Search Results - "Sinai, Claire"

Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells by Reitman, Zachary J., Paolella, Brenton R., Bergthold, Guillaume, Pelton, Kristine, Becker, Sarah, Jones, Robert, Sinai, Claire E., Malkin, Hayley, Huang, Ying, Grimmet, Leslie, Herbert, Zachary T., Sun, Yu, Weatherbee, Jessica L., Alberta, John A., Daley, John F., Rozenblatt-Rosen, Orit, Condurat, Alexandra L., Qian, Kenin, Khadka, Prasidda, Segal, Rosalind A., Haas-Kogan, Daphne, Filbin, Mariella G., Suva, Mario L., Regev, Aviv, Stiles, Charles D., Kieran, Mark W., Goumnerova, Liliana, Ligon, Keith L., Shalek, Alex K., Bandopadhayay, Pratiti, Beroukhim, Rameen

“…Pilocytic astrocytoma (PA), the most common childhood brain tumor, is a low-grade glioma with a single driver BRAF rearrangement. Here, we perform scRNAseq in…”
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Rethinking childhood ependymoma: a retrospective, multi-center analysis reveals poor long-term overall survival by Marinoff, Amanda E., Ma, Clement, Guo, Dongjing, Snuderl, Matija, Wright, Karen D., Manley, Peter E., Al-Sayegh, Hasan, Sinai, Claire E., Ullrich, Nicole J., Marcus, Karen, Haas-Kogan, Daphne, Goumnerova, Liliana, London, Wendy B., Kieran, Mark W., Chi, Susan N., Fangusaro, Jason, Bandopadhayay, Pratiti

“…Ependymoma is the third most common brain tumor in children, but there is a paucity of large studies with more than 10 years of follow-up examining the…”
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Liquid biopsy detection of genomic alterations in pediatric brain tumors from cell-free DNA in peripheral blood, CSF, and urine by Pagès, Mélanie, Rotem, Denisse, Gydush, Gregory, Reed, Sarah, Rhoades, Justin, Ha, Gavin, Lo, Christopher, Fleharty, Mark, Duran, Madeleine, Jones, Robert, Becker, Sarah, Haller, Michaela, Sinai, Claire E, Goumnerova, Liliana, Golub, Todd R, Love, J Christopher, Ligon, Keith L, Wright, Karen D, Adalsteinsson, Viktor A, Beroukhim, Rameen, Bandopadhayay, Pratiti

“…Abstract Background The ability to identify genetic alterations in cancers is essential for precision medicine; however, surgical approaches to obtain brain…”
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Molecular Alterations in Pediatric Low-Grade Gliomas That Led to Death by Ahrendsen, Jared T, Sinai, Claire, Meredith, David M, Malinowski, Seth W, Cooney, Tabitha M, Bandopadhayay, Pratiti, Ligon, Keith L, Alexandrescu, Sanda

“…Abstract Pediatric low-grade gliomas (PLGGs) have excellent long-term survival, but death can occasionally occur. We reviewed all PLGG-related deaths between…”
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Prospective feasibility and safety assessment of surgical biopsy for patients with newly diagnosed diffuse intrinsic pontine glioma by Gupta, Nalin, Goumnerova, Liliana C, Manley, Peter, Chi, Susan N, Neuberg, Donna, Puligandla, Maneka, Fangusaro, Jason, Goldman, Stewart, Tomita, Tadanori, Alden, Tord, DiPatri, Arthur, Rubin, Joshua B, Gauvain, Karen, Limbrick, David, Leonard, Jeffrey, Geyer, J Russel, Leary, Sarah, Browd, Samuel, Wang, Zhihong, Sood, Sandeep, Bendel, Anne, Nagib, Mahmoud, Gardner, Sharon, Karajannis, Matthias A, Harter, David, Ayyanar, Kanyalakshmi, Gump, William, Bowers, Daniel C, Weprin, Bradley, MacDonald, Tobey J, Aguilera, Dolly, Brahma, Barunashish, Robison, Nathan J, Kiehna, Erin, Krieger, Mark, Sandler, Eric, Aldana, Philipp, Khatib, Ziad, Ragheb, John, Bhatia, Sanjiv, Mueller, Sabine, Banerjee, Anu, Bredlau, Amy-Lee, Gururangan, Sri, Fuchs, Herbert, Cohen, Kenneth J, Jallo, George, Dorris, Kathleen, Handler, Michael, Comito, Melanie, Dias, Mark, Nazemi, Kellie, Baird, Lissa, Murray, Jeff, Lindeman, Neal, Hornick, Jason L, Malkin, Hayley, Sinai, Claire, Greenspan, Lianne, Wright, Karen D, Prados, Michael, Bandopadhayay, Pratiti, Ligon, Keith L, Kieran, Mark W

“…Diagnosis of diffuse intrinsic pontine glioma (DIPG) has relied on imaging studies, since the appearance is pathognomonic, and surgical risk was felt to be…”
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Immunophenotyping of pediatric brain tumors: correlating immune infiltrate with histology, mutational load, and survival and assessing clonal T cell response by Plant, Ashley S., Koyama, Shohei, Sinai, Claire, Solomon, Isaac H., Griffin, Gabriel K., Ligon, Keith L., Bandopadhayay, Pratiti, Betensky, Rebecca, Emerson, Ryan, Dranoff, Glenn, Kieran, Mark W., Ritz, Jerome

“…There is little known regarding the immune infiltrate present in pediatric brain tumors and how this compares to what is known about histologically similar…”
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ALK Amplification and Rearrangements Are Recurrent Targetable Events in Congenital and Adult Glioblastoma by Blandin, Anne-Florence, Giglio, Ross, Graham, Maya Srikanth, Garcia, Guadalupe, Malinowski, Seth, Woods, Jared K, Ramkissoon, Shakti, Ramkissoon, Lori, Dubois, Frank, Schoolcraft, Kathleen, Tsai, Jessica, Wang, Dayle, Jones, Robert, Vogelzang, Jayne, Pelton, Kristine, Becker, Sarah, Watkinson, Fiona, Sinai, Claire, Cohen, Elizabeth F, Booker, Matthew A, Tolstorukov, Michael Y, Haemels, Veerle, Goumnerova, Liliana, Wright, Karen, Kieran, Mark, Fehnel, Katie, Reardon, David, Tauziede-Espariat, Arnault, Lulla, Rishi, Carcamo, Benjamin, Chaleff, Stanley, Charest, Alain, De Smet, Frederik, Ligon, Azra H, Dubuc, Adrian, Pages, Melanie, Varlet, Pascale, Wen, Patrick Y, Alexander, Brian M, Chi, Susan, Alexandrescu, Sanda, Kittler, Ralf, Bachoo, Robert, Bandopadhayay, Pratiti, Beroukhim, Rameen, Ligon, Keith L

“…Anaplastic lymphoma kinase (ALK) aberrations have been identified in pediatric-type infant gliomas, but their occurrence across age groups, functional effects,…”
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BIOM-61. FUNCTIONAL DIAGNOSTIC TESTING OF LIVE-CELL DRUG RESPONSE USING 3D PATIENT DERIVED GLIOBLASTOMA SPHEROIDS ON THE INCUCYTE PLATFORM by Malinowski, Seth, Touat, Mehdi, Stockslager, Max, Giglio, Ross, Geduldig, Jack, Sinai, Claire, Pelton, Kristine, Reardon, David, Wen, Patrick, Chow, Kin Hoe, Manalis, Scott, Ligon, Keith

“…Abstract Three-dimensional patient derived cultures hold great potential for use as personalized functional diagnostics, enabling more accurate preclinical…”
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Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors by Ramkissoon, Shakti H, Bandopadhayay, Pratiti, Hwang, Jaeho, Ramkissoon, Lori A, Greenwald, Noah F, Schumacher, Steven E, O'Rourke, Ryan, Pinches, Nathan, Ho, Patricia, Malkin, Hayley, Sinai, Claire, Filbin, Mariella, Plant, Ashley, Bi, Wenya Linda, Chang, Michael S, Yang, Edward, Wright, Karen D, Manley, Peter E, Ducar, Matthew, Alexandrescu, Sanda, Lidov, Hart, Delalle, Ivana, Goumnerova, Liliana C, Church, Alanna J, Janeway, Katherine A, Harris, Marian H, MacConaill, Laura E, Folkerth, Rebecca D, Lindeman, Neal I, Stiles, Charles D, Kieran, Mark W, Ligon, Azra H, Santagata, Sandro, Dubuc, Adrian M, Chi, Susan N, Beroukhim, Rameen, Ligon, Keith L

“…Clinical genomics platforms are needed to identify targetable alterations, but implementation of these technologies and best practices in routine clinical…”
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Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma by Bandopadhayay, Pratiti, Piccioni, Federica, O’Rourke, Ryan, Ho, Patricia, Gonzalez, Elizabeth M., Buchan, Graham, Qian, Kenin, Gionet, Gabrielle, Girard, Emily, Coxon, Margo, Rees, Matthew G., Brenan, Lisa, Dubois, Frank, Shapira, Ofer, Greenwald, Noah F., Pages, Melanie, Balboni Iniguez, Amanda, Paolella, Brenton R., Meng, Alice, Sinai, Claire, Roti, Giovanni, Dharia, Neekesh V., Creech, Amanda, Tanenbaum, Benjamin, Khadka, Prasidda, Tracy, Adam, Tiv, Hong L., Hong, Andrew L., Coy, Shannon, Rashid, Rumana, Lin, Jia-Ren, Cowley, Glenn S., Lam, Fred C., Goodale, Amy, Lee, Yenarae, Schoolcraft, Kathleen, Vazquez, Francisca, Hahn, William C., Tsherniak, Aviad, Bradner, James E., Yaffe, Michael B., Milde, Till, Pfister, Stefan M., Qi, Jun, Schenone, Monica, Carr, Steven A., Ligon, Keith L., Kieran, Mark W., Santagata, Sandro, Olson, James M., Gokhale, Prafulla C., Jaffe, Jacob D., Root, David E., Stegmaier, Kimberly, Johannessen, Cory M., Beroukhim, Rameen

“…BET-bromodomain inhibition (BETi) has shown pre-clinical promise for MYC-amplified medulloblastoma. However, the mechanisms for its action, and ultimately for…”
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HGG-41. STRUCTURAL VARIANT DRIVERS IN PEDIATRIC HIGH-GRADE GLIOMA by Dubois, Frank, Shapira, Ofer, Greenwald, Noah, Zack, Travis, Tsai, Jessica W, Harutyunyan, Ashot S, Kumar, Kiran, Sinai, Claire, Malkin, Hayley, Jones, Robert, Ho, Patricia, O’Rourke, Ryan, Kang, Kyung S, Jabado, Nada, Kieran, Mark W, Ligon, Keith, Beroukhim, Rameen, Bandopadhayay, Pratiti

“…Abstract BACKGROUND Driver single nucleotide variants (SNV) and somatic copy number aberrations (SCNA) of pediatric high-grade glioma (pHGGs), including…”
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IMMU-08. IMMUNOPHENOTYPING OF PEDIATRIC BRAIN TUMORS: CORRELATING IMMUNE INFILTRATE WITH HISTOLOGY, MUTATIONAL LOAD, AND SURVIVAL by Plant, Ashley, Koyama, Shohei, Sinai, Claire, Solomon, Isaac, Griffin, Gabriel, Dranoff, Glenn, Kieran, Mark, Ritz, Jerome

“…There is little known regarding the immune infiltrate present in pediatric brain tumors and how this compares to what is known about histologically similar…”
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HGG-60. Structural variants shape driver combinations and outcomes in pediatric high-grade glioma by Dubois, Frank, Shapira, Ofer, Greenwald, Noah, Zack, Travis, Wala, Jeremiah, Tsai, Jessica, Crane, Alexander, Baguette, Audrey, Hadjadj, Djihad, Harutyunyan, Ashot, Kumar, Kiran, Blattner-Johnson, Mirjam, Vogelzang, Jayne, Sousa, Cecilia, Kang, Kyung Shin, Sinai, Claire, Wang, Dayle, Khadka, Prasidda, Malkin, Hayley, Ho, Patricia, O'Rourke, Ryan, Zhang, Shu, Gold, Rose, Deng, Davy, Serrano, Jonathan, Snuderl, Matija, Jones, Chris, Wright, Karen, Chi, Susan, Grill, Jacques, Kleinman, Claudia, Goumnerova, Liliana, Jabado, Nada, Jones, David, Kieran, Mark, Ligon, Keith, Beroukhim, Rameen, Bandopadhayay, Pratiti

“…Abstract Pediatric high-grade gliomas (pHGGs), encompassing hemispheric and diffuse midline gliomas (DMGs), remain a devastating disease. The last decade has…”
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IMMU-04. IMMUNOPHENOTYPING OF PEDIATRIC BRAIN TUMORS: CORRELATING IMMUNE INFILTRATE WITH HISTOLOGY, MUTATIONAL LOAD, AND SURVIVAL AND ASSESSING CLONAL T CELL RESPONSE by Plant, Ashley, Koyama, Shohei, Sinai, Claire, Solomon, Isaac, Griffin, Gabriel, Betensky, Rebecca, Emerson, Ryan, Dranoff, Glenn, Kieran, Mark, Ritz, Jerome

“…There is little known regarding the immune infiltrate present in pediatric brain tumors and how this compares to what is known about histologically similar…”
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Abstract 3647: Single cell RNA sequencing reveals mitogenic and progenitor gene programs inBRAF-rearranged pilocytic astrocytomas by Reitman, Zachary J., Paolella, Brenton, Bergthold, Guillaume, Pelton, Kristine, Jones, Robert, Becker, Sarah, Sinai, Claire E., Malkin, Haley, Huang, Ying, Grimmett, Leslie, Herbert, Zachary T., Sun, Yu, Weatherbee, Jessica, Alberta, John, Daley, John, Rozenblatt-Rosen, Orit, Segal, Rosalind, Haas-Kogan, Daphne, Filbin, Mariella G., Suva, Mario L., Regev, Aviv, Stiles, Charles, Kieran, Mark W., Goumnerova, Liliana, Ligon, Keith L., Shalek, Alex K., Bandopadhayay, Pratiti, Beroukhim, Rameen

“…Abstract Single-cell RNA sequencing (scRNAseq) has been performed across a range of intermediate to high-grade gliomas that each harbor multiple driver…”
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TMOD-03. PAN-CANCER ANALYSIS OF ORTHOTOPIC PATIENT DERIVED XENOGRAFTS FROM BRAIN METASTASES by Zeng, Yu, Pelton, Kristine, Yerrum, Smitha, Kao, Pei-Lun, Sinai, Claire, Tran, Tony, Sinha, Rileen, Shetty, Aniket, Tolstorukov, Michael, Jaber, Aliya, Freitas, Dylan, Pisano, William, Verselis, Sigitas J, Herbert, Zach T, Lin, Nancy, Zhao, Jean J, Weinstock, David M, Chukwueke, Ugonma, Aizer, Ayal A, Chiocca, E Antonio, Bi, Wenya Linda, Wen, Patrick, Lee, Eudocia, Nayak, Lakshmi, Meredith, David, Santagata, Sandro, Chow, Kin Hoe, Ligon, Keith

“…Abstract Brain metastases (BM) are a leading cause of cancer death and prognosis remains poor despite treatment advances at other sites. Models are central to…”
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LG-24BRAF ALTERATIONS IN PEDIATRIC PILOCYTIC ASTROCYTOMAS WITH RECURRENCES/PROGRESSION by Rao, Amulya Nageswara, Kohorst, Mira, Warad, Deepti, Ligon, Keith, Daniels, David, Raghunathan, Aditya, Sinai, Claire, Ligon, Azra, Giannini, Caterina

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IMMU-23. IMMUNOPHENOTYPING OF PEDIATRIC BRAIN TUMORS: CORRELATING IMMUNE INFILTRATE WITH HISTOLOGY, MUTATIONAL LOAD, AND SURVIVAL AND ASSESSING CLONAL T CELL RESPONSE by Plant, Ashley S., Koyama, Shohei, Sinai, Claire, Solomon, Isaac, Griffin, Gabriel, Betensky, Rebecca, Emerson, Ryan, Dranoff, Glenn, Kieran, Mark W., Ritz, Jerome

“…There is little known regarding the immune infiltrate present in pediatric brain tumors and how this compares to what is known about histologically similar…”
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LGG-05. SINGLE CELL RNA SEQUENCING REVEALS MITOGENIC AND PROGENITOR GENE PROGRAMS IN BRAF-REARRANGED PILOCYTIC ASTROCYTOMAS by Reitman, Zachary, Paolella, Brenton, Bergthold, Guillaume, Pelton, Kristine, Becker, Sarah, Jones, Robert, Sinai, Claire, Malkin, Hayley, Huang, Ying, Grimmet, Leslie, Herbert, Zachary, Sun, Yu, Weatherbee, Jessica, Qian, Kenin, Condurat, Alexandra-Larisa, Alberta, John, Daley, John, Rozenblatt-Rozen, Orit, Segal, Rosalind, Haas-Kogan, Daphne, Filbin, Mariella, Suva, Mario, Regev, Aviv, Stiles, Charles, Kieran, Mark, Goumnerova, Liliana, Ligon, Keith, Shalek, Alex, Beroukhim, Rameen, Bandopadhayay, Pratiti

“…Abstract Pilocytic astrocytoma (PA) is the most common pediatric low-grade glioma. While PAs exhibit a favorable prognosis compared to higher-grade gliomas,…”
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LGG-05. SINGLE-CELL RNA SEQUENCING OF PEDIATRIC LOW-GRADE GLIOMAS REVEALS INTRATUMORAL HETEROGENEITY by Paolella, Brenton, Bandopadhayay, Pratiti, Bergthold, Guillaume, Shalek, Alex, Pelton, Kristine, Ramkissoon, Shakti, Sinai, Claire, Malkin, Hayley, Herbert, Zach, Sun, Yu, Alberta, John, Brown, Meredith, Daley, John, Lazo-Kallanian, Suzan, Goumnerova, Liliana, Kieran, Mark, Ligon, Keith, Beroukhim, Rameen

“…Pediatric low-grade gliomas (PLGGs) are slow growing tumors that result in neurologic defects due to both disease burden and therapeutic complications. We have…”
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