Search Results - "Sinclair, P R"

Hormonal palliation of chemoresistant ovarian cancer: three consecutive phase II trials of the Mid-Atlantic Oncology Program by Ahlgren, J D, Ellison, N M, Gottlieb, R J, Laluna, F, Lokich, J J, Sinclair, P R, Ueno, W, Wampler, G L, Yeung, K Y, Alt, D

“…To evaluate the efficacy of three hormonal manipulations in the palliation of chemoresistant ovarian cancer, and to analyze the results in the light of other…”
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CYP1A2 Is Essential in Murine Uroporphyria Caused by Hexachlorobenzene and Iron by Sinclair, Peter R., Gorman, Nadia, Walton, Heidi S., Bement, William J., Dalton, Timothy P., Sinclair, Jacqueline F., Smith, Andrew G., Nebert, Daniel W.

“…Using Cyp1a2(−/−) mice we previously showed that CYP1A2 is absolutely required for hepatic uroporphyrin accumulation caused by iron and 5-aminolevulinate (ALA)…”
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Synergistic increases in rat hepatic cytochrome P450s by ethanol and isopentanol by Louis, C A, Wood, S G, Kostrubsky, V, Sinclair, P R, Sinclair, J F

“…The purpose of this study was to determine if isopentanol alone or in combination with ethanol increased CYP2B1/2, CYP2E or CYP3A in the livers of rats…”
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Effect of Arsenite on Induction of CYP1A, CYP2B, and CYP3A in Primary Cultures of Rat Hepatocytes by Jacobs, Judith M., Nichols, Calen E., Andrew, Angeline S., Marek, Doreen E., Wood, Sheryl G., Sinclair, Peter R., Wrighton, Steven A., Kostrubsky, Vsevolod E., Sinclair, Jacqueline F.

“…In earlier studies, sodium arsenite treatment was shown to decrease induction of enzymatic activities associated with hepatic CYPs in rats. Here we…”
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Ascorbic acid inhibits chemically induced uroporphyria in ascorbate-requiring rats by Sinclair, P R, Gorman, N, Sinclair, J F, Walton, H S, Bement, W J, Lambrecht, R W

“…Ascorbate was previously shown to suppress accumulation of uroporphyrin (URO) in cultured chick embryo hepatocytes and to competitively inhibit microsomal…”
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Acetaminophen hepatotoxicity precipitated by short-term treatment of rats with ethanol and isopentanol: Protection by triacetyloleandomycin by Sinclair, Jacqueline F, Szakacs, Juliana G, Wood, Sheryl G, Kostrubsky, Vsevolod E, Jeffery, Elizabeth H, Wrighton, Steven A, Bement, William J, Wright, Dane, Sinclair, Peter R

“…Ethanol and isopentanol are the predominant alcohols in alcoholic beverages. We have reported previously that pretreatment of rats with a liquid diet…”
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Uroporphyrinogen Oxidation Catalyzed by Human Cytochromes P450 by SINCLAIR, P. R, GORMAN, N, TSYRLOV, I. B, FUHR, U, WALTON, H. S, SINCLAIR, J. F

“…Porphyria cutanea tarda is associated with excess hepatic production of uroporphyrin. Oxidation of uroporphyrinogen to uroporphyrin was previously demonstrated…”
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Identification of CYP1A5 as the CYP1A Enzyme Mainly Responsible for Uroporphyrinogen Oxidation Induced by Ah Receptor Ligands in Chicken Liver and Kidney by SINCLAIR, P. R, GORMAN, N, WALTON, H. S, SINCLAIR, J. F, LEE, C. A, RIFKIND, A. B

“…Uroporphyrinogen is an intermediate of the heme biosynthetic pathway. The oxidation of uroporphyrinogen to uroporphyrin (UROX) has been demonstrated to be…”
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Hemopexin from four species inhibits the association of heme with cultured hepatoma cells or primary rat hepatocytes exhibiting a small number of species specific hemopexin receptors by Taketani, Shigeru, Immenschuh, Stephan, Go, Sien, Sinclair, Peter R., Stockert, Richard J., Liem, H. Heng, Eberhard, Ursula Muller

“…Hemopexin (Hx) binds heme with a very high affinity (Kd<0.1 pmol/L). It has been implicated as a major vehicle for the transport of heme into liver cells,…”
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Role of CYP3A in Ethanol-Mediated Increases in Acetaminophen Hepatotoxicity by Kostrubsky, Vsevolod E., Szakacs, Juliana G., Jeffery, Elizabeth H., Wood, Sheryl G., Bement, William J., Wrighton, Steven A., Sinclair, Peter R., Sinclair, Jacqueline F.

“…CYP2E is considered the only form of cytochrome P450 responsible for ethanol-mediated increases in acetaminophen hepatotoxicity. However, in experimental…”
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Role of small differences in CYP1A2 in the development of uroporphyria produced by iron and 5-aminolevulinate in C57BL/6 and SWR strains of mice by Gorman, Nadia, Walton, Heidi S, Bement, William J, Honsinger, Charles P, Szakacs, Juliana G, Sinclair, Jacqueline F, Sinclair, Peter R

“…Previous work has implicated CYP1A2 in experimental uroporphyria caused by polyhalogenated aromatic compounds, and in uroporphyria caused by iron and…”
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Heme regulates hepatic 5-aminolevulinate synthase mRNA expression by decreasing mRNA half-life and not by altering its rate of transcription by Hamilton, J W, Bement, W J, Sinclair, P R, Sinclair, J F, Alcedo, J A, Wetterhahn, K E

“…Hepatic 5-aminolevulinate (ALA) synthase, the first and rate-limiting enzyme in the heme biosynthetic pathway, is known to be feedback repressed by the end…”
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Effect of Taxol on Cytochrome P450 3A and Acetaminophen Toxicity in Cultured Rat Hepatocytes: Comparison to Dexamethasone by Kostrubsky, Vsevolod E., Lewis, Lionel D., Wood, Sheryl G., Sinclair, Peter R., Wrighton, Steven A., Sinclair, Jacqueline F.

“…The purpose of this study was to determine if Taxol induced CYP3A in primary cultures of rat hepatocytes and, if so, whether induction of CYP3A would increase…”
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Uroporphyrinogen oxidation catalyzed by reconstituted cytochrome P450IA2 by Lambrecht, R W, Sinclair, P R, Gorman, N, Sinclair, J F

“…Previous work suggested that the oxidation of uroporphyrinogen to uroporphyrin is catalyzed by cytochrome P450IA2. Here we determined whether purified…”
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Multiple Roles of Polyhalogenated Biphenyls in Causing Increases in Cytochrome P450 and Uroporphyrin Accumulation in Cultured Hepatocytes by Sinclair, Peter R., Walton, Heidi S., Gorman, Nadia, Jacobs, Judith M., Sinclair, Jacqueline F.

“…Uroporphyrin (URO) accumulation occurs in chick embryo hepatocytes treated with a number of polyhalogenated aromatic hydrocarbons (PHAHs) that are known…”
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Formation of zinc protoporphyrin in cultured hepatocytes: effects of ferrochelatase inhibition, iron chelation or lead by Jacobs, Judith M, Sinclair, Peter R, Sinclair, Jacqueline F, Gorman, Nadia, Walton, Heidi S, Wood, Sheryl G, Nichols, Calen

“…The formation of zinc protoporphyrin in response to lead or iron depletion has previously been investigated in erythroid systems. Because of its possible…”
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Expression of 5-aminolaevulinate synthase and cytochrome P-450 mRNAs in chicken embryo hepatocytes in vivo and in culture. Effect of porphyrinogenic drugs and haem by Hamilton, J W, Bement, W J, Sinclair, P R, Sinclair, J F, Wetterhahn, K E

“…To examine current models for the co-ordinate regulation of 5-aminolaevulinate (ALA) synthase and cytochrome P-450 we have determined the effect of drugs,…”
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Acute hepatotoxicity of acetaminophen in rats treated with ethanol plus isopentanol by Kostrubsky, Vsevolod E., Wood, Sheryl G., Bush, Matthew D., Szakacs, Juliana, Bement, William J., Sinclair, Peter R., Jeffery, Elizabeth H., Sinclair, Jacqueline F.

“…Acetaminophen (APAP) hepatotoxicity was investigated in rats fed ethanol and isopentanol alone or in combination in a liquid diet for 7 days. Serum levels of…”
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Effect of interleukin 6 on phenobarbital induction of cytochrome P-450IIB in cultured rat hepatocytes by Williams, J F, Bement, W J, Sinclair, J F, Sinclair, P R

“…Human recombinant interleukin 6 (rhIL-6) caused a dose dependent decrease in the phenobarbital induction of benzyloxyresorufin O-deethylase activity in…”
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Oxidation of uroporphyrinogen by methylcholanthrene-induced cytochrome P-450. Essential role of cytochrome P-450d by Jacobs, J M, Sinclair, P R, Bement, W J, Lambrecht, R W, Sinclair, J F, Goldstein, J A

“…We have previously shown that uroporphyrinogen is oxidized to uroporphyrin by microsomes (microsomal fractions) from 3-methylcholanthrene-pretreated chick…”
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