Search Results - "Singh, Amareshwar T K"

Biomimetic, synthetic HDL nanostructures for lymphoma by Yang, Shuo, Damlano, Marina G., Zhang, Heng, Tripathy, Sushant, Luthi, Andrea J., Rink, Jonathan S., Ugolkov, Andrey V., Singh, Amareshwar T. K., Dave, Sandeep S., Gordon, Leo I., Thaxton, C. Shad

“…New therapies that challenge existing paradigms are needed for the treatment of cancer. We report a nanoparticle-enabled therapeutic approach to B-cell…”
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Apoptosis: A Target for Anticancer Therapy by Pfeffer, Claire M, Singh, Amareshwar T K

“…Apoptosis, the cell's natural mechanism for death, is a promising target for anticancer therapy. Both the intrinsic and extrinsic pathways use caspases to…”
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Mitochondrial-Mediated Apoptosis in Lymphoma Cells by the Diterpenoid Lactone Andrographolide, the Active Component of Andrographis paniculata by SHUO YANG, EVENS, Andrew M, PRACHAND, Sheila, SINGH, Amareshwar T. K, BHALLA, Savita, DAVID, Kevin, GORDON, Leo I

“…Andrographolide is a diterpenoid lactone isolated from Andrographis paniculata (King of Bitters), an herbal medicine used in Asia. It has been reported to have…”
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Cell-cycle Checkpoints and Aneuploidy on the Path to Cancer by Wenzel, Elizabeth S, Singh, Amareshwar T K

“…The cell cycle is a complex sequence of events through which a cell duplicates its contents and divides, and involves many regulatory proteins for proper…”
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All trans retinoic acid nanodisks enhance retinoic acid receptor mediated apoptosis and cell cycle arrest in mantle cell lymphoma by Singh, Amareshwar T.K., Evens, Andrew M., Anderson, Reilly J., Beckstead, Jennifer A., Sankar, Natesan, Sassano, Antonella, Bhalla, Savita, Yang, Shuo, Platanias, Leonidas C., Forte, Trudy M., Ryan, Robert O., Gordon, Leo I.

“…Summary Mantle cell lymphoma (MCL) is characterized by translocation t(11;14)(q13;q32), aggressive clinical behaviour, and poor patient outcomes following…”
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Hypoxia inducible factor‐alpha activation in lymphoma and relationship to the thioredoxin family by Evens, Andrew M., Schumacker, Paul T., Helenowski, Irene B., Singh, Amareshwar T. K., Dokic, Danijela, Keswani, Anjeni, Kordeluk, Elizabeth, Raji, Adekunle, Winter, Jane N., Jovanovic, Borko D., Holmgren, Arne, Nelson, Beverly P., Gordon, Leo I.

“…Summary Hypoxia inducible factors (HIFs) activate oncogenic pathways, while thioredoxins (Trx), including Trx1 and Trx reductases‐1 and ‐2 (TrxR1 and TrxR2),…”
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Blockade of the erbB2 Receptor Induces Cardiomyocyte Death through Mitochondrial and Reactive Oxygen Species-dependent Pathways by Gordon, Leo I., Burke, Michael A., Singh, Amareshwar T.K., Prachand, Sheila, Lieberman, Elliot D., Sun, Lin, Naik, Tejaswitha Jairaj, Prasad, Sathyamangla V. Naga, Ardehali, Hossein

“…Overexpression of the receptor tyrosine kinase erbB2 (Her2 in humans) is correlated with a poor prognosis in breast and ovarian cancers. Treatment with…”
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Curcumin nanodisks: formulation and characterization by Ghosh, Mistuni, MS, Singh, Amareshwar T.K., PhD, Xu, Wenwei, MS, Sulchek, Todd, PhD, Gordon, Leo I., MD, Ryan, Robert O., PhD

“…Abstract Nanodisks (NDs) are nanoscale, disk-shaped phospholipid bilayers whose edge is stabilized by apolipoproteins. In the present study, NDs were…”
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Novel Nanoscale Delivery Particles Encapsulated with Anticancer Drugs, All-trans Retinoic Acid or Curcumin, Enhance Apoptosis in Lymphoma Cells Predominantly Expressing CD20 Antigen by Stauffer, Richard G, Mohammad, Manar, Singh, Amareshwar T K

“…Mantle cell lymphoma (MCL), a B-cell lymphoma, pursues a relatively aggressive course, is resistant to long-term remission, and is associated with a poor…”
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Update on Nanotechnology-based Drug Delivery Systems in Cancer Treatment by Ho, Benjamin N, Pfeffer, Claire M, Singh, Amareshwar T K

“…The emerging field of nanotechnology meets the demands for innovative approaches in the diagnosis and treatment of cancer. The nanoparticles are biocompatible…”
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Glutathione depletion enhances arsenic trioxide‐induced apoptosis in lymphoma cells through mitochondrial‐independent mechanisms by Bhalla, Savita, Gordon, Leo I., David, Kevin, Prachand, Sheila, Singh, Amareshwar T.K., Yang, Shuo, Winter, Jane N., Guo, Dongsheng, O’Halloran, Thomas, Platanias, Leonidas C., Evens, Andrew M.

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Motexafin Gadolinium Enhances p53-Mdm2 Interactions, Reducing p53 and Downstream Targets in Lymphoma Cell Lines by SINGH, Amareshwar T. K, EVENS, Andrew M, PRACHAND, Sheila N, GORDON, Leo I

“…Loss of p53 renders cells more susceptible to acute oxidant stress induced by oxidant-generating agents such as motexafin gadolinium (MGd). We hypothesized…”
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The Evolution, Functions and Applications of the Breast Cancer Genes BRCA1 and BRCA2 by Pfeffer, Claire M, Ho, Benjamin N, Singh, Amareshwar T K

“…BRCA1 and BRCA2 are both tumor suppressors whose mutations are the cause of most hereditary breast cancers. Both genes are highly involved in ensuring genome…”
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Parathyroid hormone stimulates phosphatidylethanolamine hydrolysis by phospholipase D in osteoblastic cells by Singh, Amareshwar T. K., Frohman, Michael A., Stern, Paula H.

“…Parathyroid hormone (PTH) and phorbol‐12,13‐dibutyrate (PDBu) stimulate phospholipase D (PLD) activity and PC hydrolysis in UMR‐106 osteoblastic cells {Singh,…”
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Curcumin nanodisk-induced apoptosis in mantle cell lymphoma by Singh, Amareshwar T. K., Ghosh, Mistuni, Forte, Trudy M., Ryan, Robert O., Gordon, Leo I.

“…Mantle cell lymphoma (MCL) is a pre-germinal center neoplasm characterized by cyclin D1 overexpression resulting from t(11;14)(q13;q32). Since MCL is incurable…”
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Regulation of Parathyroid Hormone‐Stimulated Phospholipase D in UMR‐106 Cells by Calcium, MAP Kinase, and Small G Proteins by Singh, Amareshwar TK, Bhattacharyya, Rumi S, Radeff, Julie M, Stern, Paula H

“…Signaling intermediates for PTH and phorbol activation of PLD in UMR‐106 cells were determined. Calcium was required, and the effects of PTH, phorbol, and…”
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Parathyroid Hormone (PTH)-(1–34),[ Nle8,18,Tyr34]PTH-(3–34) Amide, PTH-(1–31) Amide, and PTH-Related Peptide-(1–34) Stimulate Phosphatidylcholine Hydrolysis in UMR-106 Osteoblastic Cells: Comparison with Effects of Phorbol 12,13-DibutyrateThis work was supported by NIH Grant AR-11262 (to P.H.S.). A portion of this study was presented at the 1997 Annual Meeting of American Society for Bone and Mineral Research, Cincinnati, OH by Singh, Amareshwar T K, Kunnel, Joseph G, Strieleman, Paul J, Stern, Paula H

“…Studies were performed to determine the effects of PTH and related compounds on phosphatidylcholine (PC) hydrolysis in UMR-106 cells and the pathway by which…”
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Serum ceruloplasmin in acute myocardial infarction by Singh, T K

“…Serum ceruloplasmin levels were estimated in 81 patients within one week after an attack of acute myocardial infarction. A total of 126 healthy subjects were…”
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A turbidimetric assay of lipid transfer activity by Singh, T K, Blacklock, B J, Wientzek, M, Ryan, R O

“…A novel method to assay insect plasma lipid transfer particle (LTP) activity has been developed that employs insect high density lipophorin (HDLp) and human…”
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Role of protein kinase A, phospholipase C and phospholipase D in parathyroid hormone receptor regulation of protein kinase Calpha and interleukin-6 in UMR-106 osteoblastic cells by Radeff, Julie M, Singh, Amareshwar T K, Stern, Paula H

“…Parathyroid hormone (PTH) stimulates both bone formation and resorption by activating diverse osteoblast signalling pathways. Upstream signalling for PTH…”
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