Search Results - "Sims, Stuart"

Autophagy is a critical regulator of memory CD8(+) T cell formation by Puleston, Daniel J, Zhang, Hanlin, Powell, Timothy J, Lipina, Elina, Sims, Stuart, Panse, Isabel, Watson, Alexander S, Cerundolo, Vincenzo, Townsend, Alain Rm, Klenerman, Paul, Simon, Anna Katharina

“…During infection, CD8(+) T cells initially expand then contract, leaving a small memory pool providing long lasting immunity. While it has been described that…”
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A dominant role for the immunoproteasome in CD8+ T cell responses to murine cytomegalovirus by Hutchinson, Sarah, Sims, Stuart, O'Hara, Geraldine, Silk, Jon, Gileadi, Uzi, Cerundolo, Vincenzo, Klenerman, Paul

“…Murine cytomegalovirus (MCMV) is an important animal model of human cytomegalovirus (HCMV), a β-Herpesvirus that infects the majority of the world's population…”
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In Vitro Comparison of the Internal Ribosomal Entry Site Activity from Rodent Hepacivirus and Pegivirus and Construction of Pseudoparticles by Sims, Stuart, Michaelsen, Kevin, Burkhard, Sara, Fraefel, Cornel

“…The 5′ untranslated region (5′ UTR) of rodent hepacivirus (RHV) and pegivirus (RPgV) contains sequence homology to the HCV type III internal ribosome entry…”
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CD73 is dispensable for the regulation of inflationary CD8+ T-cells after murine cytomegalovirus infection and adenovirus immunisation by Sims, Stuart, Colston, Julia, Bolinger, Beatrice, Emery, Vince, Klenerman, Paul

“…The ecto-5'-nucleotidase (CD73) is expressed by T-cell subsets, myeloid derived suppressive cells and endothelial cells. It works in conjunction with CD39 to…”
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Adenoviral Vector Vaccination Induces a Conserved Program of CD8+ T Cell Memory Differentiation in Mouse and Man by Bolinger, Beatrice, Sims, Stuart, Swadling, Leo, O’Hara, Geraldine, de Lara, Catherine, Baban, Dilair, Saghal, Natasha, Lee, Lian Ni, Marchi, Emanuele, Davis, Mark, Newell, Evan, Capone, Stefania, Folgori, Antonella, Barnes, Ellie, Klenerman, Paul

“…Following exposure to vaccines, antigen-specific CD8+ T cell responses develop as long-term memory pools. Vaccine strategies based on adenoviral vectors, e.g.,…”
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Efficacious Early Antiviral Activity of HIV Gag- and Pol-Specific HLA-B2705-Restricted CD8+ T Cells by PAYNE, Rebecca P, KLØVERPRIS, Henrik, LUZZI, Graz, EDWARDS, Anne, PHILLIPS, Rodney, PRADO, Julia G, GOULDER, Philip J. R, SACHA, Jonah B, BRUMME, Zabrina, BRUMME, Chanson, BUUS, Søren, SIMS, Stuart, HICKLING, Stephen, RIDDELL, Lynn, FABIAN CHEN

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Saporin-conjugated tetramers identify efficacious anti-HIV CD8+ T-cell specificities by Leitman, Ellen M, Palmer, Christine D, Buus, Søren, Chen, Fabian, Riddell, Lynn, Sims, Stuart, Klenerman, Paul, Sáez-Cirión, Asier, Walker, Bruce D, Hess, Paul R, Altfeld, Marcus, Matthews, Philippa C, Goulder, Philip J R

“…Antigen-specific T-cells are highly variable, spanning potent antiviral efficacy and damaging auto-reactivity. In virus infections, identifying the most…”
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Transient CD8-memory contraction: a potential contributor to latent cytomegalovirus reactivation by Campbell, Jonathan, Trgovcich, Joanne, Kincaid, Michelle, Zimmerman, Peter D., Klenerman, Paul, Sims, Stuart, Cook, Charles H.

“…Heterologous antigen encounters can induce transient T‐memory contraction, allowing cytomegaloviral recrudescence in latently infected immunocompetent hosts…”
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HLArestrictor—a tool for patient-specific predictions of HLA restriction elements and optimal epitopes within peptides by Erup Larsen, Malene, Kloverpris, Henrik, Stryhn, Anette, Koofhethile, Catherine K., Sims, Stuart, Ndung’u, Thumbi, Goulder, Philip, Buus, Søren, Nielsen, Morten

“…Traditionally, T cell epitope discovery requires considerable amounts of tedious, slow, and costly experimental work. During the last decade, prediction tools…”
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A genetic and functional relationship between T cells and cellular proliferation in the adult hippocampus by Huang, Guo-Jen, Smith, Adrian L, Gray, Daniel H D, Cosgrove, Cormac, Singer, Benjamin H, Edwards, Andrew, Sims, Stuart, Sim, Stuart, Parent, Jack M, Johnsen, Alyssa, Mott, Richard, Mathis, Diane, Klenerman, Paul, Benoist, Christophe, Flint, Jonathan

“…Neurogenesis continues through the adult life of mice in the subgranular zone of the dentate gyrus in the hippocampus, but its function remains unclear…”
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Humanising pedagogic research in higher education: A reflective commentary on a university-wide special interest group by Koseoglu, Suzan, Voskou, Angeliki, Sims, Stuart

“…In this article, we reflect on our efforts supporting an institution-wide special interest group (SIG) on pedagogic research. Initiated by the Academic and…”
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Identifying opportunities and gaps in current evaluation frameworks - the knowns and unknowns in determining effective student engagement activity by Wilson, Caroline, Sims, Stuart, Dyer, Jen, Handley, Fiona

“…The higher education sector is under increasing pressure to deliver more and to evidence the fruits of its contribution to society. There is a particular focus…”
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Increasing inflationary T‐cell responses following transient depletion of MCMV‐specific memory T cells by Sims, Stuart, Klenerman, Paul

“…Murine CMV (MCMV) infection induces effector CD8+ T cells that continue to increase in frequency after acute infection (“inflation”) and are stably maintained…”
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Challenges, barriers and strategies for engaging in level 7 apprenticeship studies by Poole, Richard, Cook, Fiona, Sims, Stuart, Brindley, Joanne

“…This study explores the lived experience of apprentices on a degree-level programme and their perceptions of how elements of apprenticeship study that aren't…”
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Level 7 degree apprenticeships - a story of challenge, resilience and success by Cook, Fiona, Sims, Stuart, Brindley, Joanne, Poole, Richard

“…This study explores the lived experience of both in-service and pre-service apprentices studying Level 7 apprenticeship programmes. Using qualitative…”
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Multiple transmission routes sustain high prevalence of a virulent parasite in a butterfly host by Majewska, Ania A, Sims, Stuart, Schneider, Anna, Altizer, Sonia, Hall, Richard J

“…Understanding factors that allow highly virulent parasites to reach high infection prevalence in host populations is important for managing infection risks to…”
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Multiple transmission routes sustain high prevalence of a virulent parasite in a butterfly host by Majewska, Ania A., Sims, Stuart, Schneider, Anna, Altizer, Sonia, Hall, Richard J.

“…Understanding factors that allow highly virulent parasites to reach high infection prevalence in host populations is important for managing infection risks to…”
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Real‐life research projects improve student engagement and provide reliable data for academics by Marley, Sarah A., Siani, Alessandro, Sims, Stuart

“…Student engagement can have a positive influence on student success. Many methods exist for fostering engagement but tend to be generic and require tailoring…”
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MHC-peptide tetramers for the analysis of antigen-specific T cells by Sims, Stuart, Willberg, Christian, Klenerman, Paul

“…The development of the fluorescently labeled tetrameric MHC-peptide complex has enabled the direct visualization, quantification and phenotypic…”
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Healing while parasitized: impact of a naturally‐occurring nematode during energy‐intensive wound‐healing in a beetle by Davis, Andrew K., Calderon, Lexi, Lefeuvre, Jake, Sims, Stuart, Pearce, Jana, Prouty, Cody

“…The rigours of the daily lives of insects sometimes lead to minor injuries and wounds, which must be healed to avoid entry of pathogens and to resume normal…”
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