Search Results - "Sindhu, Kizhakke M."

Acute intranigral infusion of rotenone in rats causes progressive biochemical lesions in the striatum similar to Parkinson's disease by Saravanan, Karuppagounder S., Sindhu, Kizhakke M., Mohanakumar, Kochupurackal P.

“…We examined in Sprague–Dawley rats whether intranigral administration of complex-I inhibitor, rotenone, produces biochemical lesions in the striatum similar to…”
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Swim-test as a function of motor impairment in MPTP model of Parkinson's disease: A comparative study in two mouse strains by Haobam, Reena, Sindhu, Kizhakke M., Chandra, Goutam, Mohanakumar, Kochupurackal P.

“…Parkinson's disease (PD) is a common neurodegenerative disease that exhibits motor dysfunctions, such as tremor, akinesia and rigidity. In the present study,…”
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Melatonin protects against rotenone-induced oxidative stress in a hemiparkinsonian rat model by Saravanan, Karuppagounder S., Sindhu, Kizhakke M., Mohanakumar, Kochupurackal P.

“…:  In the present study, we evaluated the effect of melatonin, a well‐known free radical scavenger and neuroprotector, against rotenone‐induced oxidative…”
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Mitochondrial NAD⁺-linked State 3 respiration and complex-I activity are compromised in the cerebral cortex of 3-nitropropionic acid-induced rat model of Huntington's disease by Pandey, Mritunjay, Varghese, Merina, Sindhu, Kizhakke M, Sreetama, Sen, Navneet, A.K, Mohanakumar, Kochupurackal P, Usha, Rajamma

“…Mitochondrial complex-I dysfunction has been observed in patients of Huntington's disease (HD). We assessed whether such a defect is present in the…”
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l-deprenyl protects against rotenone-induced, oxidative stress-mediated dopaminergic neurodegeneration in rats by Saravanan, Karuppagounder S., Sindhu, Kizhakke M., Senthilkumar, Karuppagounder S., Mohanakumar, Kochupurackal P.

“…The present study investigated oxidative damage and neuroprotective effect of the antiparkinsonian drug, l-deprenyl in neuronal death produced by intranigral…”
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Behavioral differences in a rotenone-induced hemiparkinsonian rat model developed following intranigral or median forebrain bundle infusion by Sindhu, Kizhakke M., Saravanan, Karuppagounder S., Mohanakumar, Kochupurackal P.

“…A mitochondrial complex-I inhibitor, rotenone was unilaterally infused into the substantia nigra pars compacta (SNpc) or median forebrain bundle (MFB) to…”
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Unilateral implantation of dopamine-loaded biodegradable hydrogel in the striatum attenuates motor abnormalities in the 6-hydroxydopamine model of hemi-parkinsonism by Senthilkumar, Karuppagounder S., Saravanan, Karuppagounder S., Chandra, Goutam, Sindhu, Kizhakke M., Jayakrishnan, A., Mohanakumar, Kochupurackal P.

“…Dopaminergic functional recovery following controlled release of dopamine from biodegradable polymer matrices implanted in the lesioned striatum was…”
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Rats with unilateral median forebrain bundle, but not striatal or nigral, lesions by the neurotoxins MPP + or rotenone display differential sensitivity to amphetamine and apomorphine by Sindhu, Kizhakke M., Banerjee, Rebecca, Senthilkumar, Karuppagounder S., Saravanan, Karuppagounder S., Raju, B. China, Rao, J. Madhusudan, Mohanakumar, Kochupurackal P.

“…Rotenone and 1-methyl-4-phenyl pyridinium (MPP +) are two mitochondrial neurotoxins known to produce Parkinson's disease (PD) in experimental animals. In the…”
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Mitochondrial NAD+-linked State 3 respiration and complex-1 activity are compromised in the cerebral cortex of 3-nitropropionic acid-induced rat model of Huntington's disease by PANDEY, Mritunjay, VARGHESE, Merina, SINDHU, Kizhakke M, SREETAMA, Sen, NAVNEET, A. K, MOHANAKUMAR, Kochupurackal P, USHA, Rajamma

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Rats with unilateral median forebrain bundle, but not striatal or nigral, lesions by the neurotoxins MPP super(+) or rotenone display differential sensitivity to amphetamine and apomorphine by Sindhu, Kizhakke M, Banerjee, Rebecca, Senthilkumar, Karuppagounder S, Saravanan, Karuppagounder S, Raju, BChina, Rao, JMadhusudan, Mohanakumar, Kochupurackal P

“…Rotenone and 1-methyl-4-phenyl pyridinium (MPP super(+)) are two mitochondrial neurotoxins known to produce Parkinson's disease (PD) in experimental animals…”
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