Search Results - "Singh, Mallika"

Modeling and predicting clinical efficacy for drugs targeting the tumor milieu by Singh, Mallika, Ferrara, Napoleone

“…Disappointing results from most late-stage clinical trials of cancer therapeutics indicate a need for improved and more-predictive animal tumor models. This…”
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RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers by Nichols, Robert J., Haderk, Franziska, Stahlhut, Carlos, Schulze, Christopher J., Hemmati, Golzar, Wildes, David, Tzitzilonis, Christos, Mordec, Kasia, Marquez, Abby, Romero, Jason, Hsieh, Tientien, Zaman, Aubhishek, Olivas, Victor, McCoach, Caroline, Blakely, Collin M., Wang, Zhengping, Kiss, Gert, Koltun, Elena S., Gill, Adrian L., Singh, Mallika, Goldsmith, Mark A., Smith, Jacqueline A. M., Bivona, Trever G.

“…Oncogenic alterations in the RAS/RAF/MEK/ERK pathway drive the growth of a wide spectrum of cancers. While BRAF and MEK inhibitors are efficacious against BRAF…”
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Systematic evaluation of common natural language processing techniques to codify clinical notes by Tavabi, Nazgol, Singh, Mallika, Pruneski, James, Kiapour, Ata M

“…Proper codification of medical diagnoses and procedures is essential for optimized health care management, quality improvement, research, and reimbursement…”
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Genetically Engineered Mouse Models: Closing the Gap between Preclinical Data and Trial Outcomes by SINGH, Mallika, MURRIEL, Christopher L, JOHNSON, Leisa

“…The high failure rate of late-stage human clinical trials, particularly in oncology, predicates the need for improved translation of preclinical data from…”
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Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression by Shojaei, Farbod, Singh, Mallika, Thompson, Jennifer D, Ferrara, Napoleone

“…The secreted Bv8 protein has been recently characterized as a regulator of myeloid cell mobilization and a neutrophil-derived mediator of tumor angiogenesis in…”
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Bi-steric mTORC1 inhibitors induce apoptotic cell death in tumor models with hyperactivated mTORC1 by Du, Heng, Yang, Yu Chi, Liu, Heng-Jia, Yuan, Min, Asara, John M, Wong, Kwok-Kin, Henske, Elizabeth P, Singh, Mallika, Kwiatkowski, David J

“…The PI3K/AKT/mTOR pathway is commonly dysregulated in cancer. Rapalogs exhibit modest clinical benefit, likely owing to their lack of effects on 4EBP1. We…”
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Using Genetically Engineered Mouse Models of Cancer to Aid Drug Development: An Industry Perspective by Singh, Mallika, Johnson, Leisa

“…Recent developments in the generation and characterization of genetically engineered mouse models of human cancer have resulted in notable improvements in…”
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Combined inhibition of KRASG12C and mTORC1 kinase is synergistic in non-small cell lung cancer by Kitai, Hidenori, Choi, Philip H., Yang, Yu C., Boyer, Jacob A., Whaley, Adele, Pancholi, Priya, Thant, Claire, Reiter, Jason, Chen, Kevin, Markov, Vladimir, Taniguchi, Hirokazu, Yamaguchi, Rui, Ebi, Hiromichi, Evans, James, Jiang, Jingjing, Lee, Bianca, Wildes, David, de Stanchina, Elisa, Smith, Jacqueline A. M., Singh, Mallika, Rosen, Neal

“…Current KRAS G12C (OFF) inhibitors that target inactive GDP-bound KRAS G12C cause responses in less than half of patients and these responses are not durable…”
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Barriers to point-of-care ultrasound utilization during cardiac arrest in the emergency department: a regional survey of emergency physicians by Singh, Mallika R., Jackson, Jennifer S., Newberry, Mark A., Riopelle, Cameron, Tran, Vu Huy, PoSaw, Leila L.

“…Though point-of-care ultrasound (POCUS) is recognized as a useful diagnostic and prognostic intervention during cardiac arrest (CA), critics advise caution…”
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An integrative analysis of colon cancer identifies an essential function for PRPF6 in tumor growth by Adler, Adam S, McCleland, Mark L, Yee, Sharon, Yaylaoglu, Murat, Hussain, Sofia, Cosino, Ely, Quinones, Gabriel, Modrusan, Zora, Seshagiri, Somasekar, Torres, Eric, Chopra, Vivek S, Haley, Benjamin, Zhang, Zemin, Blackwood, Elizabeth M, Singh, Mallika, Junttila, Melissa, Stephan, Jean-Philippe, Liu, Jinfeng, Pau, Gregoire, Fearon, Eric R, Jiang, Zhaoshi, Firestein, Ron

“…The spliceosome machinery is composed of multimeric protein complexes that generate a diverse repertoire of mRNA through coordinated splicing of heteronuclear…”
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Effects of Anti-VEGF Treatment Duration on Tumor Growth, Tumor Regrowth, and Treatment Efficacy by BAGRI, Anil, BERRY, Leanne, ROSEN, Oliver, PLOWMAN, Greg D, GUNTER, Bert, SINGH, Mallika, KASMAN, Ian, DAMICO, Lisa A, HONG XIANG, SCHMIDT, Maike, FUH, Germaine, HOLLISTER, Beth

“…Inhibition of the vascular endothelial growth factor (VEGF) axis is the basis of all currently approved antiangiogenic therapies. In preclinical models,…”
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Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity by Myers, Darienne R, Abram, Clare L, Wildes, David, Belwafa, Amira, Welsh, Alia M N, Schulze, Christopher J, Choy, Tiffany J, Nguyen, Tram, Omaque, Neil, Hu, Yongmei, Singh, Mallika, Hansen, Rich, Goldsmith, Mark A, Quintana, Elsa, Smith, Jacqueline A M, Lowell, Clifford A

“…Shp1, encoded by the gene , is a protein tyrosine phosphatase that transduces inhibitory signals downstream of immunoreceptors in many immune cell types…”
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Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models by Hamilton, Patricia, Devasthali, Vidusha, Bou Reslan, Hani, Nannini, Michelle A, Cheng, Jason H, Johnson, Leisa, Ho, Calvin C K, Lee, Chingwei V, Fuh, Germaine, Forrest, William F, Molina, Rafael, Clermont, Anne C, Cao, Timothy C, Carano, Richard A D, Yu, Ron X, Koeppen, Hartmut, Plowman, Gregory D, Singh, Mallika, Lima, Anthony, Thompson, Jennifer D

“…Genetically engineered mouse models of cancer simulate the spontaneous development of tumors in their native tissue environment. Singh et al . establish their…”
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Disparities in cannabis use and documentation in electronic health records among children and young adults by Tavabi, Nazgol, Raza, Marium, Singh, Mallika, Golchin, Shahriar, Singh, Harsev, Hogue, Grant D., Kiapour, Ata M.

“…The legalizations of medical and recreational cannabis have generated a great deal of interest in studying the health impacts of cannabis products. Despite…”
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Proapoptotic Activation of Death Receptor 5 on Tumor Endothelial Cells Disrupts the Vasculature and Reduces Tumor Growth by Wilson, Nicholas S., Yang, Annie, Yang, Becky, Couto, Suzana, Stern, Howard, Gogineni, Alvin, Pitti, Robert, Marsters, Scot, Weimer, Robby M., Singh, Mallika, Ashkenazi, Avi

“…The proapoptotic death receptor DR5 has been studied extensively in cancer cells, but its action in the tumor microenvironment is not well defined. Here, we…”
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Efficacy of a Novel Bi-Steric mTORC1 Inhibitor in Models of B-Cell Acute Lymphoblastic Leukemia by Lee, Bianca J., Mallya, Sharmila, Dinglasan, Nuntana, Fung, Amos, Nguyen, Tram, Herzog, Lee-or, Thao, Joshua, Lorenzana, Edward G., Wildes, David, Singh, Mallika, Smith, Jacqueline A. M., Fruman, David A.

“…The mechanistic target of rapamycin (mTOR) is a kinase whose activity is elevated in hematological malignancies. mTOR-complex-1 (mTORC1) phosphorylates…”
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Modeling targeted inhibition of MEK and PI3 kinase in human pancreatic cancer by Junttila, Melissa R, Devasthali, Vidusha, Cheng, Jason H, Castillo, Joseph, Metcalfe, Ciara, Clermont, Anne C, Otter, Douglas Den, Chan, Emily, Bou-Reslan, Hani, Cao, Tim, Forrest, William, Nannini, Michelle A, French, Dorothy, Carano, Richard, Merchant, Mark, Hoeflich, Klaus P, Singh, Mallika

“…Activating mutations in the KRAS oncogene occur in approximately 90% of pancreatic cancers, resulting in aberrant activation of the MAPK and the PI3K pathways,…”
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Mutator suppression and escape from replication error-induced extinction in yeast by Herr, Alan J, Ogawa, Masanori, Lawrence, Nicole A, Williams, Lindsey N, Eggington, Julie M, Singh, Mallika, Smith, Robert A, Preston, Bradley D

“…Cells rely on a network of conserved pathways to govern DNA replication fidelity. Loss of polymerase proofreading or mismatch repair elevates spontaneous…”
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Crystal Structure of BMP-9 and Functional Interactions with Pro-region and Receptors by Brown, Monica A., Zhao, Qinghai, Baker, Kent A., Naik, Chethana, Chen, Cecil, Pukac, Laurie, Singh, Mallika, Tsareva, Tatiana, Parice, Yanick, Mahoney, Angela, Roschke, Viktor, Sanyal, Indra, Choe, Senyon

“…Bone morphogenetic proteins (BMPs), a subset of the transforming growth factor (TGF)-β superfamily, regulate a diverse array of cellular functions during…”
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Abstract IA-04: Targeting the oncogenic state of RAS with tri-complex inhibitors by Singh, Mallika

“…Abstract KRAS oncogenic driver mutations occur in approximately 30% of all human cancers, and in particular, in over 90% of patients with pancreatic ductal…”
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