Search Results - "Singaraja, Roshni"

Bile Acids: A Communication Channel in the Gut-Brain Axis by Monteiro-Cardoso, Vera F., Corlianò, Maria, Singaraja, Roshni R.

“…Bile acids are signalling hormones involved in the regulation of several metabolic pathways. The ability of bile acids to bind and signal through their…”
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1714-P: Absence of CYP8B1 Increases Insulin Sensitivity in Part via Modulation of the Gut Microbiome by CORLIANÒ, MARIA, ZHONG, SHIQI, SINGARAJA, ROSHNI R.

“…Disruption of a key bile acid synthesis enzyme, CYP8B1, results in the absence of cholic acid (CA), increased levels of chenodeoxycholic acid (CDCA) and…”
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Stem cell-derived polarized hepatocytes by Dao Thi, Viet Loan, Wu, Xianfang, Belote, Rachel L., Andreo, Ursula, Takacs, Constantin N., Fernandez, Joseph P., Vale-Silva, Luis Andre, Prallet, Sarah, Decker, Charlotte C., Fu, Rebecca M., Qu, Bingqian, Uryu, Kunihiro, Molina, Henrik, Saeed, Mohsan, Steinmann, Eike, Urban, Stephan, Singaraja, Roshni R., Schneider, William M., Simon, Sanford M., Rice, Charles M.

“…Human stem cell-derived hepatocyte-like cells (HLCs) offer an attractive platform to study liver biology. Despite their numerous advantages, HLCs lack critical…”
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Loss of Cyp8b1 improves glucose homeostasis by increasing GLP-1 by Kaur, Achint, Patankar, Jay V, de Haan, Willeke, Ruddle, Piers, Wijesekara, Nadeeja, Groen, Albert K, Verchere, C Bruce, Singaraja, Roshni R, Hayden, Michael R

“…Besides their role in facilitating lipid absorption, bile acids are increasingly being recognized as signaling molecules that activate cell-signaling…”
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FURIN Inhibition Reduces Vascular Remodeling and Atherosclerotic Lesion Progression in Mice by Yakala, Gopala K, Cabrera-Fuentes, Hector A, Crespo-Avilan, Gustavo E, Rattanasopa, Chutima, Burlacu, Alexandrina, George, Benjamin L, Anand, Kaviya, Mayan, David Castaño, Corlianò, Maria, Hernández-Reséndiz, Sauri, Wu, Zihao, Schwerk, Anne M.K, Tan, Amberlyn L.J, Trigueros-Motos, Laia, Chèvre, Raphael, Chua, Tricia, Kleemann, Robert, Liehn, Elisa A, Hausenloy, Derek J, Ghosh, Sujoy, Singaraja, Roshni R

“…OBJECTIVE—Atherosclerotic coronary artery disease is the leading cause of death worldwide, and current treatment options are insufficient. Using systems-level…”
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Lipid efflux mechanisms, relation to disease and potential therapeutic aspects by Castaño, David, Rattanasopa, Chutima, Monteiro-Cardoso, Vera F., Corlianò, Maria, Liu, Yiran, Zhong, Shiqi, Rusu, Mihaela, Liehn, Elisa A., Singaraja, Roshni R.

“…Lipids are hydrophobic and amphiphilic molecules involved in diverse functions such as membrane structure, energy metabolism, immunity, and signaling. However,…”
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Loss of ABCA8B decreases myelination by reducing oligodendrocyte precursor cells in mice by Liu, Yiran, Castano, David, Girolamo, Francesco, Trigueros-Motos, Laia, Bae, Han-Gyu, Neo, Suat Peng, Oh, Jeongah, Narayanaswamy, Pradeep, Torta, Federico, Rye, Kerry Anne, Jo, Dong-Gyu, Gunaratne, Jayantha, Jung, Sangyong, Virgintino, Daniela, Singaraja, Roshni R.

“…The myelin sheath, which is wrapped around axons, is a lipid-enriched structure produced by mature oligodendrocytes. Disruption of the myelin sheath is…”
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Functional and Multi-Omics Effects of an Optimized CRISPR-Mediated FURIN Depletion in U937 Monocytes by Chua, Ruiming, Wang, Lijin, Singaraja, Roshni, Ghosh, Sujoy

“…The pro-protein convertase FURIN (PCSK3) is implicated in a wide range of normal and pathological biological processes such as infectious diseases, cancer and…”
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Haploinsufficiency of CYP8B1 associates with increased insulin sensitivity in humans by Zhong, Shiqi, Chèvre, Raphael, Castaño Mayan, David, Corlianò, Maria, Cochran, Blake J, Sem, Kai Ping, van Dijk, Theo H, Peng, Jianhe, Tan, Liang Juin, Hartimath, Siddesh V, Ramasamy, Boominathan, Cheng, Peter, Groen, Albert K, Kuipers, Folkert, Goggi, Julian L, Drum, Chester, van Dam, Rob M, Tan, Ru San, Rye, Kerry-Anne, Hayden, Michael R, Cheng, Ching-Yu, Chacko, Shaji, Flannick, Jason, Sim, Xueling, Tan, Hong Chang, Singaraja, Roshni R

“…BACKGROUNDCytochrome P450 family 8 subfamily B member 1 (CYP8B1) generates 12α-hydroxylated bile acids (BAs) that are associated with insulin resistance in…”
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A neutralizing IL-11 antibody reduces vessel hyperplasia in a mouse carotid artery wire injury model by Schumacher, David, Liehn, Elisa A., Nilcham, Pakhwan, Mayan, David Castaño, Rattanasopa, Chutima, Anand, Kaviya, Crespo-Avilan, Gustavo E., Hernandez-Resendiz, Sauri, Singaraja, Roshni R., Cook, Stuart A., Hausenloy, Derek J.

“…Vascular restenosis remains a major problem in patients with coronary artery disease (CAD) and peripheral artery disease (PAD). Neointimal hyperplasia, defined…”
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Palmitoylation of caspase-6 by HIP14 regulates its activation by Skotte, Niels H, Sanders, Shaun S, Singaraja, Roshni R, Ehrnhoefer, Dagmar E, Vaid, Kuljeet, Qiu, Xiaofan, Kannan, Srinivasaragavan, Verma, Chandra, Hayden, Michael R

“…Caspase-6 (CASP6) has an important role in axonal degeneration during neuronal apoptosis and in the neurodegenerative diseases Alzheimer and Huntington…”
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Therapeutic modulation of the bile acid pool by Cyp8b1 knockdown protects against nonalcoholic fatty liver disease in mice by Chevre, Raphael, Trigueros‐Motos, Laia, Castaño, David, Chua, Tricia, Corlianò, Maria, Patankar, Jay V., Sng, Lareina, Sim, Lauren, Juin, Tan Liang, Carissimo, Guillaume, Ng, Lisa F. P., Yi, Cheryl Neo Jia, Eliathamby, Chelsea Chandani, Groen, Albert K., Hayden, Michael R., Singaraja, Roshni R.

“…Bile acids (BAs) are surfactant molecules that regulate the intestinal absorption of lipids. Thus, the modulation of BAs represents a potential therapy for…”
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Memory and synaptic deficits in Hip14/DHHC17 Knockout mice by Milnerwood, Austen J., Parsons, Matthew P., Young, Fiona B., Singaraja, Roshni R., Franciosi, Sonia, Volta, Mattia, Bergeron, Sabrina, Hayden, Michael R., Raymond, Lynn A.

“…Palmitoylation of neurotransmitter receptors and associated scaffold proteins regulates their membrane association in a rapid, reversible, and…”
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Caffeine prevents restenosis and inhibits vascular smooth muscle cell proliferation through the induction of autophagy by Tripathi, Madhulika, Singh, Brijesh Kumar, Liehn, Elisa A., Lim, Sheau Yng, Tikno, Keziah, Castano-Mayan, David, Rattanasopa, Chutima, Nilcham, Pakhwan, Abdul Ghani, Siti Aishah Binte, Wu, Zihao, Azhar, Syaza Hazwany, Zhou, Jin, Hernández-Resèndiz, Sauri, Crespo-Avilan, Gustavo E., Sinha, Rohit Anthony, Farah, Benjamin Livingston, Moe, Kyaw Thu, De Silva, Deidre Anne, Angeli, Veronique, Singh, Manvendra K., Singaraja, Roshni R., Hausenloy, Derek J., Yen, Paul Michael

“…Caffeine is among the most highly consumed substances worldwide, and it has been associated with decreased cardiovascular risk. Although caffeine has been…”
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Palmitoylation of huntingtin by HIP14is essential for its trafficking and function by Yanai, Anat, Huang, Kun, Kang, Rujun, Singaraja, Roshni R, Arstikaitis, Pamela, Gan, Lu, Orban, Paul C, Mullard, Asher, Cowan, Catherine M, Raymond, Lynn A, Drisdel, Renaldo C, Green, William N, Ravikumar, Brinda, Rubinsztein, David C, El-Husseini, Alaa, Hayden, Michael R

“…Post-translational modification by the lipid palmitate is crucial for the correct targeting and function of many proteins. Here we show that huntingtin (htt)…”
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Specific Loss of Brain ABCA1 Increases Brain Cholesterol Uptake and Influences Neuronal Structure and Function by Karasinska, Joanna M, Rinninger, Franz, Lutjohann, Dieter, Ruddle, Piers, Franciosi, Sonia, Kruit, Janine K, Singaraja, Roshni R, Hirsch-Reinshagen, Veronica, Fan, Jianjia, Brunham, Liam R, Bissada, Nagat, Ramakrishnan, Rajasekhar, Wellington, Cheryl L, Parks, John S, Hayden, Michael R

“…The expression of the cholesterol transporter ATP-binding cassette transporter A1 (ABCA1) in the brain and its role in the lipidation of apolipoproteins…”
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Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function by El-Husseini, Alaa, Hayden, Michael R, Yanai, Anat, Huang, Kun, Kang, Rujun, Singaraja, Roshni R, Arstikaitis, Pamela, Gan, Lu, Orban, Paul C, Mullard, Asher, Cowan, Catherine M, Raymond, Lynn A, Drisdel, Renaldo C, Green, William N, Ravikumar, Brinda, Rubinsztein, David C

“…Post-translational modification by the lipid palmitate is crucial for the correct targeting and function of many proteins. Here we show that huntingtin (htt)…”
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The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease by Butland, Stefanie L, Sanders, Shaun S, Schmidt, Mandi E, Riechers, Sean-Patrick, Lin, David T S, Martin, Dale D O, Vaid, Kuljeet, Graham, Rona K, Singaraja, Roshni R, Wanker, Erich E, Conibear, Elizabeth, Hayden, Michael R

“…HIP14 is the most highly conserved of 23 human palmitoyl acyltransferases (PATs) that catalyze the post-translational addition of palmitate to proteins,…”
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Targeted next-generation sequencing to diagnose disorders of HDL cholesterol by Sadananda, Singh N., Foo, Jia Nee, Toh, Meng Tiak, Cermakova, Lubomira, Trigueros-Motos, Laia, Chan, Teddy, Liany, Herty, Collins, Jennifer A., Gerami, Sima, Singaraja, Roshni R., Hayden, Michael R., Francis, Gordon A., Frohlich, Jiri, Khor, Chiea Chuen, Brunham, Liam R.

“…A low level of HDL cholesterol (HDL-C) is a common clinical scenario and an important marker for increased cardiovascular risk. Many patients with very low or…”
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Huntingtin-Interacting Protein HIP14 Is a Palmitoyl Transferase Involved in Palmitoylation and Trafficking of Multiple Neuronal Proteins by Huang, Kun, Yanai, Anat, Kang, Rujun, Arstikaitis, Pamela, Singaraja, Roshni R., Metzler, Martina, Mullard, Asher, Haigh, Brendan, Gauthier-Campbell, Catherine, Gutekunst, Claire-Anne, Hayden, Michael R., El-Husseini, Alaa

“…In neurons, posttranslational modification by palmitate regulates the trafficking and function of signaling molecules, neurotransmitter receptors, and…”
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