Injectable myocardial matrix as a scaffold for myocardial tissue engineering

Injectable myocardial matrix as a scaffold for myocardial tissue engineering

Current injectable materials utilized in myocardial tissue engineering have been borrowed from other tissue engineering applications and have not been specifically designed for the myocardium. We have recently tested the feasibility of using an injectable form of myocardial extracellular matrix that...

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Bibliographic Details
Published in:2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society Vol. 2009; pp. 2406 - 2408
Main Authors: Singelyn, J.M., DeQuach, J.A., Christman, K.L.
Format: Conference Proceeding Journal Article
Language:English
Published: United States IEEE 01-01-2009
Subjects:
Animals
Biological materials
Cardiac tissue
Catheterization
Catheters
Extracellular
Extracellular Matrix - metabolism
Gels
Heart
Heart - physiology
Heart Ventricles - pathology
In vitro
In vivo
Myocardium
Myocardium - pathology
Nanoparticles - chemistry
Nanotechnology - methods
Rats
Swine
Temperature
Testing
Tissue engineering
Tissue Engineering - methods
Tissue Scaffolds
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Description
Summary:Current injectable materials utilized in myocardial tissue engineering have been borrowed from other tissue engineering applications and have not been specifically designed for the myocardium. We have recently tested the feasibility of using an injectable form of myocardial extracellular matrix that would provide cardiac specific matrix cues as well as be amenable to minimally invasive delivery. We have demonstrated that this material self-assembles in vivo to form a nanofibrous scaffold, which supports the infiltration of neovasculature. We have also demonstrated that this material may be delivered minimally invasively through a catheter.
ISSN:1094-687X
1557-170X
1558-4615
DOI:10.1109/IEMBS.2009.5334839