Search Results - "Singh, Erinprit K"

Synthesis of sansalvamide A peptidomimetics: triazole, oxazole, thiazole, and pseudoproline containing compounds by Davis, Melinda R., Singh, Erinprit K., Wahyudi, Hendra, Alexander, Leslie D., Kunicki, Joseph B., Nazarova, Lidia A., Fairweather, Kelly A., Giltrap, Andrew M., Jolliffe, Katrina A., McAlpine, Shelli R.

“…Peptidomimetic-based macrocycles typically have improved pharmacokinetic properties over those observed with peptide analogs. Described are the syntheses of 13…”
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Macrocyclic inhibitors of hsp90 by Johnson, Victoria A, Singh, Erinprit K, Nazarova, Lidia A, Alexander, Leslie D, McAlpine, Shelli R

“…Heat shock proteins (HSP) are a family of highly conserved proteins, whose expression increases in response to stresses that may threaten cell survival. Over…”
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Synthesis of Second-Generation Sansalvamide A Derivatives: Novel Templates as Potential Antitumor Agents by Rodriguez, Rodrigo A, Pan, Po-Shen, Pan, Chung-Mao, Ravula, Suchitra, Lapera, Stephanie, Singh, Erinprit K, Styers, Thomas J, Brown, Joseph D, Cajica, Julia, Parry, Emily, Otrubova, Katerina, McAlpine, Shelli R

“…We report the synthesis of 34 second-generation Sansalvamide A derivatives. San A derivatives have unique anticancer properties and target multiple cancers,…”
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Total Synthesis of trans,trans-Sanguinamide B and Conformational Isomers by Singh, Erinprit K, Ramsey, Deborah M, McAlpine, Shelli R

“…The first total synthesis of Sanguinamide B is reported, prepared via an efficient synthetic strategy. The natural product, trans,trans-Sanguinamide B (1), was…”
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Synthesis, Structure–Activity Analysis, and Biological Evaluation of Sanguinamide B Analogues by Wahyudi, Hendra, Tantisantisom, Worawan, Liu, Xuechao, Ramsey, Deborah M, Singh, Erinprit K, McAlpine, Shelli R

“…We report the first synthesis of sanguinamide B analogues. Substituting N-methylated (N-Me) amino acids, glycine (Gly), and l- or d-phenylalanine (Phe) into…”
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Design and synthesis of Hsp90 inhibitors: Exploring the SAR of Sansalvamide A derivatives by Sellers, Robert P., Alexander, Leslie D., Johnson, Victoria A., Lin, Chun-Chieh, Savage, Jeremiah, Corral, Ricardo, Moss, Jason, Slugocki, Tim S., Singh, Erinprit K., Davis, Melinda R., Ravula, Suchitra, Spicer, Jamie E., Oelrich, Jenna L., Thornquist, Andrea, Pan, Chung-Mao, McAlpine, Shelli R.

“…Utilizing the structure–activity relationship we have developed during the synthesis of the first two generations and mechanism of action studies that point to…”
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Histone deacetylase inhibitors: synthesis of cyclic tetrapeptides and their triazole analogs by Singh, Erinprit K., Nazarova, Lidia A., Lapera, Stephanie A., Alexander, Leslie D., McAlpine, Shelli R.

“…Synthesis of nine macrocyclic peptide HDAC inhibitors and three triazole derivatives is described. HDAC inhibitory activity of these compounds against HeLa…”
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Synthesis and biological evaluation of histone deacetylase inhibitors that are based on FR235222: A cyclic tetrapeptide scaffold by Singh, Erinprit K., Ravula, Suchitra, Pan, Chung-Mao, Pan, Po-Shen, Vasko, Robert C., Lapera, Stephanie A., Weerasinghe, Sujith V.W., Pflum, Mary Kay H., McAlpine, Shelli R.

“…We outline the synthesis of six novel derivatives that are based on a recently discovered HDAC inhibitor FR235222. Our work is the first report utilizing a…”
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Conformationally based design of macrocycles as antitumor agents by Singh, Erinprit K, Sellers, Robert P, Alexander, Leslie D, McAlpine, Shelli R

“…A key feature for any chemotherapeutic agent is a favorable conformation when it is presenting itself to its intended target. Numerous macrocycles have been…”
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Design and synthesis of bioactive macrocyclic natural products by Singh, Erinprit K

“…Chapter 1 discusses the background of peptides and their potential as therapeutics; specifically as anti-cancer and antibacterial agents. The synthesis of…”
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Design and synthesis of bioactive macrocyclic natural products by Singh, Erinprit K

“…Chapter 1 discusses the background of peptides and their potential as therapeutics; specifically as anti-cancer and antibacterial agents. The synthesis of…”
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