Search Results - "Sin Lo, Ken"

Multimodal CRISPR perturbations of GWAS loci associated with coronary artery disease in vascular endothelial cells by Wünnemann, Florian, Fotsing Tadjo, Thierry, Beaudoin, Mélissa, Lalonde, Simon, Lo, Ken Sin, Kleinstiver, Benjamin P, Lettre, Guillaume

“…Genome-wide association studies have identified >250 genetic variants associated with coronary artery disease (CAD), but the causal variants, genes and…”
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Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes by Gagné, Jean-Philippe, Isabelle, Maxim, Lo, Ken Sin, Bourassa, Sylvie, Hendzel, Michael J, Dawson, Valina L, Dawson, Ted M, Poirier, Guy G

“…Poly(ADP-ribose) (pADPr) is a polymer assembled from the enzymatic polymerization of the ADP-ribosyl moiety of NAD by poly(ADP-ribose) polymerases (PARPs). The…”
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Integrative analysis of vascular endothelial cell genomic features identifies AIDA as a coronary artery disease candidate gene by Lalonde, Simon, Codina-Fauteux, Valérie-Anne, de Bellefon, Sébastian Méric, Leblanc, Francis, Beaudoin, Mélissa, Simon, Marie-Michelle, Dali, Rola, Kwan, Tony, Lo, Ken Sin, Pastinen, Tomi, Lettre, Guillaume

“…Genome-wide association studies (GWAS) have identified hundreds of loci associated with coronary artery disease (CAD) and blood pressure (BP) or hypertension…”
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Variation and impact of polygenic hematologic traits in monogenic sickle cell disease by Pincez, Thomas, Lo, Ken Sin, D'Orengiani, Anne-Laure Pham Hung d'Alexandry, Garrett, Melanie E, Brugnara, Carlo, Ashley-Koch, Allison E, Telen, Marilyn J, Galacteros, Frederic, Joly, Philippe, Bartolucci, Pablo, Lettre, Guillaume

“…Several of the complications observed in sickle cell disease (SCD) are influenced by variation in hematologic traits (HT), such as fetal hemoglobin (HbF) level…”
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Validation of Genome-Wide Polygenic Risk Scores for Coronary Artery Disease in French Canadians by Wünnemann, Florian, Sin Lo, Ken, Langford-Avelar, Alexandra, Busseuil, David, Dubé, Marie-Pierre, Tardif, Jean-Claude, Lettre, Guillaume

“…Coronary artery disease (CAD) represents one of the leading causes of morbidity and mortality worldwide. Given the healthcare risks and societal impacts…”
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PHACTR1 splicing isoforms and eQTLs in atherosclerosis-relevant human cells by Codina-Fauteux, Valérie-Anne, Beaudoin, Mélissa, Lalonde, Simon, Lo, Ken Sin, Lettre, Guillaume

“…Genome-wide association studies (GWAS) have identified a variant (rs9349379) at the phosphatase and actin regulator 1 (PHACTR1) locus that is associated with…”
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Nonsense Mutations in BAG3 are Associated With Early-Onset Dilated Cardiomyopathy in French Canadians by Chami, Nathalie, MS, Tadros, Rafik, MD, PhD, Lemarbre, François, BS, Lo, Ken Sin, BS, Beaudoin, Mélissa, MS, Robb, Laura, MS, Labuda, Damian, PhD, Tardif, Jean-Claude, MD, Racine, Normand, MD, Talajic, Mario, MD, Lettre, Guillaume, PhD

“…Abstract Background Dilated cardiomyopathy (DCM) is a major cause of heart failure that may require heart transplantation. Approximately one third of DCM cases…”
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Variants at the APOE /C1/C2/C4 Locus Modulate Cholesterol Efflux Capacity Independently of High-Density Lipoprotein Cholesterol by Low-Kam, Cécile, Rhainds, David, Lo, Ken Sin, Barhdadi, Amina, Boulé, Marie, Alem, Sonia, Pedneault-Gagnon, Valérie, Rhéaume, Eric, Dubé, Marie-Pierre, Busseuil, David, Hegele, Robert A, Lettre, Guillaume, Tardif, Jean-Claude

“…Background Macrophage cholesterol efflux to high-density lipoproteins ( HDLs ) is the first step of reverse cholesterol transport. The cholesterol efflux…”
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Genetic association analysis highlights new loci that modulate hematological trait variation in Caucasians and African Americans by Lo, Ken Sin, Wilson, James G, Lange, Leslie A, Folsom, Aaron R, Galarneau, Geneviève, Ganesh, Santhi K, Grant, Struan F. A, Keating, Brendan J, McCarroll, Steven A, Mohler III, Emile R, O'Donnell, Christopher J, Palmas, Walter, Tang, Weihong, Tracy, Russell P, Reiner, Alexander P, Lettre, Guillaume

“…Red blood cell, white blood cell, and platelet measures, including their count, sub-type and volume, are important diagnostic and prognostic clinical…”
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Pooled DNA Resequencing of 68 Myocardial Infarction Candidate Genes in French Canadians by Beaudoin, Mélissa, Lo, Ken Sin, N’Diaye, Amidou, Rivas, Manuel A, Dubé, Marie-Pierre, Laplante, Nathalie, Phillips, Michael S, Rioux, John D, Tardif, Jean-Claude, Lettre, Guillaume

“…BACKGROUND—Familial history is a strong risk factor for coronary artery disease (CAD), especially for early-onset myocardial infarction (MI). Several genes and…”
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Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease by Rivas, Manuel A, Daly, Mark J, Beaudoin, Mélissa, Gardet, Agnes, Stevens, Christine, Sharma, Yashoda, Zhang, Clarence K, Boucher, Gabrielle, Ripke, Stephan, Ellinghaus, David, Burtt, Noel, Fennell, Tim, Kirby, Andrew, Latiano, Anna, Goyette, Philippe, Green, Todd, Halfvarson, Jonas, Haritunians, Talin, Korn, Joshua M, Kuruvilla, Finny, Lagacé, Caroline, Neale, Benjamin, Lo, Ken Sin, Schumm, Phil, Törkvist, Leif, Dubinsky, Marla C, Brant, Steven R, Silverberg, Mark S, Duerr, Richard H, Altshuler, David, Gabriel, Stacey, Lettre, Guillaume, Franke, Andre, D'Amato, Mauro, McGovern, Dermot P B, Cho, Judy H, Rioux, John D, Xavier, Ramnik J

“…Mark Daly, Manuel Rivas and colleagues used next-generation sequencing to study the coding exons of 56 genes from regions previously associated with Crohn's…”
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Myocardial Infarction–Associated SNP at 6p24 Interferes With MEF2 Binding and Associates With PHACTR1 Expression Levels in Human Coronary Arteries by Beaudoin, Mélissa, Gupta, Rajat M, Won, Hong-Hee, Lo, Ken Sin, Do, Ron, Henderson, Christopher A, Lavoie-St-Amour, Claire, Langlois, Simon, Rivas, Daniel, Lehoux, Stephanie, Kathiresan, Sekar, Tardif, Jean-Claude, Musunuru, Kiran, Lettre, Guillaume

“…OBJECTIVE—Coronary artery disease (CAD), including myocardial infarction (MI), is the main cause of death in the world. Genome-wide association studies have…”
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Rare and low-frequency coding variants in CXCR2 and other genes are associated with hematological traits by Auer, Paul L, Teumer, Alexander, Schick, Ursula, O'Shaughnessy, Andrew, Lo, Ken Sin, Chami, Nathalie, Carlson, Chris, de Denus, Simon, Dubé, Marie-Pierre, Haessler, Jeff, Jackson, Rebecca D, Kooperberg, Charles, Perreault, Louis-Philippe Lemieux, Nauck, Matthias, Peters, Ulrike, Rioux, John D, Schmidt, Frank, Turcot, Valérie, Völker, Uwe, Völzke, Henry, Greinacher, Andreas, Hsu, Li, Tardif, Jean-Claude, Diaz, George A, Reiner, Alexander P, Lettre, Guillaume

“…Guillaume Lettre, Alexander Reiner, George Diaz and colleagues use an exome array to identify rare and low-frequency coding variants influencing hematological…”
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Strategies to fine-map genetic associations with lipid levels by combining epigenomic annotations and liver-specific transcription profiles by Lo, Ken Sin, Vadlamudi, Swarooparani, Fogarty, Marie P., Mohlke, Karen L., Lettre, Guillaume

“…Characterization of the epigenome promises to yield the functional elements buried in the human genome sequence, thus helping to annotate non-coding DNA…”
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Whole-genome sequencing in French Canadians from Quebec by Low-Kam, Cécile, Rhainds, David, Lo, Ken Sin, Provost, Sylvie, Mongrain, Ian, Dubois, Anick, Perreault, Sylvie, Robinson, John F., Hegele, Robert A., Dubé, Marie-Pierre, Tardif, Jean-Claude, Lettre, Guillaume

“…Genome-wide association studies (GWAS) have had a tremendous success in the identification of common DNA sequence variants associated with complex human…”
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The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study (vol 11, e1005378, 2015) by Winkler, TW, Justice, AE, Graff, M, Barata, L, Feitosa, MF, Chu, S, Czajkowski, J, Esko, T, Fall, T, Kilpelainen, TO

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Deep Resequencing of GWAS Loci Identifies Rare Variants in CARD9, IL23R and RNF186 That Are Associated with Ulcerative Colitis: e1003723 by Beaudoin, Mélissa, Goyette, Philippe, Boucher, Gabrielle, Lo, Ken Sin, Rivas, Manuel A, Stevens, Christine, Alikashani, Azadeh, Ladouceur, Martin, Ellinghaus, David, Törkvist, Leif, Goel, Gautam, Lagacé, Caroline, Annese, Vito, Bitton, Alain, Begun, Jakob, Brant, Steve R, Bresso, Francesca, Cho, Judy H, Duerr, Richard H, Halfvarson, Jonas, McGovern, Dermot PB, Radford-Smith, Graham, Schreiber, Stefan, Schumm, Philip L, Sharma, Yashoda, Silverberg, Mark S, Weersma, Rinse K, Vermeire, Severine, Franke, Andre, Lettre, Guillaume, Xavier, Ramnik J, Daly, Mark J, Rioux, John D, Consortium, Quebec IBDGenetics, Consortium, NIDDK IBDGenetics, Consortium, International IBDGenetics

“…Genome-wide association studies and follow-up meta-analyses in Crohn's disease (CD) and ulcerative colitis (UC) have recently identified 163 disease-associated…”
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Differential Proteomic Screen To Evidence Proteins Ubiquitinated upon Mitotic Exit in Cell-Free Extract of Xenopus laevis Embryos by Bazile, Franck, Gagné, Jean-Philippe, Mercier, Geneviève, Lo, Ken Sin, Pascal, Aude, Vasilescu, Julian, Figeys, Daniel, Poirier, Guy G, Kubiak, Jacek Z, Chesnel, Franck

“…Post-translational modification of proteins via ubiquitination plays a crucial role in numerous vital functions of the cell. Polyubiquitination is one of the…”
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Optimus Primer: A PCR enrichment primer design program for next-generation sequencing of human exonic regions by Brown, Andrew Mk, Lo, Ken Sin, Guelpa, Paul, Beaudoin, Mélissa, Rioux, John D, Tardif, Jean-Claude, Phillips, Michael S, Lettre, Guillaume

“…Polymerase chain reaction (PCR) remains a simple, flexible, and inexpensive method for enriching genomic regions of interest for next-generation sequencing. In…”
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