Search Results - "Sinclair, J. H."

Targeting the latent cytomegalovirus reservoir with an antiviral fusion toxin protein by Krishna, B. A., Spiess, K., Poole, E. L., Lau, B., Voigt, S., Kledal, T. N., Rosenkilde, M. M., Sinclair, J. H.

“…Reactivation of human cytomegalovirus (HCMV) in transplant recipients can cause life-threatening disease. Consequently, for transplant recipients, killing…”
Get full text

Latency, Chromatin Remodeling, and Reactivation of Human Cytomegalovirus in the Dendritic Cells of Healthy Carriers by Reeves, M. B., MacAry, P. A., Lehner, P. J., Sissons, J. G. P., Sinclair, J. H., Kieff, Elliott D.

“…Human cytomegalovirus (HCMV) persists as a subclinical, lifelong infection in the normal human host, but reactivation from latency in immunocompromised…”
Get full text

An in vitro model for the regulation of human cytomegalovirus latency and reactivation in dendritic cells by chromatin remodelling by Reeves, M. B, Lehner, P. J, Sissons, J. G. P, Sinclair, J. H

“…1 Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Level 5 Box 157, Hills Road, Cambridge CB2 2QQ, UK 2 Cambridge Institute for Medical…”
Get full text

Human Cytomegalovirus Infection Upregulates the Mitochondrial Transcription and Translation Machineries by Karniely, S, Weekes, M P, Antrobus, R, Rorbach, J, van Haute, L, Umrania, Y, Smith, D L, Stanton, R J, Minczuk, M, Lehner, P J, Sinclair, J H

“…Infection with human cytomegalovirus (HCMV) profoundly affects cellular metabolism. Like in tumor cells, HCMV infection increases glycolysis, and glucose…”
Get full text

Advances in the treatment of cytomegalovirus by Krishna, B A, Wills, M R, Sinclair, J H

“…Human cytomegalovirus (HCMV) is a threat to immunologically weak patients. HCMV cannot yet be eliminated with a vaccine, despite recent advances. Sources of…”
Get full text

Human Cytomegalovirus Infection Inhibits Tumor Necrosis Factor Alpha (TNF-α) Signaling by Targeting the 55-Kilodalton TNF-α Receptor by Baillie, J, Sahlender, D A, Sinclair, J H

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Monocytes are a major site of persistence of human cytomegalovirus in peripheral blood mononuclear cells by Taylor-Wiedeman, Jean, Sissons, J. G. P, Borysiewicz, L. K, Sinclair, J. H

“…Department of Medicine, University of Cambridge Clinical School, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, U.K. We have used the nested polymerase…”
Get full text

Human cytomegalovirus infection of the monocyte/macrophage lineage in bone marrow by MINTON, E. J, TYSOE, C, SINCLAIR, J. H, SISSONS, J. G. P

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Transient activation of human cytomegalovirus lytic gene expression during latency allows cytotoxic T cell killing of latently infected cells by Krishna, B. A., Lau, B., Jackson, S. E., Wills, M. R., Sinclair, J. H., Poole, E.

“…Human cytomegalovirus (HCMV) latency in the myeloid lineage is maintained by repressive histone modifications around the major immediate early promoter (MIEP),…”
Get full text

Human cytomegalovirus infection inhibits epidermal growth factor (EGF) signalling by targeting EGF receptors by Fairley, J. A, Baillie, J, Bain, M, Sinclair, J. H

“…Department of Medicine, University of Cambridge, Level 5, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QQ, UK 1 Division of Biochemistry and Molecular…”
Get full text

The Human Cytomegalovirus 86-Kilodalton Major Immediate-Early Protein Interacts Physically and Functionally with Histone Acetyltransferase P/CAF by Bryant, L A, Mixon, P, Davidson, M, Bannister, A J, Kouzarides, T, Sinclair, J H

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

The human cytomegalovirus IE1-72 protein interacts with the cellular p107 protein and relieves p107-mediated transcriptional repression of an E2F-responsive promoter by Poma, E E, Kowalik, T F, Zhu, L, Sinclair, J H, Huang, E S

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

CCAAT box-dependent activation of the TATA-less human DNA polymerase alpha promoter by the human cytomegalovirus 72-kilodalton major immediate-early protein by Hayhurst, G P, Bryant, L A, Caswell, R C, Walker, S M, Sinclair, J H

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Human cytomegalovirus and immunopathology by Sissons, J G P, Carmichael, A J, McKinney, N, Sinclair, J H, Wills, M R

Get full text

Repression of human cytomegalovirus major immediate early gene expression in a monocytic cell line by Sinclair, J. H, Baillie, J, Bryant, L. A, Taylor-Wiedeman, J. A, Sissons, J. G. P

“…Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, U.K. We have previously shown that a major site of…”
Get full text

Polymorphonuclear cells are not sites of persistence of human cytomegalovirus in healthy individuals by Taylor-Wiedeman, Jean, Hayhurst, G. P, Sissons, J. G. P, Sinclair, J. H

“…University of Cambridge Clinical School, Department of Medicine, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, U.K. Polymorphonuclear leukocytes…”
Get full text

Control of cytomegalovirus lytic gene expression by histone acetylation by Murphy, Jane C., Fischle, Wolfgang, Verdin, Eric, Sinclair, John H.

“…Permissiveness for human cytomegalovirus (HCMV) infection is dependent on the state of cellular differentiation and has been linked to repression of the viral…”
Get full text

A 10-base-pair element of the human immunodeficiency virus type 1 long terminal repeat (LTR) is an absolute requirement for transactivation by the human cytomegalovirus 72-kilodalton IE1 protein but can be compensated for by other LTR regions in transactivation by the 80-kilodalton IE2 protein by WALKER, S, HAGEMIER, C, PATRICK SISSONS, J. G, SINCLAIR, J. H

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Inhibition of human cytomegalovirus major immediate early gene expression by antisense RNA expression vectors by Bryant, Linda A, Sinclair, John H

“…Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, U.K. We have used antisense oligonucleotides and…”
Get full text

In vitro expression of calcitonin gene-related peptide in human endothelial cells transfected with plasmid and retroviral vectors by Sun, B, Plumpton, C, Sinclair, J H, Brown, M J

“…Introduction of cDNA encoding human alpha-calcitonin gene-related peptide (CGRP), a potent vasodilator, into cultured human umbilical vein endothelial cells…”
Get more information