Search Results - "Singh, Bhairab N."

Generation of human endothelium in pig embryos deficient in ETV2 by Das, Satyabrata, Koyano-Nakagawa, Naoko, Gafni, Ohad, Maeng, Geunho, Singh, Bhairab N., Rasmussen, Tara, Pan, Xiaoyan, Choi, Kyung-Dal, Mickelson, Daniel, Gong, Wuming, Pota, Pruthvi, Weaver, Cyprian V., Kren, Stefan, Hanna, Jacob H., Yannopoulos, Demetris, Garry, Mary G., Garry, Daniel J.

“…The scarcity of donor organs may be addressed in the future by using pigs to grow humanized organs with lower potential for immunological rejection after…”
Get full text

A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human by Singh, Bhairab N., Koyano-Nakagawa, Naoko, Gong, Wuming, Moskowitz, Ivan P., Weaver, Cyprian V., Braunlin, Elizabeth, Das, Satyabrata, van Berlo, Jop H., Garry, Mary G., Garry, Daniel J.

“…The mammalian heart has a limited regenerative capacity and typically progresses to heart failure following injury. Here, we defined a hedgehog (HH)-Gli1-Mycn…”
Get full text

Dpath software reveals hierarchical haemato-endothelial lineages of Etv2 progenitors based on single-cell transcriptome analysis by Gong, Wuming, Rasmussen, Tara L., Singh, Bhairab N., Koyano-Nakagawa, Naoko, Pan, Wei, Garry, Daniel J.

“…Developmental, stem cell and cancer biologists are interested in the molecular definition of cellular differentiation. Although single-cell RNA sequencing…”
Get full text

Etv2 regulates enhancer chromatin status to initiate Shh expression in the limb bud by Koyano-Nakagawa, Naoko, Gong, Wuming, Das, Satyabrata, Theisen, Joshua W. M., Swanholm, Tran B., Van Ly, Daniel, Dsouza, Nikita, Singh, Bhairab N., Kawakami, Hiroko, Young, Samantha, Chen, Katherine Q., Kawakami, Yasuhiko, Garry, Daniel J.

“…Sonic hedgehog ( Shh ) is essential for limb development, and the mechanisms that govern the propagation and maintenance of its expression has been well…”
Get full text

Etv2-miR-130a-Jarid2 cascade regulates vascular patterning during embryogenesis by Singh, Bhairab N, Tahara, Naoyuki, Kawakami, Yasuhiko, Das, Satyabrata, Koyano-Nakagawa, Naoko, Gong, Wuming, Garry, Mary G, Garry, Daniel J

“…Remodeling of the primitive vasculature is necessary for the formation of a complex branched vascular architecture. However, the factors that modulate these…”
Get full text

Etv2 transcriptionally regulates Yes1 and promotes cell proliferation during embryogenesis by Singh, Bhairab N., Gong, Wuming, Das, Satyabrata, Theisen, Joshua W. M., Sierra-Pagan, Javier E., Yannopoulos, Demetris, Skie, Erik, Shah, Pruthvi, Garry, Mary G., Garry, Daniel J.

“…Etv2, an Ets-transcription factor, governs the specification of the earliest hemato-endothelial progenitors during embryogenesis. While the transcriptional…”
Get full text

The Etv2-miR-130a Network Regulates Mesodermal Specification by Singh, Bhairab N., Kawakami, Yasuhiko, Akiyama, Ryutaro, Rasmussen, Tara L., Garry, Mary G., Gong, Wuming, Das, Satyabrata, Shi, Xiaozhong, Koyano-Nakagawa, Naoko, Garry, Daniel J.

“…MicroRNAs (miRNAs) are known to regulate critical developmental stages during embryogenesis. Here, we defined an Etv2-miR-130a cascade that regulates…”
Get full text

Myosin Heavy Chain Converter Domain Mutations Drive Early-Stage Changes in Extracellular Matrix Dynamics in Hypertrophic Cardiomyopathy by Hsieh, Jeanne, Becklin, Kelsie L., Givens, Sophie, Komosa, Elizabeth R., Lloréns, Juan E. Abrahante, Kamdar, Forum, Moriarity, Branden S., Webber, Beau R., Singh, Bhairab N., Ogle, Brenda M.

“…More than 60% of hypertrophic cardiomyopathy (HCM)-causing mutations are found in the gene loci encoding cardiac myosin-associated proteins including myosin…”
Get full text

Humanized skeletal muscle in MYF5/MYOD/MYF6-null pig embryos by Maeng, Geunho, Das, Satyabrata, Greising, Sarah M., Gong, Wuming, Singh, Bhairab N., Kren, Stefan, Mickelson, Daniel, Skie, Erik, Gafni, Ohad, Sorensen, Jacob R., Weaver, Cyprian V., Garry, Daniel J., Garry, Mary G.

Get full text

Proliferation and Maturation: Janus and the Art of Cardiac Tissue Engineering by Singh, Bhairab N., Yucel, Dogacan, Garay, Bayardo I., Tolkacheva, Elena G., Kyba, Michael, Perlingeiro, Rita C.R., van Berlo, Jop H., Ogle, Brenda M.

“…During cardiac development and morphogenesis, cardiac progenitor cells differentiate into cardiomyocytes that expand in number and size to generate the fully…”
Get full text

ETV2 (Ets Variant Transcription Factor 2)-Rhoj Cascade Regulates Endothelial Progenitor Cell Migration During Embryogenesis by Singh, Bhairab N., Sierra-Pagan, Javier E., Gong, Wuming, Das, Satyabrata, Theisen, Joshua W.M., Skie, Erik, Garry, Mary G., Garry, Daniel J.

“…OBJECTIVE:Endothelial progenitors migrate early during embryogenesis to form the primary vascular plexus. The regulatory mechanisms that govern their migration…”
Get full text

The HH-GLI2-CKS1B network regulates the proliferation-to-maturation transition of cardiomyocytes by Waldron, Christina J, Kelly, Lauren A, Stan, Nicholas, Kawakami, Yasuhiko, Abrahante, Juan E, Magli, Alessandro, Ogle, Brenda M, Singh, Bhairab N

“…Cardiomyocyte (CM) proliferation and maturation are highly linked processes, however, the extent to which these processes are controlled by a single signaling…”
Get full text

Hedgehog and Wnt coordinate signaling in myogenic progenitors and regulate limb regeneration by Singh, Bhairab N., Doyle, Michelle J., Weaver, Cyprian V., Koyano-Nakagawa, Naoko, Garry, Daniel J.

“…Amphibians have a remarkable capacity for limb regeneration. Following a severe injury, there is complete regeneration with restoration of the patterning and…”
Get full text

αB-crystallin, a small heat shock protein, modulates NF-κB activity in a phosphorylation-dependent manner and protects muscle myoblasts from TNF-α induced cytotoxicity by Adhikari, Amit S., Singh, Bhairab N., Rao, K. Sridhar, Rao, Ch Mohan

“…αB-crystallin, a member of the small heat shock protein family, has been implicated in various biological functions including response to heat shock,…”
Get full text

Humanized skeletal muscle in MYF5/MYOD/MYF6-null pig embryos by Maeng, Geunho, Das, Satyabrata, Greising, Sarah M., Gong, Wuming, Singh, Bhairab N., Kren, Stefan, Mickelson, Daniel, Skie, Erik, Gafni, Ohad, Sorensen, Jacob R., Weaver, Cyprian V., Garry, Daniel J., Garry, Mary G.

“…Because post-mortem human skeletal muscle is not viable, autologous muscle grafts are typically required in tissue reconstruction after muscle loss due to…”
Get full text

Hedgehog Signaling during Appendage Development and Regeneration by Singh, Bhairab N, Koyano-Nakagawa, Naoko, Donaldson, Andrew, Weaver, Cyprian V, Garry, Mary G, Garry, Daniel J

“…Regulatory networks that govern embryonic development have been well defined. While a common hypothesis supports the notion that the embryonic regulatory…”
Get full text

Heart of Newt: A Recipe for Regeneration by Singh, Bhairab N., Koyano-Nakagawa, Naoko, Garry, John P., Weaver, Cyprian V.

“…The field of regenerative medicine holds tremendous promise for the treatment of chronic diseases. While the adult mammalian heart has limited regenerative…”
Get full text

Abstract 19135: Shh-hippo Signaling Pathway Controls Cardiomyocyte Proliferation by Singh, Bhairab N

“…Abstract only In contrast to newts and zebrafish, the mammalian heart has limited regenerative potential. Defining the molecular cues controlling cardiac…”
Get full text

Abstract 19694: Etv2- Regulated Micrornas are Essential for Endothelial Development by Singh, Bhairab N

“…Abstract only Precise regulation of the fate of endothelial precursors is critical for vascular development. Currently, no known microRNAs have been shown to…”
Get full text

Abstract 16812: ETV2-Rhoj Cascade Regulates Endothelial Progenitor Cell Migration During Embryogenesis by Sierra-Pagan, Javier, SINGH, BHAIRAB N, Gong, Wuming, Das, Satyabrata, Skie, Erik, Garry, Mary G, Garry, Daniel J

“…BackgroundEndothelial progenitors migrate early during embryogenesis to form the primary vascular plexus. ETV2, an Ets-transcription factor, governs the…”
Get full text