Search Results - "Sims, Neil R."

Reactive astrogliosis in stroke: Contributions of astrocytes to recovery of neurological function by Sims, Neil R., Yew, Wai Ping

“…Alterations in neuronal connectivity, particularly in the “peri-infarct” tissue adjacent to the region of ischemic damage, are important contributors to the…”
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Mitochondria, oxidative metabolism and cell death in stroke by Sims, Neil R., Muyderman, Hakan

“…Stroke most commonly results from occlusion of a major artery in the brain and typically leads to the death of all cells within the affected tissue…”
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Isolation of mitochondria from rat brain using Percoll density gradient centrifugation by Sims, Neil R, Anderson, Michelle F

“…We have developed procedures that combine differential centrifugation and discontinuous Percoll density gradient centrifugation to isolate mitochondria from…”
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Early treatment with minocycline following stroke in rats improves functional recovery and differentially modifies responses of peri-infarct microglia and astrocytes by Yew, Wai Ping, Djukic, Natalia D, Jayaseelan, Jaya S P, Walker, Frederick R, Roos, Karl A A, Chataway, Timothy K, Muyderman, Hakan, Sims, Neil R

“…Altered neuronal connectivity in peri-infarct tissue is an important contributor to both the spontaneous recovery of neurological function that commonly…”
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Investigation of Mature BDNF and proBDNF Signaling in a Rat Photothrombotic Ischemic Model by Rahman, Mehreen, Luo, Haiyun, Sims, Neil R., Bobrovskaya, Larisa, Zhou, Xin-Fu

“…Treatment with mature brain-derived neurotrophic factor (mBDNF) promotes functional recovery after ischemia in animal trials but the possible role of its…”
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Differential effects of the cell cycle inhibitor, olomoucine, on functional recovery and on responses of peri-infarct microglia and astrocytes following photothrombotic stroke in rats by Yew, Wai Ping, Djukic, Natalia D, Jayaseelan, Jaya S P, Woodman, Richard J, Muyderman, Hakan, Sims, Neil R

“…Following stroke, changes in neuronal connectivity in tissue surrounding the infarct play an important role in both spontaneous recovery of neurological…”
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Delayed Treatment with Human Dental Pulp Stem Cells Accelerates Functional Recovery and Modifies Responses of Peri-Infarct Astrocytes Following Photothrombotic Stroke in Rats by Yew, Wai Ping, Djukic, Natalia D., Jayaseelan, Jaya S. P., Kaidonis, Xenia, Kremer, Karlea L., Choy, Fong Chan, Woodman, Richard J., Koblar, Simon A., Sims, Neil R.

“…Dental pulp contains multipotent mesenchymal stem cells that improve outcomes when administered early after temporary middle cerebral artery occlusion in rats…”
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Highly Selective and Prolonged Depletion of Mitochondrial Glutathione in Astrocytes Markedly Increases Sensitivity to Peroxynitrite by Muyderman, Hakan, Nilsson, Michael, Sims, Neil R

“…Glutathione, a major endogenous antioxidant, is found in two intracellular pools in the cytoplasm and the mitochondria. To investigate the importance of the…”
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The mitochondrial T1095C mutation increases gentamicin-mediated apoptosis by Muyderman, Hakan, Sims, Neil R, Tanaka, Masashi, Fuku, Noriyuki, Raghupathi, Ravinarayan, Thyagarajan, Dominic

“…We have previously reported a heteroplasmic mtDNA mutation (T1095C) in the 12SrRNA gene of an Italian family with features of maternally-inherited…”
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Mitochondrial glutathione protects against cell death induced by oxidative and nitrative stress in astrocytes by Muyderman, Håkan, Wadey, Alison L, Nilsson, Michael, Sims, Neil R

“…The major cellular antioxidant, glutathione, is mostly localized in the cytosol but a small portion is found in mitochondria. We have recently shown that…”
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The effects of focal ischemia and reperfusion on the glutathione content of mitochondria from rat brain subregions by Anderson, Michelle F., Sims, Neil R.

“…Glutathione is a key cellular antioxidant that is contained in both cytoplasmic and mitochondrial compartments. Previous investigations indicate that depletion…”
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Glutathione monoethyl ester provides neuroprotection in a rat model of stroke by Anderson, Michelle F, Nilsson, Michael, Eriksson, Peter S, Sims, Neil R

“…Oxidative stress plays an important role in the development of tissue damage following transient focal cerebral ischaemia. Glutathione is a central component…”
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Fluorocitrate-mediated astroglial dysfunction causes seizures by Willoughby, John O., Mackenzie, Lorraine, Broberg, Marita, Thoren, Anna E., Medvedev, Andrei, Sims, Neil R., Nilsson, Michael

“…A role for astroglia in epileptogenesis has been hypothesised but is not established. Low doses of fluorocitrate specifically and reversibly disrupt astroglial…”
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(−)-Epigallocatechin gallate as an intervention for the acute treatment of cerebral ischemia by Rahman, Rosanna M.A., Nair, Shiva M., Helps, Stephen C., Shaw, Odette M., Sims, Neil R., Rosengren, Rhonda J., Appleton, Ian

“…This study examined the neuroprotective effects and possible hepatotoxicity of (−)-epigallocatechin gallate (EGCG) in a rat model of transient focal cerebral…”
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Mitochondrial contributions to tissue damage in stroke by Sims, Neil R., Anderson, Michelle F.

“…Tissue infarction, involving death of essentially all cells within a part of the brain, is a common pathology resulting from stroke and an important…”
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Mitochondrial glutathione uptake: characterization in isolated brain mitochondria and astrocytes in culture by Wadey, Alison L, Muyderman, Hakan, Kwek, Perrin T, Sims, Neil R

“…Glutathione in the mitochondria is an important determinant of cellular responses to oxidative stress. Mitochondrial glutathione is maintained by uptake from…”
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Isolation of brain mitochondria from neonatal mice by Wang, Xiaoyang, Leverin, Anna‐Lena, Han, Wei, Zhu, Changlian, Johansson, Bengt R., Jacotot, Etienne, Ten, Vadim S., Sims, Neil R., Hagberg, Henrik

“…J. Neurochem. (2011) 10.1111/j.1471‐4159.2011.07525.x Mitochondria are key contributors to many forms of cell death including those resulting from neonatal…”
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David Bowen, 1940–2011 by Palmer, Alan M., Sims, Neil R., Francis, Paul T.

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The metabolism of C-glucose by neurons and astrocytes in brain subregions following focal cerebral ischemia in rats by Thoren, Anna E, Helps, Stephen C, Nilsson, Michael, Sims, Neil R

“…To provide insights into the effects of temporary focal ischemia on the function of neurons and astrocytes in vivo, we measured the incorporation of radiolabel…”
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Alterations in Membrane Potential in Mitochondria Isolated from Brain Subregions During Focal Cerebral Ischemia and Early Reperfusion: Evaluation Using Flow Cytometry by Lee, Diane R., Helps, Stephen C., Macardle, Peter J., Nilsson, Michael, Sims, Neil R.

“…Mitochondria isolated from brain tissue following middle cerebral artery occlusion or during early reperfusion were tested for their ability to generate a…”
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