CJ-15,696 and its analogs, new furopyridine antibiotics from the fungus Cladobotryum varium: fermentation, isolation, structural elucidation, biotransformation and antibacterial activities

CJ-15,696 and 7 novel furopyridine antibiotics were isolated from the fungus Cladobotryum varium CL12284. Their structures were determined by X-ray crystallography and spectral analysis. Three biotransformed analogs were also prepared from CJ-15,696. CJ-15,696 showed moderate activity against variou...

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Bibliographic Details

Published in:	Journal of antibiotics Vol. 55; no. 1; p. 6
Main Authors:	Sakemi, Shinichi, Bordner, Jon, DeCosta, Debra L, Dekker, Koen A, Hirai, Hideo, Inagaki, Taisuke, Kim, Yoon-Jeong, Kojima, Nakao, Sims, Jeffrey C, Sugie, Yutaka, Sugiura, Akemi, Sutcliffe, Joyce A, Tachikawa, Kiyoshi, Truesdell, Susan J, Wong, John W, Yoshikawa, Nobuji, Kojima, Yasuhiro
Format:	Journal Article
Language:	English
Published:	Japan 01-01-2002
Subjects:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Biotransformation Fermentation Gram-Positive Bacteria Microbial Sensitivity Tests Structure-Activity Relationship
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