Search Results - "Sims, Trevor J"

Phenotypic expression of osteoblast collagen in osteoarthritic bone: production of type I homotrimer by Bailey, Allen J, Sims, Trevor J, Knott, Lynda

“…The metabolism and total amount of the collagen of subchondral bone are increased several fold in osteoathritic femurs compared with controls. We now report…”
Get full text

Biochemical methods for the analysis of tissue-engineered cartilage by Kafienah, Wa'el, Sims, Trevor J

Get more information

quantitative determination of collagen cross-links by Avery, Nicholas C, Sims, Trevor J, Bailey, Allen J

“…The primary functional role of collagen is as a supporting tissue and it is now established that the aggregated forms of the collagen monomers are stabilised…”
Get more information

Three‐dimensional cartilage tissue engineering using adult stem cells from osteoarthritis patients by Kafienah, Wael, Mistry, Sanjay, Dickinson, Sally C., Sims, Trevor J., Learmonth, Ian, Hollander, Anthony P.

“…Objective To determine whether it is possible to engineer 3‐dimensional hyaline cartilage using mesenchymal stem cells derived from the bone marrow (BMSCs) of…”
Get full text

Biochemical markers of the mechanical quality of engineered hyaline cartilage by Kelly, Daniel J, Crawford, Aileen, Dickinson, Sally C, Sims, Trevor J, Mundy, Jenny, Hollander, Anthony P, Prendergast, Patrick J, Hatton, Paul V

“…The aim of this study was to determine whether or not biochemical markers can be used as surrogate measures for the mechanical quality of tissue engineered…”
Get full text

The Role of the α2 Chain in the Stabilization of the Collagen Type I Heterotrimer: A Study of the Type I Homotrimer in oim Mouse Tissues by Miles, Christopher A., Sims, Trevor J., Camacho, Nancy P., Bailey, Allen J.

“…We have previously reported that the fragility of skin, tendon and bone from the oim mouse is related to a significant reduction in the intermolecular…”
Get full text

Biochemical and mechanical properties of subchondral bone in osteoarthritis by Bailey, Allen J, Mansell, Jason P, Sims, Trevor J, Banse, Xavier

“…The subchondral bone has long been known to thicken in osteoarthritis. However, recent evidence has demonstrated that the turnover of the bone is increased…”
Get more information

Maturation of tissue engineered cartilage implanted in injured and osteoarthritic human knees by Hollander, Anthony P, Dickinson, Sally C, Sims, Trevor J, Brun, Paola, Cortivo, Roberta, Kon, Elisaveta, Marcacci, Maurilio, Zanasi, Stefano, Borrione, Anna, De Luca, Claudio, Pavesio, Alessandra, Soranzo, Carlo, Abatangelo, Giovanni

“…The regeneration of damaged organs requires that engineered tissues mature when implanted at sites of injury or disease. We have used new analytic techniques…”
Get more information

Identification of an Intermediate State in the Helix-Coil Degradation of Collagen by Ultraviolet Light by Miles, Christopher A., Sionkowska, Alina, Hulin, Sarah L., Sims, Trevor J., Avery, Nicholas C., Bailey, Allen J.

“…Differential scanning calorimetry has revealed the presence of a new denaturation endotherm at 32 °C following UV irradiation of collagen, compared with 39 °C…”
Get full text

Age related changes in the non-collagenous components of the extracellular matrix of the human lamina cribrosa by Albon, Julie, Karwatowski, Wojciech S S, Easty, David L, Sims, Trevor J, Duance, Victor C

“…AIMS To investigate age related alterations in the non-collagenous components of the human lamina cribrosa. METHODS Fibronectin, elastin, and glial fibrillary…”
Get full text

Effects of in vitro preculture on in vivo development of human engineered cartilage in an ectopic model by Moretti, Matteo, Wendt, David, Dickinson, Sally C, Sims, Trevor J, Hollander, Anthony P, Kelly, Danny J, Prendergast, Patrick J, Heberer, Michael, Martin, Ivan

“…We investigated whether, and under which conditions (i.e., cell-seeding density, medium supplements), in vitro preculture enhances in vivo development of human…”
Get more information

Cruciate ligament laxity and femoral intercondylar notch narrowing in early‐stage knee osteoarthritis by Quasnichka, Helen L., Anderson‐MacKenzie, Janet M., Tarlton, John F., Sims, Trevor J., Billingham, Michael E. J., Bailey, Allen J.

“…Objective The influence of the cruciate ligaments in spontaneous osteoarthritis (OA) is not understood, although ligament rupture is known to cause secondary…”
Get full text

Isolation and characterization of advanced glycation end products derived from the in vitro reaction of ribose and collagen by Paul, R G, Avery, N C, Slatter, D A, Sims, T J, Bailey, A J

“…An amino acid component, NFC-1, when formed in vitro by the reaction of ribose and protein was shown to comprise a complex mixture of high and low molecular…”
Get full text

Quantitative outcome measures of cartilage repair in patients treated by tissue engineering by Dickinson, Sally C, Sims, Trevor J, Pittarello, Leda, Soranzo, Carlo, Pavesio, Alessandra, Hollander, Anthony P

“…Reliable and reproducible outcome measures are essential to assess the efficacy of competing and novel tissue-engineering techniques. The aim of this study was…”
Get more information

Meat tenderness: distribution of molecular species of collagen in bovine muscle by Bailey, A J, Sims, T J

Get more information

Changes in collagen cross-linking in degenerative disc disease and scoliosis by DUANCE, V. C, CREAN, J. K. G, SIMS, T. J, AVERY, N, SMITH, S, MENAGE, J, EISENSTEIN, S. M, ROBERTS, S

“…Biochemical study of the changes in the collagen cross-link profile of human intervertebral discs collected at surgery from patients with either low back pain…”
Get full text

The role of the alpha2 chain in the stabilization of the collagen type I heterotrimer: a study of the type I homotrimer in oim mouse tissues by Miles, Christopher A, Sims, Trevor J, Camacho, Nancy P, Bailey, Allen J

“…We have previously reported that the fragility of skin, tendon and bone from the oim mouse is related to a significant reduction in the intermolecular…”
Get full text

Quantitative analysis of repair tissue biopsies following chondrocyte implantation by Hollander, Anthony P, Dickinson, Sally C, Sims, Trevor J, Soranzo, Carlo, Pavesio, Alessandra

“…Outcome measures for cartilage repair techniques include clinical assessment of functional status, magnetic resonance imaging, mechanical indentation in situ…”
Get more information

Quantitative analysis of collagen and elastin cross-links using a single-column system by Sims, T J, Bailey, A J

“…The separation of both the immature and mature cross-links present in collagen together with the stable cross-links of elastin has been achieved on a single…”
Get more information

An investigation of the biochemical and histological changes in the collagen of the kidney and skeletal muscle in systemic sclerosis by Black, C M, Duance, V C, Sims, T J, Light, N D

“…Changes in the distribution and quantity of different collagen types in some internal organs was determined in tissues from patients with systemic sclerosis…”
Get more information