeev

“…Incarceration of the retroverted gravid uterus is an extremely rare diagnosis in the third trimester that carries significant maternal operative and…”
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Fourier-transform infrared spectroscopy discriminates a spectral signature of endometriosis independent of inter-individual variation by Cheung, Karen T, Trevisan, Júlio, Kelly, Jemma G, Ashton, Katherine M, Stringfellow, Helen F, Taylor, Siân E, Singh, Maneesh N, Martin-Hirsch, Pierre L, Martin, Francis L

“…Endometriosis is the growth of endometrial tissue outside of the uterine cavity. Its aetiology remains obscure, and it is difficult to diagnose ranging from…”
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Metastatic colon adenocarcinoma to the placenta by Matsika, Admire, Wright, Garfield R.O., Singh, Maneesh N., Smith, Jason D., Bligh, Judith F.

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Derivation of a subtype-specific biochemical signature of endometrial carcinoma using synchrotron-based Fourier-transform infrared microspectroscopy by Kelly, Jemma G, Singh, Maneesh N, Stringfellow, Helen F, Walsh, Michael J, Nicholson, James M, Bahrami, Fariba, Ashton, Katherine M, Pitt, Mark A, Martin-Hirsch, Pierre L, Martin, Francis L

“…Abstract Endometrial carcinoma consists of endometrioid (type I) and serous papillary (SP; type II) subtypes; a rarer form is malignant mixed müllerian tumours…”
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Elevated expression of CYP1A1 and γ-SYNUCLEIN in human ectopic (ovarian) endometriosis compared with eutopic endometrium by Singh, Maneesh N., Stringfellow, Helen F., Taylor, Siân E., Ashton, Kate M., Ahmad, Mushfika, Abdo, Khalil R., El-Agnaf, Omar M.A., Martin-Hirsch, Pierre L., Martin, Francis L.

“…Endometriosis is a debilitating disease in which apoptotic, genetic, immunological, angiogenic and environmental factors have been implicated…”
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Quantifiable mRNA transcripts for tamoxifen-metabolising enzymes in human endometrium by Singh, Maneesh N, Stringfellow, Helen F, Walsh, Michael J, Ashton, Kate M, Paraskevaidis, Evangelos, Abdo, Khalil R, Martin-Hirsch, Pierre L, Phillips, David H, Martin, Francis L

“…Abstract Tamoxifen has been used in the management of receptor-positive breast cancer for >20 years. Usage confers an elevated risk of developing endometrial…”
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Detection and quantification using ATR-FTIR spectroscopy of whey protein concentrate adulteration with wheat flour by Martins, Matthews S., Nascimento, Márcia H., Barbosa, Leonardo L., Campos, Luciene C.G., Singh, Maneesh N., Martin, Francis L., Romão, Wanderson, Filgueiras, Paulo R., Barauna, Valério G.

“…Expensive and time-consuming methods are currently used to identify manipulated whey protein concentrate (WPC). We tested the application of attenuated total…”
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The multiple applications of tamoxifen: an example pointing to SERM modulation being the aspirin of the 21st century by Singh, Maneesh N, Martin-Hirsch, Pierre L, Martin, Francis L

“…Tamoxifen is a selective oestrogen receptor modulator (SERM) with an established role in the treatment and chemoprevention of hormone-related breast cancer. It…”
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