Search Results - "Simpson, Sydney"

Fewer peripheral intravenous catheter complications in hospitalized dogs when force-activated separation devices are used versus not used in a randomized controlled clinical trial by Simpson, Sydney E., Zersen, Kristin M.

“…Abstract OBJECTIVE To determine whether the use of a force-activated separation device (FASD) lowers the incidence risk of peripheral intravenous catheter…”
Get full text

Mutations accumulated in the Spike of SARS-CoV-2 Omicron allow for more efficient counteraction of the restriction factor BST2/Tetherin by Shi, Yuhang, Simpson, Sydney, Chen, Yuexuan, Aull, Haley, Benjamin, Jared, Serra-Moreno, Ruth

“…BST2/Tetherin is a restriction factor with broad antiviral activity against enveloped viruses, including coronaviruses. Specifically, BST2 traps nascent…”
Get full text

Data-Driven Techniques for Low-Cost Sensor Selection and Calibration for the Use Case of Air Quality Monitoring by Kureshi, Rameez Raja, Mishra, Bhupesh Kumar, Thakker, Dhavalkumar, John, Reena, Walker, Adrian, Simpson, Sydney, Thakkar, Neel, Wante, Agot Kirsten

“…With the emergence of Low-Cost Sensor (LCS) devices, measuring real-time data on a large scale has become a feasible alternative approach to more costly…”
Get full text

Monocytes complexed to platelets differentiate into functionally deficient dendritic cells by Singh, Meera V., Suwunnakorn, Sumanun, Simpson, Sydney R., Weber, Emily A., Singh, Vir B., Kalinski, Pawel, Maggirwar, Sanjay B.

“…In addition to their role in hemostasis, platelets store numerous immunoregulatory molecules such as CD40L, TGFβ, β2‐microglobulin, and IL‐1β and release them…”
Get full text

HIV Nef-mediated Ubiquitination of BCL2: Implications in Autophagy and Apoptosis by Castro-Gonzalez, Sergio, Simpson, Sydney, Shi, Yuhang, Chen, Yuexuan, Benjamin, Jared, Serra-Moreno, Ruth

“…Ubiquitination is a process that acts upon every step of the HIV replication cycle. The activity, subcellular localization, and stability of HIV dependency…”
Get full text

The Antiviral Factor SERINC5 Impairs the Expression of Non-Self-DNA by Shi, Yuhang, Simpson, Sydney, Ahmed, Shahad K, Chen, Yuexuan, Tavakoli-Tameh, Aidin, Janaka, Sanath Kumar, Evans, David T, Serra-Moreno, Ruth

“…SERINC5 is a restriction factor that becomes incorporated into nascent retroviral particles, impairing their ability to infect target cells. In turn,…”
Get full text

Platelets function as an acute viral reservoir during HIV-1 infection by harboring virus and T-cell complex formation by Simpson, Sydney R., Singh, Meera V., Dewhurst, Stephen, Schifitto, Giovanni, Maggirwar, Sanjay B.

“…Platelets were recently found to harbor infectious HIV virions in infected individuals who are on antiretroviral treatment with poor CD4+ T-cell recovery. In…”
Get full text

Curaxin CBL0100 Blocks HIV-1 Replication and Reactivation through Inhibition of Viral Transcriptional Elongation by Jean, Maxime J, Hayashi, Tsuyoshi, Huang, Huachao, Brennan, Justin, Simpson, Sydney, Purmal, Andrei, Gurova, Katerina, Keefer, Michael C, Kobie, James J, Santoso, Netty G, Zhu, Jian

“…Despite combination antiretroviral therapy (cART), acquired immunodeficiency syndrome (AIDS), predominantly caused by the human immunodeficiency virus type 1…”
Get full text

Using Citizen Science to Complement IoT Data Collection: A Survey of Motivational and Engagement Factors in Technology-Centric Citizen Science Projects by Ali, Muhammad Uzar, Mishra, Bhupesh Kumar, Thakker, Dhavalkumar, Mazumdar, Suvodeep, Simpson, Sydney

“…A key aspect of the development of Smart Cities involves the efficient and effective management of resources to improve liveability. Achieving this requires…”
Get full text

A Novel Bromodomain Inhibitor Reverses HIV-1 Latency through Specific Binding with BRD4 to Promote Tat and P-TEFb Association by Huang, Huachao, Liu, Shuai, Jean, Maxime, Simpson, Sydney, Huang, He, Merkley, Mark, Hayashi, Tsuyoshi, Kong, Weili, Rodríguez-Sánchez, Irene, Zhang, Xiaofeng, Yosief, Hailemichael O, Miao, Hongyu, Que, Jianwen, Kobie, James J, Bradner, James, Santoso, Netty G, Zhang, Wei, Zhu, Jian

“…While combinatory antiretroviral therapy (cART) can effectively reduce HIV-1 viremia, it cannot eliminate HIV-1 infection. In the presence of cART, viral…”
Get full text

Inhibition of Tip60 Reduces Lytic and Latent Gene Expression of Kaposi's Sarcoma-Associated Herpes Virus (KSHV) and Proliferation of KSHV-Infected Tumor Cells by Simpson, Sydney, Fiches, Guillaume, Jean, Maxime J, Dieringer, Michael, McGuinness, James, John, Sinu P, Shamay, Meir, Desai, Prashant, Zhu, Jian, Santoso, Netty G

“…Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic virus responsible for the development of Kaposi's sarcoma, primary effusion lymphoma (PEL), and…”
Get full text

Synthesis and Characterization of Cobalt(II) N,N′‑Diphenylazodioxide Complexes by Emhoff, Kylin A, Balaraman, Lakshmi, Simpson, Sydney R, Stromyer, Michael L, Kalil, Haitham F, Beemiller, James R, Sikatzki, Philipp, Eshelman, Teya S, Salem, Ahmed M. H, DeBord, Michael A, Panzner, Matthew J, Youngs, Wiley J, Boyd, W. Christopher

“…Removal of chloride from CoCl2 with TlPF6 in acetonitrile, followed by addition of excess nitrosobenzene, yielded the eight-coordinate cobalt­(II) complex salt…”
Get full text

Studying platelet-HIV interactions and potential to promote viral spread by Simpson, Sydney, Singh, Meera V., Dewhurst, Stephen, Maggirwar, Sanjay

“…Abstract HIV-infected individuals experience persistent inflammation, which is associated with increased platelet activation. There is growing evidence that…”
Get full text

Explainable Artificial Intelligence for Developing Smart Cities Solutions by Thakker, Dhavalkumar, Mishra, Bhupesh Kumar, Abdullatif, Amr, Mazumdar, Suvodeep, Simpson, Sydney

“…Traditional Artificial Intelligence (AI) technologies used in developing smart cities solutions, Machine Learning (ML) and recently Deep Learning (DL), rely…”
Get full text

Screening of an FDA-approved compound library identifies levosimendan as a novel anti-HIV-1 agent that inhibits viral transcription by Hayashi, Tsuyoshi, Jean, Maxime, Huang, Huachao, Simpson, Sydney, Santoso, Netty G., Zhu, Jian

“…Combination antiretroviral therapy (cART) has been proven to efficiently inhibit ongoing replication of human immunodeficiency virus type 1 (HIV-1), and…”
Get full text

IFI44 suppresses HIV-1 LTR promoter activity and facilitates its latency by Power, Derek, Santoso, Netty, Dieringer, Michael, Yu, Jack, Huang, Huachao, Simpson, Sydney, Seth, Ishir, Miao, Hongyu, Zhu, Jian

“…Abstract IFI44 is an interferon-alfa inducible protein, and is associated with infection of several viruses. However, IFI44 elicits minimal antiviral effects…”
Get full text

FACT Proteins, SUPT16H and SSRP1, Are Transcriptional Suppressors of HIV-1 and HTLV-1 That Facilitate Viral Latency by Huang, Huachao, Santoso, Netty, Power, Derek, Simpson, Sydney, Dieringer, Michael, Miao, Hongyu, Gurova, Katerina, Giam, Chou-Zen, Elledge, Stephen J., Zhu, Jian

“…Our functional genomic RNAi screens have identified the protein components of the FACT (facilitates chromatin transcription) complex, SUPT16H and SSRP1, as top…”
Get full text

Pharmacokinetics and anti‐nausea effects of intravenous ondansetron in hospitalized dogs exhibiting clinical signs of nausea by Sotelo, Cindy K., Shropshire, Sarah B., Quimby, Jessica, Simpson, Sydney, Gustafson, Daniel L., Zersen, Kristin M.

“…The purpose of this study was to evaluate the pharmacokinetics of intravenous (IV) ondansetron in a population of hospitalized dogs exhibiting clinical signs…”
Get full text

A novel application of deep learning with image cropping: a smart city use case for flood monitoring by Mishra, Bhupesh Kumar, Thakker, Dhavalkumar, Mazumdar, Suvodeep, Neagu, Daniel, Gheorghe, Marian, Simpson, Sydney

“…Event monitoring is an essential application of Smart City platforms. Real-time monitoring of gully and drainage blockage is an important part of flood…”
Get full text

Characterization of Two Disparate Modes by Which Viruses Exploit Host-Factors to Promote Their Own Dissemination and Replication by Simpson, Sydney R

“…Viruses are intracellular parasites that rely on host-derived factors to survive. In this thesis, I describe two disparate modes by which pathogenic human…”
Get full text