Search Results - "Sinclair, Christopher"

Quantifying fat replacement of muscle by quantitative MRI in muscular dystrophy by Burakiewicz, Jedrzej, Sinclair, Christopher D. J., Fischer, Dirk, Walter, Glenn A., Kan, Hermien E., Hollingsworth, Kieren G.

“…The muscular dystrophies are rare orphan diseases, characterized by progressive muscle weakness: the most common and well known is Duchenne muscular dystrophy…”
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MRI biomarker assessment of neuromuscular disease progression: a prospective observational cohort study by Morrow, Jasper M, FRACP, Sinclair, Christopher D J, PhD, Fischmann, Arne, MD, Machado, Pedro M, MD, Reilly, Mary M, Prof, Yousry, Tarek A, Prof, Thornton, John S, PhD, Hanna, Michael G, Prof

“…Summary Background A substantial impediment to progress in trials of new therapies in neuromuscular disorders is the absence of responsive outcome measures…”
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Quantitative muscle MRI as an assessment tool for monitoring disease progression in LGMD2I: a multicentre longitudinal study by Willis, Tracey A, Hollingsworth, Kieren G, Coombs, Anna, Sveen, Marie-Louise, Andersen, Søren, Stojkovic, Tanya, Eagle, Michelle, Mayhew, Anna, de Sousa, Paulo L, Dewar, Liz, Morrow, Jasper M, Sinclair, Christopher D J, Thornton, John S, Bushby, Kate, Lochmüller, Hanns, Hanna, Michael G, Hogrel, Jean-Yves, Carlier, Pierre G, Vissing, John, Straub, Volker

“…Outcome measures for clinical trials in neuromuscular diseases are typically based on physical assessments which are dependent on patient effort, combine the…”
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Upper Limb Evaluation in Duchenne Muscular Dystrophy: Fat-Water Quantification by MRI, Muscle Force and Function Define Endpoints for Clinical Trials by Ricotti, Valeria, Evans, Matthew R B, Sinclair, Christopher D J, Butler, Jordan W, Ridout, Deborah A, Hogrel, Jean-Yves, Emira, Ahmed, Morrow, Jasper M, Reilly, Mary M, Hanna, Michael G, Janiczek, Robert L, Matthews, Paul M, Yousry, Tarek A, Muntoni, Francesco, Thornton, John S

“…A number of promising experimental therapies for Duchenne muscular dystrophy (DMD) are emerging. Clinical trials currently rely on invasive biopsies or…”
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Skeletal muscle MRI differentiates SBMA and ALS and correlates with disease severity by Klickovic, Uros, Zampedri, Luca, Sinclair, Christopher D.J, Wastling, Stephen J, Trimmel, Karin, Howard, Robin S, Malaspina, Andrea, Sharma, Nikhil, Sidle, Katie, Emira, Ahmed, Shah, Sachit, Yousry, Tarek A, Hanna, Michael G, Greensmith, Linda, Morrow, Jasper M, Thornton, John S, Fratta, Pietro

“…OBJECTIVETo investigate the use of muscle MRI for the differential diagnosis and as a disease progression biomarker for 2 major forms of motor neuron…”
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Validation of MRC Centre MRI calf muscle fat fraction protocol as an outcome measure in CMT1A by Morrow, Jasper M, Evans, Matthew R.B, Grider, Tiffany, Sinclair, Christopher D.J, Thedens, Daniel, Shah, Sachit, Yousry, Tarek A, Hanna, Michael G, Nopoulos, Peggy, Thornton, John S, Shy, Michael E, Reilly, Mary M

“…OBJECTIVETo translate the quantitative MRC Centre MRI protocol in Charcot-Marie-Tooth disease type 1A (CMT1A) to a second site; validate its responsiveness in…”
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Quantitative magnetic resonance imaging in limb-girdle muscular dystrophy 2I: a multinational cross-sectional study by Willis, Tracey A, Hollingsworth, Kieren G, Coombs, Anna, Sveen, Marie-Louise, Andersen, Soren, Stojkovic, Tanya, Eagle, Michelle, Mayhew, Anna, de Sousa, Paulo Loureiro, Dewar, Liz, Morrow, Jasper M, Sinclair, Christopher D J, Thornton, John S, Bushby, Kate, Lochmuller, Hanns, Hanna, Michael G, Hogrel, Jean-Yves, Carlier, Pierre G, Vissing, John, Straub, Volker

“…We conducted a prospective multinational study of muscle pathology using magnetic resonance imaging (MRI) in patients with limb-girdle muscular dystrophy 2I…”
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Reproducibility, and age, body-weight and gender dependency of candidate skeletal muscle MRI outcome measures in healthy volunteers by Morrow, Jasper M., Sinclair, Christopher D. J., Fischmann, Arne, Reilly, Mary M., Hanna, Michael G., Yousry, Tarek A., Thornton, John S.

“…Objectives Quantitative magnetic resonance imaging (MRI) can potentially meet the pressing need for objective, sensitive, reproducible outcome measures in…”
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Longitudinal Changes in MRI Muscle Morphometry and Composition in People With Inclusion Body Myositis by Laurent, Didier, Riek, Jon, Sinclair, Christopher D.J., Houston, Parul, Roubenoff, Ronenn, Papanicolaou, Dimitris A., Nagy, Attila, Pieper, Steve, Yousry, Tarek A., Hanna, Michael G., Thornton, John S., Machado, Pedro M.

“…BACKGROUND AND OBJECTIVESLimited data suggest that quantitative MRI (qMRI) measures have potential to be used as trial outcome measures in sporadic inclusion…”
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EXTREMAL LAWS FOR THE REAL GINIBRE ENSEMBLE by Rider, Brian, Sinclair, Christopher D.

“…In this paper we introduce a new multilevel Monte Carlo (MLMC) estimator for multi-dimensional SDEs driven by Brownian motions. Giles has previously shown that…”
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Muscle MRI reveals distinct abnormalities in genetically proven non-dystrophic myotonias by Morrow, Jasper M, Matthews, Emma, Raja Rayan, Dipa L, Fischmann, Arne, Sinclair, Christopher D.J, Reilly, Mary M, Thornton, John S, Hanna, Michael G, Yousry, Tarek A

“…Abstract We assessed the presence, frequency and pattern of MRI abnormalities in non-dystrophic myotonia patients. We reviewed T1-weighted and STIR…”
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Development of MRC Centre MRI calf muscle fat fraction protocol as a sensitive outcome measure in Hereditary Sensory Neuropathy Type 1 by Kugathasan, Umaiyal, Evans, Matthew R B, Morrow, Jasper M, Sinclair, Christopher D J, Thornton, John S, Yousry, Tarek A, Hornemann, Thorsten, Suriyanarayanan, Saranya, Owusu-Ansah, Khadijah, Lauria, Giuseppe, Lombardi, Raffaella, Polke, James M, Wilson, Emma, Bennett, David L H, Houlden, Henry, Hanna, Michael G, Blake, Julian C, Laura, Matilde, Reilly, Mary M

“…ObjectivesHereditary sensory neuropathy type 1 (HSN1) is a rare, slowly progressive neuropathy causing profound sensory deficits and often severe motor loss…”
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Muscle magnetic resonance imaging in congenital myasthenic syndromes by Finlayson, Sarah, Morrow, Jasper M., Rodriguez Cruz, Pedro M., Sinclair, Christopher D.J., Fischmann, Arne, Thornton, John S., Knight, Steve, Norbury, Ray, White, Mel, Al-hajjar, Michal, Carboni, Nicola, Jayawant, Sandeep, Robb, Stephanie A., Yousry, Tarek A., Beeson, David, Palace, Jacqueline

“…ABSTRACT Introduction In this study we investigated muscle magnetic resonance imaging in congenital myasthenic syndromes (CMS). Methods Twenty‐six patients…”
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MRI quantifies lumbosacral nerve root and sciatic nerve hypertrophy in chronic inflammatory demyelinating polyradiculoneuropathy by Shah, Sachit, Morrow, Jasper M., Sinclair, Christopher D.J., Reilly, Mary M., Thornton, John S., Lunn, Michael P., Yousry, Tarek A.

“…•Quantitative MRI measures reveal lumbosacral nerve root hypertrophy in CIDP patients.•These MRI measures also demonstrate sciatic nerve hypertrophy in this…”
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Extra-ocular muscle MRI in genetically-defined mitochondrial disease by Pitceathly, Robert D. S., Morrow, Jasper M., Sinclair, Christopher D. J., Woodward, Cathy, Sweeney, Mary G., Rahman, Shamima, Plant, Gordon T., Ali, Nadeem, Bremner, Fion, Davagnanam, Indran, Yousry, Tarek A., Hanna, Michael G., Thornton, John S.

“…Objectives Conventional and quantitative MRI was performed in patients with chronic progressive external ophthalmoplegia (CPEO), a common manifestation of…”
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Simultaneous T2 and lipid quantitation using IDEAL-CPMG by Janiczek, Robert L., Gambarota, Giulio, Sinclair, Christopher D. J., Yousry, Tarek A., Thornton, John S., Golay, Xavier, Newbould, Rexford D.

“…Muscle damage, edema, and fat infiltration are hallmarks of a range of neuromuscular diseases. The T2 of water, T2,w, in muscle lengthens with both myocellular…”
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Quantitative magnetization transfer in in vivo healthy human skeletal muscle at 3 T by Sinclair, Christopher D. J., Samson, Rebecca S., Thomas, David L., Weiskopf, Nikolaus, Lutti, Antoine, Thornton, John S., Golay, Xavier

“…The value of quantitative MR methods as potential biomarkers in neuromuscular disease is being increasingly recognized. Previous studies of the magnetization…”
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Improved anatomical reproducibility in quantitative lower-limb muscle MRI by Fischmann, Arne, Morrow, Jasper M., Sinclair, Christopher D.J., Reilly, Mary M., Hanna, Michael G., Yousry, Tarek, Thornton, John S.

“…Purpose To compare the influence of two limb positions and slice prescription using scout‐image–based and surface‐anatomy–based methods on the reproducibility…”
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Stability and sensitivity of water T 2 obtained with IDEAL-CPMG in healthy and fat-infiltrated skeletal muscle by Sinclair, Christopher D J, Morrow, Jasper M, Janiczek, Robert L, Evans, Matthew R B, Rawah, Elham, Shah, Sachit, Hanna, Michael G, Reilly, Mary M, Yousry, Tarek A, Thornton, John S

“…Quantifying muscle water T (T -water) independently of intramuscular fat content is essential in establishing T -water as an outcome measure for imminent new…”
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Stability and sensitivity of water T2 obtained with IDEAL-CPMG in healthy and fat-infiltrated skeletal muscle by Sinclair, Christopher D.J., Morrow, Jasper M., Janiczek, Robert L., Evans, Matthew R.B., Rawah, Elham, Shah, Sachit, Hanna, Michael G., Reilly, Mary M., Yousry, Tarek A., Thornton, John S.

“…Quantifying muscle water T2 (T2‐water) independently of intramuscular fat content is essential in establishing T2‐water as an outcome measure for imminent new…”
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