Search Results - "Singh, Krishna B"

RNA-seq reveals novel mechanistic targets of withaferin A in prostate cancer cells by Kim, Su-Hyeong, Hahm, Eun-Ryeong, Singh, Krishna B, Shiva, Sruti, Stewart-Ornstein, Jacob, Singh, Shivendra V

“…Withaferin A (WA) is a promising phytochemical exhibiting in vitro and in vivo anticancer activities against prostate and other cancers, but the mechanism of…”
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Therapeutic Potential of Leelamine, a Novel Inhibitor of Androgen Receptor and Castration-Resistant Prostate Cancer by Singh, Krishna B, Ji, Xinhua, Singh, Shivendra V

“…Clinical management of castration-resistant prostate cancer (CRPC) resulting from androgen deprivation therapy remains challenging. CRPC is driven by aberrant…”
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Leelamine Is a Novel Lipogenesis Inhibitor in Prostate Cancer Cells In Vitro and In Vivo by Singh, Krishna B, Hahm, Eun-Ryeong, Pore, Subrata K, Singh, Shivendra V

“…Increased synthesis of fatty acids is implicated in the pathogenesis of human prostate cancer, but a safe and effective clinical inhibitor of this metabolic…”
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Mitochondrial Dysfunction in Cancer Chemoprevention by Phytochemicals from Dietary and Medicinal Plants by Sehrawat, Anuradha, Roy, Ruchi, Pore, Subrata K, Hahm, Eun-Ryeong, Samanta, Suman K, Singh, Krishna B, Kim, Su-Hyeong, Singh, Kamayani, Singh, Shivendra V

“…Abstract Cancer chemoprevention, a scientific term coined by Dr. Sporn in the late seventies, implies use of natural or synthetic chemicals to block, delay or…”
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Fatty Acid Synthesis Intermediates Represent Novel Noninvasive Biomarkers of Prostate Cancer Chemoprevention by Phenethyl Isothiocyanate by Singh, Krishna B, Singh, Shivendra V

“…Increased synthesis of fatty acids is a distinctive feature of prostate cancer, which continues to be a leading cause of cancer-related deaths among American…”
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Diallyl Trisulfide Inhibits Leptin-induced Oncogenic Signaling in Human Breast Cancer Cells but Fails to Prevent Chemically-induced Luminal-type Cancer in Rats by Kim, Su-Hyeong, Hahm, Eun-Ryeong, Singh, Krishna B, Singh, Shivendra V

“…Previous studies have demonstrated inhibitory effect of garlic component diallyl trisulfide (DATS) on growth of breast cancer cells in vitro and in vivo. This…”
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Withania somnifera root extract inhibits fatty acid synthesis in prostate cancer cells by Kim, Su-Hyeong, Singh, Krishna B., Hahm, Eun-Ryeong, Lokeshwar, Balakrishna L., Singh, Shivendra V.

“…Prior research argues for a role of increased de novo fatty acid synthesis in pathogenesis of prostate adenocarcinoma, which remains a leading cause of…”
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A novel metabolic function of Myc in regulation of fatty acid synthesis in prostate cancer by Singh, Krishna B., Hahm, Eun-Ryeong, Kim, Su-Hyeong, Wendell, Stacy G., Singh, Shivendra V.

“…A subset of human prostate cancer exhibits increased de novo synthesis of fatty acids, but the molecular driver(s) of this metabolic abnormality remains…”
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Prostate cancer chemoprevention by sulforaphane in a preclinical mouse model is associated with inhibition of fatty acid metabolism by Singh, Krishna B, Kim, Su-Hyeong, Hahm, Eun-Ryeong, Pore, Subrata K, Jacobs, Bruce L, Singh, Shivendra V

“…Increased fatty acid synthesis is a rather unique mechanism of prostate cancer. This study demonstrates, for the first time, that prostate cancer prevention by…”
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A Comprehensive Review and Perspective on Anticancer Mechanisms of Withaferin A in Breast Cancer by Hahm, Eun-Ryeong, Kim, Su-Hyeong, Singh, Krishna B, Singh, Kamayani, Singh, Shivendra V

“…Withaferin A (hereafter abbreviated as WA) is a promising anticancer steroidal lactone abundant in a medicinal plant ( ) native to Asia. The root/leaf extract…”
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Withaferin A Inhibits Fatty Acid Synthesis in Rat Mammary Tumors by Singh, Krishna B, Hahm, Eun-Ryeong, Kim, Su-Hyeong, Singh, Shivendra V

“…Withaferin A (WA), which is a small molecule derived from a medicinal plant (Withania somnifera), inhibits growth of human breast cancer xenografts and mammary…”
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The Role of Forkhead Box Q1 Transcription Factor in Anticancer Effects of Withaferin A in Breast Cancer by Kim, Su-Hyeong, Singh, Krishna B, Hahm, Eun-Ryeong, Singh, Shivendra V

“…Elimination of both rapidly dividing epithelial mammary cancer cells as well as breast cancer stem-like cells (bCSC) is essential for maximizing antitumor…”
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Reversal of the Warburg phenomenon in chemoprevention of prostate cancer by sulforaphane by Singh, Krishna B, Hahm, Eun-Ryeong, Alumkal, Joshi J, Foley, Lesley M, Hitchens, T Kevin, Shiva, Sruti S, Parikh, Rahul A, Jacobs, Bruce L, Singh, Shivendra V

“…Inhibition of metabolic re-programming represents an attractive approach for prevention of prostate cancer. Studies have implicated increased synthesis of…”
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RNA‐seq reveals novel cancer‐selective and disease subtype‐independent mechanistic targets of withaferin A in human breast cancer cells by Hahm, Eun‐Ryeong, Kim, Su‐Hyeong, Singh, Krishna B., Singh, Shivendra V.

“…Withaferin A (WA) exhibits cancer chemopreventive efficacy in preclinical models representative of two different subtypes of breast cancer. However, the…”
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Disease Subtype-Independent Biomarkers of Breast Cancer Chemoprevention by the Ayurvedic Medicine Phytochemical Withaferin A by Samanta, Suman K, Sehrawat, Anuradha, Kim, Su-Hyeong, Hahm, Eun-Ryeong, Shuai, Yongli, Roy, Ruchi, Pore, Subrata K, Singh, Krishna B, Christner, Susan M, Beumer, Jan H, Davidson, Nancy E, Singh, Shivendra V

“…A nontoxic chemopreventive intervention efficacious against different subtypes of breast cancer is still a clinically unmet need. The present study was…”
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Novel mechanistic targets of forkhead box Q1 transcription factor in human breast cancer cells by Kim, Su‐Hyeong, Hahm, Eun‐Ryeong, Singh, Krishna B., Singh, Shivendra V.

“…The transcription factor forkhead box Q1 (FoxQ1) is overexpressed in different solid tumors including breast cancer, but the mechanism underlying its oncogenic…”
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The Role of Lysosome-associated Membrane Protein 2 in Prostate Cancer Chemopreventive Mechanisms of Sulforaphane by Hahm, Eun-Ryeong, Singh, Krishna B, Kim, Su-Hyeong, Powolny, Anna A, Singh, Shivendra V

“…Prostate cancer chemoprevention by sulforaphane, which is a metabolic by-product of glucoraphanin found in broccoli, in preclinical models is associated with…”
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A Novel Sulforaphane-Regulated Gene Network in Suppression of Breast Cancer-Induced Osteolytic Bone Resorption by Pore, Subrata K, Hahm, Eun-Ryeong, Kim, Su-Hyeong, Singh, Krishna B, Nyiranshuti, Lea, Latoche, Joseph D, Anderson, Carolyn J, Adamik, Juraj, Galson, Deborah L, Weiss, Kurt R, Watters, Rebecca J, Lee, Boeun, Kumta, Prashant N, Singh, Shivendra V

“…Bone is the most preferred site for colonization of metastatic breast cancer cells for each subtype of the disease. The standard of therapeutic care for breast…”
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Inhibition of Glycolysis in Prostate Cancer Chemoprevention by Phenethyl Isothiocyanate by Singh, Krishna B, Hahm, Eun-Ryeong, Rigatti, Lora H, Normolle, Daniel P, Yuan, Jian-Min, Singh, Shivendra V

“…We have shown previously that dietary administration of phenethyl isothiocyanate (PEITC), a small molecule from edible cruciferous vegetables, significantly…”
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Persistent estrus rat models of polycystic ovary disease: an update by Singh, Krishna B

“…To critically review published articles on polycystic ovary (PCO) disease in rat models, with a focus on delineating its pathophysiology. Review of the…”
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