Structural and Functional Analysis of the Spermatogenic Epithelium in Rats Exposed to Titanium Dioxide Nanoparticles

We studied immunohistochemical and morphometric characteristics of the spermatogenic epithelium in rats against the background of peroral administration of nanoparticles containing titanium dioxide. Substantial degenerative changes in the spermatogenic epithelium were revealed: thinning, disorganiza...

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Bibliographic Details
Published in:	Bulletin of experimental biology and medicine Vol. 166; no. 2; pp. 279 - 282
Main Authors:	Sharafutdinova, L. A., Fedorova, A. M., Bashkatov, S. A., Sinel’nikov, K. N., Valiullin, V. V.
Format:	Journal Article
Language:	English
Published:	New York Springer US 01-12-2018 Springer Nature B.V
Subjects:	60 APPLIED LIFE SCIENCES Administration, Oral Animals Biomarkers - metabolism Biomedical and Life Sciences Biomedicine c-Kit protein Cell Biology Cell Differentiation - drug effects Cell Proliferation - drug effects Epithelial cells EPITHELIUM FUNCTIONAL ANALYSIS Internal Medicine Ki-67 Antigen - metabolism Laboratory Medicine Leydig Cells - drug effects Leydig Cells - metabolism Leydig Cells - ultrastructure Male MEMBRANES NANOPARTICLES Nanoparticles - administration & dosage Nanoparticles - chemistry Pathology RATS Rats, Wistar Reproductive system Rodents Seminiferous Tubules - drug effects Seminiferous Tubules - metabolism Seminiferous Tubules - ultrastructure Sertoli Cells - drug effects Sertoli Cells - metabolism Sertoli Cells - ultrastructure Sperm Count SPERMATOGENESIS Spermatogenesis - drug effects SPERMATOZOA Spermatozoa - cytology Spermatozoa - drug effects Structure-function relationships Titanium Titanium - administration & dosage Titanium dioxide TITANIUM OXIDES TOXICITY toxicity spermatogenesis titanium dioxide nanoparticles
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Summary:	We studied immunohistochemical and morphometric characteristics of the spermatogenic epithelium in rats against the background of peroral administration of nanoparticles containing titanium dioxide. Substantial degenerative changes in the spermatogenic epithelium were revealed: thinning, disorganization of layers, and detachment of sperm cells from the basement membrane. Immunohistochemical analysis revealed reduced proliferative activity and differentiation potential of epithelial cells, which was confirmed by changes in the expression of Ki-67 and c-kit markers. Our data attest to unfavorable effects of titanium dioxide nanoparticles on the structural and functional characteristics of the reproductive system in male rats leading to spermatogenesis disturbances.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-018-4332-2