Search Results - "Sinclair, Donald A R"

Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc) by Sinclair, Donald A.R, Syrzycka, Monika, Macauley, Matthew S, Rastgardani, Tara, Komljenovic, Ivana, Vocadlo, David J, Brock, Hugh W, Honda, Barry M

“…O-linked N-acetylglucosamine transferase (OGT) reversibly modifies serine and threonine residues of many intracellular proteins with a single β-O-linked…”
Get full text

Homeodomain-interacting protein kinase (Hipk) plays roles in nervous system and muscle structure and function by Wang, Simon J H, Sinclair, Donald A R, Kim, Hae-Yoon, Kinsey, Stephen D, Yoo, Byoungjoo, Shih, Claire R Y, Wong, Kenneth K L, Krieger, Charles, Harden, Nicholas, Verheyen, Esther M

“…Homeodomain-interacting protein kinases (Hipks) have been previously associated with cell proliferation and cancer, however, their effects in the nervous…”
Get full text

Drosophila cohesin subunit Rad21 is a trithorax group (trxG) protein by Hallson, Graham, Syrzycka, Monika, Beck, Samantha A, Kennison, James A, Dorsett, Dale, Page, Scott L, Hunter, Sally M, Keall, Rebecca, Warren, William D, Brock, Hugh W, Sinclair, Donald A.R, Honda, Barry M

“…The cohesin complex is a key player in regulating cell division. Cohesin proteins SMC1, SMC3, Rad21, and stromalin (SA), along with associated proteins…”
Get full text

A Genetic and Molecular Characterization of Two Proximal Heterochromatic Genes on Chromosome 3 of Drosophila melanogaster by Schulze, Sandra R, Sinclair, Donald A. R, Fitzpatrick, Kathleen A, Honda, Barry M

“…Heterochromatin comprises a transcriptionally repressive chromosome compartment in the eukaryotic nucleus; this is exemplified by the silencing effect it has…”
Get full text

Heterochromatic Genes in Drosophila: A Comparative Analysis of Two Genes by Schulze, Sandra R, McAllister, Bryant F, Sinclair, Donald A. R, Fitzpatrick, Kathleen A, Marchetti, Marcella, Pimpinelli, Sergio, Honda, Barry M

“…Centromeric heterochromatin comprises approximately 30% of the Drosophila melanogaster genome, forming a transcriptionally repressive environment that silences…”
Get full text

The nutrient sensor OGT regulates Hipk stability and tumorigenic-like activities in Drosophila by Wong, Kenneth Kin Lam, Liu, Ta-Wei, Parker, Jessica M., Sinclair, Donald A. R., Chen, Yi-Yun, Khoo, Kay-Hooi, Vocadlo, David J., Verheyen, Esther M.

“…Environmental cues such as nutrients alter cellular behaviors by acting on a wide array of molecular sensors inside cells. Of emerging interest is the link…”
Get full text

dSet1 is the main H3K4 di- and tri-methyltransferase throughout Drosophila development by Hallson, Graham, Hollebakken, Robert E, Li, Taosui, Syrzycka, Monika, Kim, Inho, Cotsworth, Shawn, Fitzpatrick, Kathleen A, Sinclair, Donald A R, Honda, Barry M

“…In eukaryotes, the post-translational addition of methyl groups to histone H3 lysine 4 (H3K4) plays key roles in maintenance and establishment of appropriate…”
Get full text

The pink gene encodes the Drosophila orthologue of the human Hermansky-Pudlak syndrome 5 (HPS5) gene by Syrzycka, Monika, McEachern, Lori A, Kinneard, Jennifer, Prabhu, Kristel, Fitzpatrick, Kathleen, Schulze, Sandra, Rawls, John M, Lloyd, Vett K, Sinclair, Donald A R, Honda, Barry M

“…Hermansky-Pudlak syndrome (HPS) consists of a set of human autosomal recessive disorders, with symptoms resulting from defects in genes required for protein…”
Get more information

The enhancer of polycomb gene of Drosophila encodes a chromatin protein conserved in yeast and mammals by Stankunas, K, Berger, J, Ruse, C, Sinclair, D A, Randazzo, F, Brock, H W

“…The Polycomb group of genes in Drosophila are homeotic switch gene regulators that maintain homeotic gene repression through a possible chromatin regulatory…”
Get full text

Enhancer of Polycomb is a suppressor of position-effect variegation in Drosophila melanogaster by Sinclair, D.A.R. (Simon Fraser University, Burnaby, British Columbia, Canada), Clegg, N.J, Antonchuk, J, Milne, T.A, Stankunas, K, Ruse, C, Grigliatti, T.A, Kassis, J.A, Brock, H.W

“…Polycomb group (PcG) genes of Drosophila are negative regulators of homeotic gene expression required for maintenance of determination. Sequence similarity…”
Get full text

INVESTIGATION OF THE NATURE OF P-INDUCED MALE RECOMBINATION IN DROSOPHILA MELANOGASTER by Sinclair, Donald A. R, Grigliatti, Thomas A

“…The present study consists of an investigation of P-induced male recombination in Drosophila melanogaster from a number of perspectives. In an initial set of…”
Get full text

Different patterns of gene silencing in position-effect variegation by Lloyd, Vett K, Dyment, David, Sinclair, Donald A R, Grigliatti, Thomas A

“…Position-effect variegation (PEV) results when a fully functional gene is moved from its normal position to a position near to a broken…”
Get more information

Homeodomain-interacting protein kinase by Wang, Simon J. H, Sinclair, Donald A. R, Kim, Hae-Yoon, Kinsey, Stephen D, Yoo, Byoungjoo, Shih, Claire R. Y, Wong, Kenneth K. L, Krieger, Charles, Harden, Nicholas, Verheyen, Esther M

“…Homeodomain-interacting protein kinases (Hipks) have been previously associated with cell proliferation and cancer, however, their effects in the nervous…”
Get full text

Recovery and characterization of temperature-sensitive mutations affecting adult viability in Drosophila melanogaster by Homyk, T. Jr, Sinclair, D.A.R, Wong, D.T.L, Grigliatti, T.A

“…Temperature-sensitive (ts) autonomous cell-lethal mutations have been used extensively to study important developmental phenomena, such as pattern formation,…”
Get full text

Genetic and developmental analysis of a temperature-sensitive minute mutation of Drosophila melanogaster by Sinclair, D.A.R, Suzuki, D.T, Grigliatti, T.A

“…A temperature-sensitive (ts) third chromosome Minute (M) mutation, designated Q-III, has been recovered and characterized. Q-III heterozygotes raised at 29…”
Get full text

A Genetic and Molecular Characterization of Two Proximal Heterochromatic Genes on Chromosome 3 of Drosophila melanogaster by Schulze, Sandra R, Sinclair, Donald A R, Fitzpatrick, Kathleen A, Honda, Barry M

“…Heterochromatin comprises a transcriptionally repressive chromosome compartment in the eukaryotic nucleus; this is exemplified by the silencing effect it has…”
Get full text

The Additional sex combs gene of Drosophila encodes a chromatin protein that binds to shared and unique Polycomb group sites on polytene chromosomes by Sinclair, D A, Milne, T A, Hodgson, J W, Shellard, J, Salinas, C A, Kyba, M, Randazzo, F, Brock, H W

“…The Additional sex combs (Asx) gene of Drosophila is a member of the Polycomb group of genes, which are required for maintenance of stable repression of…”
Get full text

Interactions of polyhomeotic with Polycomb group genes of Drosophila melanogaster by Cheng, N.N, Sinclair, D.A.R, Campbell, R.B, Brock, H.W

“…The Polycomb (Pc) group genes of Drosophila are negative regulators of homeotic genes, but individual loci have pleiotropic phenotypes. It has been suggested…”
Get full text

Genetic analysis of the additional sex combs locus of Drosophila melanogaster by Sinclair, D.A.R. (University of British Columbia, Vancouver, British Columbia, Canada), Campbell, R.B, Nicholls, F, Slade, E, Brock, H.W

“…Additional sex combs (Asx) is a member of the Polycomb group of genes, which are thought to be required for maintenance of chromatin structure. To better…”
Get full text

Genetic interactions and dosage effects of Polycomb group genes of Drosophila by Campbell, R B, Sinclair, D A, Couling, M, Brock, H W

“…The Polycomb (Pc) group of genes are required for maintenance of cell determination in Drosophila melanogaster. At least 11 Pc group genes have been described…”
Get more information