Search Results - "Singh, Carol M"

Development of a Highly Sensitive Neurofilament Light Chain Assay on an Automated Immunoassay Platform by Lee, Stephen, Plavina, Tatiana, Singh, Carol M., Xiong, Kuangnan, Qiu, Xiaolei, Rudick, Richard A., Calabresi, Peter A., Stevenson, Lauren, Graham, Danielle, Raitcheva, Denitza, Green, Christopher, Matias, Madeleine, Uzgiris, Arejas J.

“…Background Neurofilament light chain (NfL) is an axonal cytoskeletal protein that is released into the extracellular space following neuronal or axonal injury…”
Get full text

Associations of sNfL with clinico‐radiological measures in a large MS population by Sotirchos, Elias S., Fitzgerald, Kathryn C., Singh, Carol M., Smith, Matthew D., Reyes‐Mantilla, Maria, Hersh, Carrie M., Hyland, Megan H., Canissario, Ryan, Simmons, Sarah B., Arrambide, Georgina, Montalban, Xavier, Comabella, Manuel, Naismith, Robert T., Qiao, Min, Krupp, Lauren B., Nicholas, Jacqueline A., Akgün, Katja, Ziemssen, Tjalf, Rudick, Richard, Fisher, Elizabeth, Bermel, Robert A., Mowry, Ellen M., Calabresi, Peter A.

“…Objective Evaluation of serum neurofilament light chain (sNfL), measured using high‐throughput assays on widely accessible platforms in large, real‐world MS…”
Get full text

Ethanol Intoxication in Drosophila: Genetic and Pharmacological Evidence for Regulation by the cAMP Signaling Pathway by Moore, Monica S, DeZazzo, Jim, Luk, Alvin Y, Tully, Tim, Singh, Carol M, Heberlein, Ulrike

“…Upon exposure to ethanol, Drosophila display behaviors that are similar to ethanol intoxication in rodents and humans. Using an inebriometer to measure…”
Get full text

Neurofilament light levels are associated with long-term outcomes in multiple sclerosis by Kuhle, Jens, Plavina, Tatiana, Barro, Christian, Disanto, Giulio, Sangurdekar, Dipen, Singh, Carol M, de Moor, Carl, Engle, Bob, Kieseier, Bernd C, Fisher, Elizabeth, Kappos, Ludwig, Rudick, Richard A, Goyal, Jaya

“…Background: Neurofilament light chain (NfL) is a promising marker of disease activity/treatment response in multiple sclerosis (MS), although its predictive…”
Get full text

Serum neurofilament light levels in natalizumab-treated patients with multiple sclerosis who switch to extended interval dosing from every-4-week dosing in real-world clinical practice by Foley, John, Xiong, Kuangnan, Hoyt, Tammy, Singh, Carol M, Riddle, Evan, de Moor, Carl, Plavina, Tatiana, Campbell, Nolan

“…Background: Serum levels of neurofilament light chain (sNfL) are a potentially useful biomarker for assessing the efficacy of multiple sclerosis (MS)…”
Get full text

Temporal profile of serum neurofilament light in multiple sclerosis: Implications for patient monitoring by Calabresi, Peter A, Arnold, Douglas L, Sangurdekar, Dipen, Singh, Carol M, Altincatal, Arman, de Moor, Carl, Engle, Bob, Goyal, Jaya, Deykin, Aaron, Szak, Suzanne, Kieseier, Bernd C, Rudick, Richard A, Plavina, Tatiana

“…Objective: To understand how longitudinal serum neurofilament light chain (sNfL) patterns can inform its use as a prognostic biomarker in multiple sclerosis…”
Get full text

Temporal Relationship Between Serum Neurofilament Light Chain and Radiologic Disease Activity in Patients With Multiple Sclerosis by Fox, Robert J, Cree, Bruce A C, de Sèze, Jérôme, Gold, Ralf, Hartung, Hans-Peter, Jeffery, Douglas, Kappos, Ludwig, Montalban, Xavier, Weinstock-Guttman, Bianca, Singh, Carol M, Altincatal, Arman, Belviso, Nicholas, Avila, Robin L, Ho, Pei-Ran, Su, Ray, Engle, Robert, Sangurdekar, Dipen, de Moor, Carl, Fisher, Elizabeth, Kieseier, Bernd C, Rudick, Richard A

“…Serum neurofilament light chain (sNfL) levels correlate with multiple sclerosis (MS) disease activity, but the dynamics of this correlation are unknown. We…”
Get full text

Immunoglobulin G immune response to SARS-CoV-2 vaccination in people living with multiple sclerosis within Multiple Sclerosis Partners Advancing Technology and Health Solutions by Cohen, Jeffrey A, Bermel, Robert A, Grossman, Cynthia I, Hersh, Carrie M, Hyland, Megan, Mowry, Ellen M, Naismith, Robert, Naylor, Maria L, Nicholas, Jacqueline, Rajbhandar, Rajani, Singh, Carol M, Tintorè, Mar, Zabalza, Ana, Ziemssen, Tjalf, Williams, James R, Montalban, Xavier

“…Background: The impact of multiple sclerosis (MS) disease-modifying therapies (DMTs) on SARS-CoV-2 vaccination response is uncertain. Methods: Post-SARS-CoV-2…”
Get full text

Glial fibrillary acidic protein and multiple sclerosis progression independent of acute inflammation by Jiang, Xiaotong, Shen, Changyu, Teunissen, Charlotte E, Wessels, Mark, Zetterberg, Henrik, Giovannoni, Gavin, Singh, Carol M, Caba, Bastien, Elliott, Colm, Fisher, Elizabeth, de Moor, Carl, Belachew, Shibeshih, Gafson, Arie R

“…Background: The clinical relevance of serum glial fibrillary acidic protein (sGFAP) concentration as a biomarker of MS disability progression independent of…”
Get full text

Growth and differentiation in the Drosophila eye coordinated by hedgehog by Heberlein, Ulrike, Singh, Carol M, Luk, Alvin Y, Donohoe, Terrence J

“…Differentiation of the Drosophila retina is asynchronous: it starts at the posterior margin of the eye imaginal disc and progresses anteriorly over two days…”
Get full text

Association of Serum Neurofilament Light Levels With Long-term Brain Atrophy in Patients With a First Multiple Sclerosis Episode by Plavina, Tatiana, Singh, Carol M, Sangurdekar, Dipen, de Moor, Carl, Engle, Bob, Gafson, Arie, Goyal, Jaya, Fisher, Elizabeth, Szak, Suzanne, Kinkel, Revere P, Sandrock, Alfred W, Su, Ray, Kieseier, Bernd C, Rudick, Richard A

“…Data are needed on the potential long-term prognostic association of serum neurofilament light in multiple sclerosis (MS). To evaluate serum neurofilament…”
Get full text

Serum neurofilament light-chain levels and long-term treatment outcomes in relapsing-remitting multiple sclerosis patients: A post hoc analysis of the randomized CombiRx trial by Cutter, Gary, Rudick, Richard A, de Moor, Carl, Singh, Carol M, Fisher, Elizabeth, Koster, Thijs, Lublin, Fred D, Wolinsky, Jerry S, McFarland, Henry, Jacobson, Steven, Naylor, Maria L

“…Background CombiRx was a randomized, double-blind, placebo-controlled phase 3 trial in treatment-naive relapsing-remitting multiple sclerosis (RRMS) patients…”
Get full text

Genetic Control of Acute Ethanol-Induced Behaviors in Drosophila by Singh, Carol M., Heberlein, Ulrike

“…Background: In most organisms in which acute ethanol exposure has been studied, it leads to similar changes in behavior. Generally, low ethanol doses activate…”
Get full text

Modeling Alzheimer's disease in Drosophila melanogaster for large-scale compound screening by Mahoney, Matt B, Diggins, Lenard, Foos, Marianna, Lund, Emily, Mediatore, James, O'Neil, Phil, Symonds, Jim, Villaluz, Alfred T, Singh, Carol M

Get full text

Compound Screening In A Drosophila melanogaster Alzheimer's Disease Model Using A Behavioral Readout by Mahoney, Matt B, Singh, Carol M, Diggins, Lenard T, Keefe, Devin, Lund, Emily, O'Neil, Phil, Sigel, Eric, Symonds, Jim, Villaluz, Alfred, Ahlijanian, Michael K, Palfreyman, Michael G

Get full text

Serum neurofilament light-chain (sNfL) levels and long-term treatment outcomes in relapsing-remitting multiple sclerosis (RRMS) patients in the CombiRx trial (2410) by Cutter, Gary, Rudick, Richard A., De Moor, Carl, Singh, Carol M., Fisher, Elizabeth, Lublin, Fred D., Wolinsky, Jerry S., McFarland, Henry, Jacobson, Steven, Naylor, Maria L.

“…Abstract only…”
Get full text

Serum Neurofilament Light (sNfL) for Disease Prognosis and Treatment Monitoring in Multiple Sclerosis Patients:Towards Implementation into Clinical Care (S26.001) by Calabresi, Peter A., Kuhle, Jens, Arnold, Douglas L., Kinkel, R. Philip, Kappos, Ludwig, Singh, Carol M., Sangurdekar, Dipen, de Moor, Carl, Engle, Bob, Su, Ray, Deykin, Aaron, Fisher, Elizabeth, Sandrock, Alfred, Kieseier, Bernd C., Rudick, Richard A., Plavina, Tatiana

“…Abstract only…”
Get full text

Natalizumab Reduces Serum Concentrations of Neurofilament Light Chain in Secondary Progressive Multiple Sclerosis Patients From the Phase 3 ASCEND Study (S12.008) by Kapoor, Raju, Sellebjerg, Finn, Hartung, Hans-Peter, Arnold, Douglas, Freedman, Mark S., Jeffery, Douglas, Miller, Aaron, Edwards, Keith R., Singh, Carol M., Chang, Ih, Ren, Zhang, Sangurdekar, Dipen, Zhu, Bing, Mehta, Devangi, Ho, Pei-Ran, Campbell, Nolan, Edwards, Michael, Fisher, Elizabeth, Kieseier, Bernd C., Rudick, Richard A., Plavina, Tatiana

“…Abstract only…”
Get full text

A complementary transposon tool kit for Drosophila melanogaster using P and piggyBac by Thibault, Stephen T, Singer, Matthew A, Miyazaki, Wesley Y, Milash, Brett, Dompe, Nicholas A, Singh, Carol M, Buchholz, Ross, Demsky, Madelyn, Fawcett, Robert, Francis-Lang, Helen L, Ryner, Lisa, Cheung, Lai Man, Chong, Angela, Erickson, Cathy, Fisher, William W, Greer, Kimberly, Hartouni, Stephanie R, Howie, Elizabeth, Jakkula, Lakshmi, Joo, Daniel, Killpack, Keith, Laufer, Alex, Mazzotta, Julie, Smith, Ronald D, Stevens, Lynn M, Stuber, Christiana, Tan, Lory R, Ventura, Richard, Woo, Alesa, Zakrajsek, Irena, Zhao, Lora, Chen, Feng, Swimmer, Candace, Kopczynski, Casey, Duyk, Geoffrey, Winberg, Margaret L, Margolis, Jonathan

“…With the availability of complete genome sequence for Drosophila melanogaster, one of the next strategic goals for fly researchers is a complete gene knockout…”
Get full text

Functional Ethanol Tolerance in Drosophila by Scholz, Henrike, Ramond, Jennifer, Singh, Carol M., Heberlein, Ulrike

“…In humans, repeated alcohol consumption leads to the development of tolerance, manifested as a reduced physiological and behavioral response to a particular…”
Get full text