Search Results - "Simpson, Peter T"

Invasive lobular carcinoma of the breast: the increasing importance of this special subtype by McCart Reed, Amy E, Kalinowski, Lauren, Simpson, Peter T, Lakhani, Sunil R

“…Invasive lobular carcinoma (ILC) is the most common of the breast cancer special types, accounting for up to 15% of all breast cancer cases. ILCs are noted for…”
Get full text

Invasive lobular carcinoma of the breast: morphology, biomarkers and 'omics by McCart Reed, Amy E, Kutasovic, Jamie R, Lakhani, Sunil R, Simpson, Peter T

“…Invasive lobular carcinoma of the breast is the most common 'special' morphological subtype of breast cancer, comprising up to 15% of all cases. Tumours are…”
Get full text

Metastatic progression of breast cancer: insights from 50 years of autopsies by Cummings, Margaret C, Simpson, Peter T, Reid, Lynne E, Jayanthan, Janani, Skerman, Joanna, Song, Sarah, McCart Reed, Amy E, Kutasovic, Jamie R, Morey, Adrienne L, Marquart, Louise, O'Rourke, Peter, Lakhani, Sunil R

“…There remain no clear guidelines for the optimal management of patients with metastatic breast cancer. To better understand its natural history, we undertook a…”
Get full text

miR-139-5p is a regulator of metastatic pathways in breast cancer by Krishnan, Keerthana, Steptoe, Anita L, Martin, Hilary C, Pattabiraman, Diwakar R, Nones, Katia, Waddell, Nic, Mariasegaram, Mythily, Simpson, Peter T, Lakhani, Sunil R, Vlassov, Alexander, Grimmond, Sean M, Cloonan, Nicole

“…Metastasis is a complex, multistep process involved in the progression of cancer from a localized primary tissue to distant sites, often characteristic of the…”
Get full text

Metaplastic breast cancers frequently express immune checkpoint markers FOXP3 and PD-L1 by Kalaw, Emarene, Lim, Malcolm, Kutasovic, Jamie R., Sokolova, Anna, Taege, Lucinda, Johnstone, Kate, Bennett, James, Saunus, Jodi M., Niland, Colleen, Ferguson, Kaltin, Gresshoff, Irma, Bettington, Mark, Pathmanathan, Nirmala, Tse, Gary M., Papadimos, David, Pathmanathan, Rajadurai, Harris, Gavin, Yamaguchi, Rin, Tan, Puay Hoon, Fox, Stephen, O’Toole, Sandra A., Simpson, Peter T., Lakhani, Sunil R., McCart Reed, Amy E.

“…Background Metaplastic breast carcinoma encompasses a heterogeneous group of tumours with differentiation into squamous and/or spindle, chondroid, osseous or…”
Get full text

Expression of MAGE‐A and NY‐ESO‐1 cancer/testis antigens is enriched in triple‐negative invasive breast cancers by Raghavendra, Ashwini, Kalita‐de Croft, Priyakshi, Vargas, Ana C, Smart, Chanel E, Simpson, Peter T, Saunus, Jodi M, Lakhani, Sunil R

“…Aims A better understanding of the expression of cancer/testis antigens (CTAs) in breast cancer might enable the identification of new immunotherapy options,…”
Get full text

Whole genome deep sequencing analysis of cell-free DNA in samples with low tumour content by Ganesamoorthy, Devika, Robertson, Alan James, Chen, Wenhan, Hall, Michael B, Cao, Minh Duc, Ferguson, Kaltin, Lakhani, Sunil R, Nones, Katia, Simpson, Peter T, Coin, Lachlan J M

“…Circulating cell-free DNA (cfDNA) in the plasma of cancer patients contains cell-free tumour DNA (ctDNA) derived from tumour cells and it has been widely…”
Get full text

B7-H3 Expression in Breast Cancer and Brain Metastasis by Joshi, Vaibhavi, Beecher, Kate, Lim, Malcolm, Stacey, Andrew, Feng, Yufan, Jat, Parmjit S, Duijf, Pascal H G, Simpson, Peter T, Lakhani, Sunil R, McCart Reed, Amy E

“…Brain metastasis is a significant challenge for some breast cancer patients, marked by its aggressive nature, limited treatment options, and poor clinical…”
Get full text

Integrin alpha-2 and beta-1 expression increases through multiple generations of the EDW01 patient-derived xenograft model of breast cancer-insight into their role in epithelial mesenchymal transition in vivo gained from an in vitro model system by Wafai, Razan, Williams, Elizabeth D, de Souza, Emma, Simpson, Peter T, McCart Reed, Amy E, Kutasovic, Jamie R, Waltham, Mark, Snell, Cameron E, Blick, Tony, Thompson, Erik W, Hugo, Honor J

“…Breast cancers acquire aggressive capabilities via epithelial to mesenchymal transition (EMT), in which various integrins/integrin-linked kinase signalling are…”
Get full text

MicroRNA-182-5p targets a network of genes involved in DNA repair by Krishnan, Keerthana, Steptoe, Anita L, Martin, Hilary C, Wani, Shivangi, Nones, Katia, Waddell, Nic, Mariasegaram, Mythily, Simpson, Peter T, Lakhani, Sunil R, Gabrielli, Brian, Vlassov, Alexander, Cloonan, Nicole, Grimmond, Sean M

“…MicroRNAs are noncoding regulators of gene expression, which act by repressing protein translation and/or degrading mRNA. Many have been shown to drive…”
Get full text

Performance of somatic structural variant calling in lung cancer using Oxford Nanopore sequencing technology by Liu, Lingchen, Zhang, Jia, Wood, Scott, Newell, Felicity, Leonard, Conrad, Koufariotis, Lambros T, Nones, Katia, Dalley, Andrew J, Chittoory, Haarika, Bashirzadeh, Farzad, Son, Jung Hwa, Steinfort, Daniel, Williamson, Jonathan P, Bint, Michael, Pahoff, Carl, Nguyen, Phan T, Twaddell, Scott, Arnold, David, Grainge, Christopher, Simpson, Peter T, Fielding, David, Waddell, Nicola, Pearson, John V

“…Lung cancer is a heterogeneous disease and the primary cause of cancer-related mortality worldwide. Somatic mutations, including large structural variants, are…”
Get full text

Calcium channel TRPV6 as a potential therapeutic target in estrogen receptor-negative breast cancer by Peters, Amelia A, Simpson, Peter T, Bassett, Johnathon J, Lee, Jane M, Da Silva, Leonard, Reid, Lynne E, Song, Sarah, Parat, Marie-Odile, Lakhani, Sunil R, Kenny, Paraic A, Roberts-Thomson, Sarah J, Monteith, Gregory R

“…Calcium signaling is a critical regulator of cell proliferation. Elevated expression of calcium channels and pumps is a characteristic of some cancers,…”
Get full text

Runx2 is a novel regulator of mammary epithelial cell fate in development and breast cancer by Owens, Thomas W, Rogers, Renee L, Best, Sarah, Ledger, Anita, Mooney, Anne-Marie, Ferguson, Alison, Shore, Paul, Swarbrick, Alexander, Ormandy, Christopher J, Simpson, Peter T, Carroll, Jason S, Visvader, Jane, Naylor, Matthew J

“…Regulators of differentiated cell fate can offer targets for managing cancer development and progression. Here, we identify Runx2 as a new regulator of…”
Get full text

Aberrant Expression of E-cadherin in Lobular Carcinomas of the Breast by DA SILVA, Leonard, PARRY, Suzanne, REID, Lynne, KEITH, Patricia, WADDELL, Nic, KOSSAI, Myriam, CLARKE, Catherine, LAKHANI, Sunil R, SIMPSON, Peter T

“…Invasive lobular carcinoma (ILC) and lobular carcinoma in situ characteristically show loss of E-cadherin expression and so immunohistochemistry for E-cadherin…”
Get full text

Next-Generation Sequencing of Endobronchial Ultrasound Transbronchial Needle Aspiration Specimens in Lung Cancer by Fielding, David, Dalley, Andrew J, Bashirzadeh, Farzad, Singh, Mahendra, Nandakumar, Lakshmy, McCart Reed, Amy E, Black, Debra, Kazakoff, Stephen, Nones, Katia, Pearson, John, Waddell, Nic, Lakhani, Sunil R, Simpson, Peter T

“…Malignancy was confirmed in 66 cases (42 adenocarcinoma, 11 small cell lung cancer, 10 squamous cell carcinoma, and 3 metastatic malignancy: renal cell…”
Get full text

Proteogenomic analysis of Inhibitor of Differentiation 4 (ID4) in basal-like breast cancer by Baker, Laura A, Holliday, Holly, Roden, Daniel, Krisp, Christoph, Wu, Sunny Z, Junankar, Simon, Serandour, Aurelien A, Mohammed, Hisham, Nair, Radhika, Sankaranarayanan, Geetha, Law, Andrew M K, McFarland, Andrea, Simpson, Peter T, Lakhani, Sunil, Dodson, Eoin, Selinger, Christina, Anderson, Lyndal, Samimi, Goli, Hacker, Neville F, Lim, Elgene, Ormandy, Christopher J, Naylor, Matthew J, Simpson, Kaylene, Nikolic, Iva, O'Toole, Sandra, Kaplan, Warren, Cowley, Mark J, Carroll, Jason S, Molloy, Mark, Swarbrick, Alexander

“…Basal-like breast cancer (BLBC) is a poorly characterised, heterogeneous disease. Patients are diagnosed with aggressive, high-grade tumours and often relapse…”
Get full text

Novel highly specific anti‐periostin antibodies uncover the functional importance of the fascilin 1‐1 domain and highlight preferential expression of periostin in aggressive breast cancer by Field, Sarah, Uyttenhove, Catherine, Stroobant, Vincent, Cheou, Paméla, Donckers, Dominique, Coutelier, Jean‐Paul, Simpson, Peter T., Cummings, Margaret C., Saunus, Jodi M., Reid, Lynne E., Kutasovic, Jamie R., McNicol, Anne Marie, Kim, Ba Reun, Kim, Jae Ho, Lakhani, Sunil R., Neville, A. Munro, Van Snick, Jacques, Jat, Parmjit S.

“…Periostin (POSTN), a secreted homodimeric protein that binds integrins αvβ3, αvβ5, and α6β4, was originally found to be expressed in fetal tissues and in the…”
Get full text

In vitro analysis of breast cancer cell line tumourspheres and primary human breast epithelia mammospheres demonstrates inter- and intrasphere heterogeneity by Smart, Chanel E, Morrison, Brian J, Saunus, Jodi M, Vargas, Ana Cristina, Keith, Patricia, Reid, Lynne, Wockner, Leesa, Askarian-Amiri, Marjan, Amiri, Marjan Askarian, Sarkar, Debina, Simpson, Peter T, Clarke, Catherine, Schmidt, Chris W, Reynolds, Brent A, Lakhani, Sunil R, Lopez, J Alejandro

“…Mammosphere and breast tumoursphere culture have gained popularity as in vitro assays for propagating and analysing normal and cancer stem cells. Whether the…”
Get full text

Discrepancies in tumor mutation burden reporting from sequential endobronchial ultrasound transbronchial needle aspiration samples within single lymph node stations - brief report by Fielding, David, Dalley, Andrew J., Singh, Mahendra, Nandakumar, Lakshmy, Lakis, Vanessa, Chittoory, Haarika, Fairbairn, David, Patch, Ann-Marie, Kazakoff, Stephen H., Ferguson, Kaltin, Bashirzadeh, Farzad, Bint, Michael, Pahoff, Carl, Son, Jung Hwa, Ryan, Kimberley, Hodgson, Alan, Sharma, Sowmya, Pearson, John V., Waddell, Nicola, Lakhani, Sunil R., Hartel, Gunter, Simpson, Peter T., Nones, Katia

“…Introduction Tumour Mutation Burden (TMB) is a potential biomarker for immune cancer therapies. Here we investigated parameters that might affect TMB using…”
Get full text

Thrombospondin-4 expression is activated during the stromal response to invasive breast cancer by McCart Reed, Amy E., Song, Sarah, Kutasovic, Jamie R., Reid, Lynne E., Valle, Jordan M., Vargas, Ana Cristina, Smart, Chanel E., Simpson, Peter T.

“…The thromobospondins are a family of extracellular glycoproteins that are activated during tissue remodeling processes such as embryogenesis, wound healing and…”
Get full text