Search Results - "Singers Sørensen, Brita"

Tumor Hypoxia: Impact on Radiation Therapy and Molecular Pathways by Sørensen, Brita Singers, Horsman, Michael R

“…Tumor hypoxia is a common feature of the microenvironment in solid tumors, primarily due to an inadequate, and heterogeneous vascular network. It is associated…”
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In vivo validation and tissue sparing factor for acute damage of pencil beam scanning proton FLASH by Singers Sørensen, Brita, Krzysztof Sitarz, Mateusz, Ankjærgaard, Christina, Johansen, Jacob, Andersen, Claus E, Kanouta, Eleni, Overgaard, Cathrine, Grau, Cai, Poulsen, Per

“…•Setup for experimental in vivo validation of pencil beam scanning proton FLASH.•Full dose response curves of skin toxicity with FLASH vs conventional dose…”
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Relative biological effectiveness (RBE) and distal edge effects of proton radiation on early damage in vivo by Sørensen, Brita Singers, Bassler, Niels, Nielsen, Steffen, Horsman, Michael R, Grzanka, Leszek, Spejlborg, Harald, Swakoń, Jan, Olko, Paweł, Overgaard, Jens

“…The aim of the present study was to examine the RBE for early damage in an in vivo mouse model, and the effect of the increased linear energy transfer (LET)…”
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Overview of research and therapy facilities for radiobiological experimental work in particle therapy. Report from the European Particle Therapy Network radiobiology group by Dosanjh, Manjit, Jones, Bleddyn, Pawelke, Jörg, Pruschy, Martin, Sørensen, Brita Singers

“…Particle therapy (PT) as cancer treatment, using protons or heavier ions, can provide a more favorable dose distribution compared to X-rays. While the physical…”
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Evaluation of in vitro irradiation setup: Designed for the horizontal beamline at the Danish Centre for Particle Therapy by Frederiksen, Anders Tobias, Jensen, Morten Bjørn, Poulsen, Per Rugaard, Bassler, Niels, Sørensen, Brita Singers, Sitarz, Mateusz

“…Radiobiological experimental setups are challenged by precise sample positioning along depth dose profile, scattering conditions, and practical difficulties…”
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Comparison of Coding Transcriptomes in Fibroblasts Irradiated With Low and High LET Proton Beams and Cobalt-60 Photons by Nielsen, Steffen, Bassler, Niels, Grzanka, Leszek, Laursen, Louise, Swakon, Jan, Olko, Pawel, Andreassen, Christian Nicolaj, Alsner, Jan, Singers Sørensen, Brita

“…To identify differential cellular responses after proton and photon irradiation by comparing transcriptomes of primary fibroblasts irradiated with either…”
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Combination of proton- or X-irradiation with anti-PDL1 immunotherapy in two murine oral cancers by Rykkelid, Anne Marit, Sinha, Priyanshu Manojkumar, Folefac, Charlemagne Asonganyi, Horsman, Michael R., Sørensen, Brita Singers, Søland, Tine Merete, Schreurs, Olaf Joseph Franciscus, Malinen, Eirik, Edin, Nina Frederike J.

“…Combining radiation therapy with immunotherapy is a strategy to improve both treatments. The purpose of this study was to compare responses for two syngeneic…”
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Proton Compared to X-Irradiation Induces Different Protein Profiles in Oral Cancer Cells and Their Derived Extracellular Vesicles by Juvkam, Inga Solgård, Zlygosteva, Olga, Sitarz, Mateusz, Thiede, Bernd, Sørensen, Brita Singers, Malinen, Eirik, Edin, Nina Jeppesen, Søland, Tine Merete, Galtung, Hilde Kanli

“…Extracellular vesicles (EVs) are membrane-bound particles released from cells, and their cargo can alter the function of recipient cells. EVs from X-irradiated…”
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Differential gene expression in primary fibroblasts induced by proton and cobalt-60 beam irradiation by Nielsen, Steffen, Bassler, Niels, Grzanka, Leszek, Swakon, Jan, Olko, Pawel, Andreassen, Christian Nicolaj, Overgaard, Jens, Alsner, Jan, Sørensen, Brita Singers

“…Proton beam therapy delivers a more conformal dose distribution than conventional radiotherapy, thus improving normal tissue sparring. Increasing linear energy…”
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Spread-out Bragg peak FLASH: quantifying normal tissue toxicity in a murine model by Kristensen, Line, Poulsen, Per Rugaard, Kanouta, Eleni, Rohrer, Sky, Ankjærgaard, Christina, Andersen, Claus E, Johansen, Jacob G, Simeonov, Yuri, Weber, Uli, Grau, Cai, Sørensen, Brita Singers

“…A favorable effect of ultra-high dose rate (FLASH) radiation on normal tissue-sparing has been indicated in several preclinical studies. In these studies, the…”
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Optimal reference genes for normalization of qPCR gene expression data from proton and photon irradiated dermal fibroblasts by Nielsen, Steffen, Bassler, Niels, Grzanka, Leszek, Swakon, Jan, Olko, Pawel, Andreassen, Christian Nicolaj, Alsner, Jan, Sørensen, Brita Singers

“…The transcriptional response of cells exposed to proton radiation is not equivalent to the response induced by traditional photon beams. Changes in cellular…”
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Simultaneous Hypoxia and Low Extracellular pH Suppress Overall Metabolic Rate and Protein Synthesis In Vitro by Sørensen, Brita Singers, Busk, Morten, Overgaard, Jens, Horsman, Michael R, Alsner, Jan

“…The tumor microenvironment is characterized by regions of hypoxia and acidosis which are linked to poor prognosis. This occurs due to an aberrant vasculature…”
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Circulating cell-free DNA as predictor of pathological complete response in locally advanced rectal cancer patients undergoing preoperative chemoradiotherapy by Truelsen, Christina Glismand, Kronborg, Camilla Skovhus, Sørensen, Brita Singers, Callesen, Louise Bach, Spindler, Karen-Lise Garm

“…•cfDNA could be a biomarker for tailored follow-up in locally advanced rectal cancer.•Circulating cell-free DNA can be quantified by a rapid, and feasible DFA…”
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Associations between skin rash, treatment outcome, and single nucleotide polymorphisms in head and neck cancer patients receiving the EGFR-inhibitor zalutumumab: results from the DAHANCA 19 trial by Brøndum, Line, Alsner, Jan, Sørensen, Brita Singers, Maare, Christian, Johansen, Jørgen, Primdahl, Hanne, Evensen, Jan Folkvard, Kristensen, Claus Andrup, Andersen, Lisbeth Juhler, Overgaard, Jens, Eriksen, Jesper Grau

“…To study the associations between development of moderate to severe skin rash, clinical outcome, and single nucleotide polymorphisms (SNPs) in candidate genes…”
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A community call for a dedicated radiobiological research facility to support particle beam cancer therapy by Holzscheiter, Michael H, Bassler, Niels, Dosanjh, Manjit, Sørensen, Brita Singers, Overgaard, Jens

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Gene expression classifier predicts for hypoxic modification of radiotherapy with nimorazole in squamous cell carcinomas of the head and neck by Toustrup, Kasper, Sørensen, Brita Singers, Lassen, Pernille, Wiuf, Carsten, Alsner, Jan, Overgaard, Jens

“…Abstract Purpose To validate the predictive impact of a hypoxia gene expression classifier in identifying patients with head and neck squamous cell carcinoma…”
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Proteins upregulated by mild and severe hypoxia in squamous cell carcinomas in vitro identified by proteomics by Sørensen, Brita Singers, Horsman, Michael R, Vorum, Henrik, Honoré, Bent, Overgaard, Jens, Alsner, Jan

“…Abstract Background Solid malignant tumours are characterised by an inadequate vascular system, which can give rise to micro-regional hypoxic areas. As the…”
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Time‐resolved dose rate measurements in pencil beam scanning proton FLASH therapy with a fiber‐coupled scintillator detector system by Kanouta, Eleni, Poulsen, Per Rugaard, Kertzscher, Gustavo, Sitarz, Mateusz Krzysztof, Sørensen, Brita Singers, Johansen, Jacob Graversen

“…Background The spatial and temporal dose rate distribution of pencil beam scanning (PBS) proton therapy is important in ultra‐high dose rate (UHDR) or FLASH…”
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Clinical use and future requirements of relative biological effectiveness: Survey among all European proton therapy centres by Heuchel, Lena, Hahn, Christian, Pawelke, Jörg, Sørensen, Brita Singers, Dosanjh, Manjit, Lühr, Armin

“…•All European proton therapy centres reported on their clinical RBE considerations.•For most proton centres, variable RBE is a serious concern.•All prescribe a…”
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Time structure of pencil beam scanning proton FLASH beams measured with scintillator detectors and compared with log files by Kanouta, Eleni, Johansen, Jacob Graversen, Kertzscher, Gustavo, Sitarz, Mateusz Krzysztof, Sørensen, Brita Singers, Poulsen, Per Rugaard

“…Purpose Key factors in FLASH treatments are the ultra‐high dose rate (UHDR) and the time structure of the beam delivery. Measurement of the time structure in…”
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