Search Results - "Singeç, I"

Testosterone Metabolism In Rat Brain Is Differentially Enhanced By Phenytoin-Inducible Cytochrome P450 Isoforms by Rosenbrock, H, Hagemeyer, C E, Singeç, I, Knoth, R, Volk, B

“…Many cytochrome P450 (P450) isoforms are selectively inducible by xenobiotics, e.g. pharmaceuticals like the anti‐epileptic drug phenytoin. Some of these P450…”
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Spontaneous reversal of the developmental aging of normal human cells following transcriptional reprogramming by Vaziri, H, Chapman, K B, Guigova, A, Teichroeb, J, Lacher, M D, Sternberg, H, Singec, I, Briggs, L, Wheeler, J, Sampathkumar, J, Gonzalez, R, Larocca, D, Murai, J, Snyder, E, Andrews, W H, Funk, W D, West, M D

“…To determine whether transcriptional reprogramming is capable of reversing the developmental aging of normal human somatic cells to an embryonic state. An…”
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Protein Phosphorylation Signatures Define "Stemness" in Human Pluripotency and Neural Multipotency by Singec, I

“…Understanding defined developmental and cellular states at a systems biology level is one of the great challenges in stem cell biology. Pluripotent stem cells…”
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Direct and Complete Neural Induction of Human ES and iPS Using Small Molecules by Singec, I

“…Pluripotent stem cells can self-renew indefinitely under appropriate cell culture conditions and generate all somatic cell types of the human body. Although…”
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Midkine (MDK): a newly-recognized endogenously-produced cytokine that, through an autocrine mechanism, is pivotal for neural induction by Singec, I, Crain, A M, Tobe, B TD, Hou, J, Talantova, M, Doctor, K S, Choi, J, Huang, X, Gutierrez, G J, Wolf, D A, Lipton, S A, Brill, L M, Snyder, E Y

“…Having devised a novel strategy for deriving pure neuroectoderm from human embryonic stem cells (hESCs), we performed the largest differential…”
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Proof-of-concept: The use of human induced pluripotent stem cells (hiPSCs) to uncover a novel developmentally-based target of therapeutic lithium in bipolar disease (BPD) by Tobe, B TD, Crain, A M, Winquist, A M, Sidor, M, Calabrese, B, Brande, M, Duerr, C, McCarthy, M, McClung, C, Halpain, S, Singec, I, Snyder, E Y

“…Neuropsychiatric disorders are difficult to model not only because their non-specific multigene pattern, but also because of the subjectivity by which they are…”
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Neurogranin expression by cerebellar neurons in rodents and non-human primates by Singec, Ilyas, Knoth, Rolf, Ditter, Margarethe, Frotscher, Michael, Volk, Benedikt

“…Neurogranin (NG) is a brain‐specific protein kinase C substrate involved in the regulation of calcium signaling and neuronal plasticity. A rostrocaudal…”
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Synaptic vesicle protein synaptoporin is differently expressed by subpopulations of mouse hippocampal neurons by Singec, Ilyas, Knoth, Rolf, Ditter, Margarethe, Hagemeyer, Christoph E., Rosenbrock, Holger, Frotscher, Michael, Volk, Benedikt

“…In the hippocampus, the synaptic vesicle protein synaptoporin (SPO) has been reported to be exclusively enriched in the granule cell axons, the mossy fibers…”
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Different testosterone metabolism by immortalized embryonic and postnatal hippocampal neurons from C57BL/6 mice: A crucial role for androstenedione by Hagemeyer, Christoph E., Rosenbrock, Holger, Singec, Ilyas, Knoth, Rolf, Volk, Benedikt

“…Steroid hormones influence the development of undifferentiated brain during ontogenesis. In the present study we investigated the metabolic pathway of…”
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