Search Results - "Singer, Benjamin H"

The Collision of Meta-Inflammation and SARS-CoV-2 Pandemic Infection by Huizinga, Gabrielle P, Singer, Benjamin H, Singer, Kanakadurga

“…Abstract The coronavirus disease 2019 (COVID-19) pandemic has forced us to consider the physiologic role of obesity in the response to infectious disease…”
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Sepsis and Nosocomial Infection: Patient Characteristics, Mechanisms, and Modulation by Denstaedt, Scott J, Singer, Benjamin H, Standiford, Theodore J

“…Sepsis is a leading cause of death worldwide. After initial trials modulating the hyperinflammatory phase of sepsis failed, generations of researchers have…”
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Cecal Ligation and Puncture Results in Long-Term Central Nervous System Myeloid Inflammation by Singer, Benjamin H, Newstead, Michael W, Zeng, Xianying, Cooke, Christopher L, Thompson, Robert C, Singer, Kanakadurga, Ghantasala, Ramya, Parent, Jack M, Murphy, Geoffrey G, Iwashyna, Theodore J, Standiford, Theodore J

“…Survivors of sepsis often experience long-term cognitive and functional decline. Previous studies utilizing lipopolysaccharide injection and cecal ligation and…”
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Bacterial Dissemination to the Brain in Sepsis by Singer, Benjamin H, Dickson, Robert P, Denstaedt, Scott J, Newstead, Michael W, Kim, Kwi, Falkowski, Nicole R, Erb-Downward, John R, Schmidt, Thomas M, Huffnagle, Gary B, Standiford, Theodore J

“…Sepsis causes brain dysfunction and neuroinflammation. It is unknown whether neuroinflammation in sepsis is initiated by dissemination of bacteria to the brain…”
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A digital protein microarray for COVID-19 cytokine storm monitoring by Song, Yujing, Ye, Yuxuan, Su, Shiuan-Haur, Stephens, Andrew, Cai, Tao, Chung, Meng-Ting, Han, Meilan K, Newstead, Michael W, Yessayan, Lenar, Frame, David, Humes, H David, Singer, Benjamin H, Kurabayashi, Katsuo

“…Despite widespread concern regarding cytokine storms leading to severe morbidity in COVID-19, rapid cytokine assays are not routinely available for monitoring…”
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S100A8/A9 Drives Neuroinflammatory Priming and Protects against Anxiety-like Behavior after Sepsis by Denstaedt, Scott J, Spencer-Segal, Joanna L, Newstead, Michael W, Laborc, Klaudia, Zhao, Anne P, Hjelmaas, Alexander, Zeng, Xianying, Akil, Huda, Standiford, Theodore J, Singer, Benjamin H

“…Sepsis commonly results in acute and chronic brain dysfunction, which dramatically increases the morbidity associated with this common disease. Chronic brain…”
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Persistent Neuroinflammation and Brain-Specific Immune Priming in a Novel Survival Model of Murine Pneumosepsis by Denstaedt, Scott J., Spencer-Segal, Joanna L., Newstead, Michael, Laborc, Klaudia, Zeng, Xianying, Standiford, Theodore J., Singer, Benjamin H.

“…ABSTRACTPneumonia is the leading cause of sepsis and septic shock. Patients who survive pneumonia are vulnerable to long-term complications including increased…”
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The relationship between adiposity and bone density in U.S. children and adolescents by Gállego Suárez, Cecilia, Singer, Benjamin H, Gebremariam, Achamyeleh, Lee, Joyce M, Singer, Kanakadurga

“…In adults, obesity has been associated with several health outcomes including increased bone density. Our objective was to evaluate the association between…”
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The Modular µSiM: A Mass Produced, Rapidly Assembled, and Reconfigurable Platform for the Study of Barrier Tissue Models In Vitro by McCloskey, Molly C., Kasap, Pelin, Ahmad, S. Danial, Su, Shiuan‐Haur, Chen, Kaihua, Mansouri, Mehran, Ramesh, Natalie, Nishihara, Hideaki, Belyaev, Yury, Abhyankar, Vinay V., Begolo, Stefano, Singer, Benjamin H., Webb, Kevin F., Kurabayashi, Katsuo, Flax, Jonathan, Waugh, Richard E., Engelhardt, Britta, McGrath, James L.

“…Advanced in vitro tissue chip models can reduce and replace animal experimentation and may eventually support “on‐chip” clinical trials. To realize this…”
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Compensatory network changes in the dentate gyrus restore long-term potentiation following ablation of neurogenesis in young-adult mice by Singer, Benjamin H, Gamelli, Amy E, Fuller, Cynthia L, Temme, Stephanie J, Parent, Jack M, Murphy, Geoffrey G

“…It is now well established that neurogenesis in the rodent subgranular zone of the hippocampal dentate gyrus continues throughout adulthood. Neuroblasts born…”
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CSF H3F3A K27M circulating tumor DNA copy number quantifies tumor growth and in vitro treatment response by Stallard, Stefanie, Savelieff, Masha G, Wierzbicki, Kyle, Mullan, Brendan, Miklja, Zachary, Bruzek, Amy, Garcia, Taylor, Siada, Ruby, Anderson, Bailey, Singer, Benjamin H, Hashizume, Rintaro, Carcaboso, Angel M, McMurray, Kaitlin Q, Heth, Jason, Muraszko, Karin, Robertson, Patricia L, Mody, Rajen, Venneti, Sriram, Garton, Hugh, Koschmann, Carl

“…[...]less invasive and more rapid diagnostic tests are needed to detect actionable brain cancer mutations. H3K27M detection in CSF by a combination of nested…”
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Alternative topical anesthesia for bronchoscopy in a case of severe lidocaine allergy by Hensley, Matthew, Singer, Benjamin H.

“…Lidocaine allergy presents a unique difficulty for both patients and providers who undergo/perform bronchoscopy. We present a case of a 73 yo male with severe…”
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The vasculature in sepsis: delivering poison or remedy to the brain? by Singer, Benjamin H

“…Survivors of sepsis and other forms of critical illness frequently experience significant and disabling cognitive and affective disorders. Inflammation,…”
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Conditional ablation and recovery of forebrain neurogenesis in the mouse by Singer, Benjamin H., Jutkiewicz, Emily M., Fuller, Cynthia L., Lichtenwalner, Robin J., Zhang, Helen, Velander, Alan J., Li, Xiangquan, Gnegy, Margaret E., Burant, Charles F., Parent, Jack M.

“…Forebrain neurogenesis persists throughout life in the rodent subventricular zone (SVZ) and hippocampal dentate gyrus (DG). Several strategies have been…”
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Machine-Learning-Assisted Microfluidic Nanoplasmonic Digital Immunoassay for Cytokine Storm Profiling in COVID-19 Patients by Gao, Zhuangqiang, Song, Yujing, Hsiao, Te Yi, He, Jiacheng, Wang, Chuanyu, Shen, Jialiang, MacLachlan, Alana, Dai, Siyuan, Singer, Benjamin H, Kurabayashi, Katsuo, Chen, Pengyu

“…Cytokine storm, known as an exaggerated hyperactive immune response characterized by elevated release of cytokines, has been described as a feature associated…”
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A genetic and functional relationship between T cells and cellular proliferation in the adult hippocampus by Huang, Guo-Jen, Smith, Adrian L, Gray, Daniel H D, Cosgrove, Cormac, Singer, Benjamin H, Edwards, Andrew, Sims, Stuart, Sim, Stuart, Parent, Jack M, Johnsen, Alyssa, Mott, Richard, Mathis, Diane, Klenerman, Paul, Benoist, Christophe, Flint, Jonathan

“…Neurogenesis continues through the adult life of mice in the subgranular zone of the dentate gyrus in the hippocampus, but its function remains unclear…”
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Machine learning-based cytokine microarray digital immunoassay analysis by Song, Yujing, Zhao, Jingyang, Cai, Tao, Stephens, Andrew, Su, Shiuan-Haur, Sandford, Erin, Flora, Christopher, Singer, Benjamin H., Ghosh, Monalisa, Choi, Sung Won, Tewari, Muneesh, Kurabayashi, Katsuo

“…Serial measurement of a large panel of protein biomarkers near the bedside could provide a promising pathway to transform the critical care of acutely ill…”
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A tissue chip with integrated digital immunosensors: In situ brain endothelial barrier cytokine secretion monitoring by Su, Shiuan-Haur, Song, Yujing, Stephens, Andrew, Situ, Muyu, McCloskey, Molly C., McGrath, James L., Andjelkovic, Anuska V., Singer, Benjamin H., Kurabayashi, Katsuo

“…Organ-on-a-chip platforms have potential to offer more cost-effective, ethical, and human-resembling models than animal models for disease study and drug…”
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Enrichment of the lung microbiome with gut bacteria in sepsis and the acute respiratory distress syndrome by Dickson, Robert P., Singer, Benjamin H., Newstead, Michael W., Falkowski, Nicole R., Erb-Downward, John R., Standiford, Theodore J., Huffnagle, Gary B.

“…Sepsis and the acute respiratory distress syndrome (ARDS) are major causes of mortality without targeted therapies. Although many experimental and clinical…”
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Miniaturized microarray-format digital ELISA enabled by lithographic protein patterning by Stephens, Andrew D., Song, Yujing, McClellan, Brandon L., Su, Shiuan-Haur, Xu, Sonnet, Chen, Kevin, Castro, Maria G., Singer, Benjamin H., Kurabayashi, Katsuo

“…The search for reliable protein biomarker candidates is critical for early disease detection and treatment. However, current immunoassay technologies are…”
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