Corneal Sensation After Topical Anesthesia

PURPOSE.To compare the topical effects of tetracaine, lidocaine, and bupivacaine on corneal sensitivity in normal eyes. METHODS.Corneal touch sensitivity was measured with a Cochet-Bonnet anesthesiometer before and at 2.5-minute intervals after instillation of the anesthetic agent, until baseline le...

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Bibliographic Details
Published in:	Cornea Vol. 20; no. 2; pp. 191 - 193
Main Authors:	Nomura, Keiko, Singer, Diane E, Aquavella, James V
Format:	Journal Article
Language:	English
Published:	United States Lippincott Williams & Wilkins, Inc 01-03-2001
Subjects:	Adult Anesthesia, Local - methods Anesthetics, Local - administration & dosage Bupivacaine - administration & dosage Cornea - drug effects Cornea - physiology Female Humans Lidocaine - administration & dosage Male Monitoring, Physiologic - instrumentation Sensation - drug effects Sensation - physiology Tetracaine - administration & dosage
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Summary:	PURPOSE.To compare the topical effects of tetracaine, lidocaine, and bupivacaine on corneal sensitivity in normal eyes. METHODS.Corneal touch sensitivity was measured with a Cochet-Bonnet anesthesiometer before and at 2.5-minute intervals after instillation of the anesthetic agent, until baseline levels had been reestablished. Seventeen healthy volunteers were randomized into five groups. Group 1 included 0.5% tetracaine (n = 6); group 2, 4% lidocaine (n = 8); group 3, 0.75% bupivacaine (n = 8); group 4, 0.5% tetracaine + 4% lidocaine (n = 5); and group 5, 0.5% tetracaine + 0.75% bupivacaine (n = 7). RESULTS.The duration of anesthesia showed no differences between groups 1, 3, and 5. Although there was no difference between groups 2 and 4, both groups demonstrated significantly longer effects than groups 1, 3, and 5 (p < 0.005). CONCLUSION.The application of 4% lidocaine results in a significantly prolonged topical anesthetic effect when compared with tetracaine and bupivacaine.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-News-3 content type line 23
ISSN:	0277-3740 1536-4798
DOI:	10.1097/00003226-200103000-00017